Artigos científicos, teses e dissertações
Publicados nas melhores instituições de ensino

Mechanisms of lymphocytotoxicity induced by extracorporeal photochemotherapy for cutaneous T cell lymphoma.

Extracorporeal photochemotherapy is an effective treatment for cutaneous T cell lymphoma but its mode of action is uncertain. The reduction in viability of patients' photoirradiated buffy coat lymphocytes was correlated with a 35% increase in DNA single-strand breaks and marked d...

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Blocking or enhancing effects of some basic emollients in UVA penetration

Abstract: Background: Topical agents used in combination with phototherapy or photochemotherapy may have both blocking or enhancing effects in ultraviolet rays. Objective: In this in vivo study, the effects of topical petrolatum, basis cream, glycerine, and olive oil on the tra...

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Photochemical Inactivation of Deoxyribonucleic and Ribonucleic Acid Viruses by Chlorpromazine

Chlorpromazine, a widely used tranquilizing drug of the phenothiazine group, was found to be a very potent photochemical inactivator of both deoxyribonucleic acid and ribonucleic acid viruses in the presence of long-wave ultraviolet light (320 to 380 nm). Neither the light alone ...

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Intramitochondrial dyes allow selective in vitro photolysis of carcinoma cells.

Carcinoma cell mitochondria preferentially accumulate and retain certain cationic dyes to a much greater extent than most normal cells. Thus, they can potentially serve as targets for highly selective photochemotherapy. We evaluated 10 rhodamine and cyanine dyes as carcinoma-spec...

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Targeted Antimicrobial Photochemotherapy

This study explores a new approach for antimicrobial therapy with light activation of targeted poly-l-lysine (pL)–chlorin e6 (ce6) conjugates. The goal was to test the hypothesis that these conjugates between pL and ce6 would efficiently target photodestruction towards gram-posit...

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Photocytotoxicity of a 5-nitrofuran-ethenyl-quinoline antiseptic (Quinifuryl) to P388 mouse leukemia cells

Quinifuryl (MW 449.52), 2-(5'-nitro-2'-furanyl)ethenyl-4-{N-[4'-(N,N-diethylamino)-1'-methylbutyl]carbamoyl} quinoline, is a water soluble representative of a family of 5-nitrofuran-ethenyl-quinoline drugs which has been shown to be highly toxic to various lines of transformed ce...

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Endodontic treatment of teeth with periapical lesion in one session with photodynamic therapy as an adjuvant: study "in vivo" / Tratamento endodôntico de dentes portadores de lesão periapical em sessão única tendo como coadjuvante a terapia fotodinâmica: estudo in vivo

Hipótese do estudo: O emprego da terapia fotodinâmica (PDT) como coadjuvante do tratamento endodôntico possa favorecer a reparação de dentes portadores de lesão periapical, tratados em sessão única. Objetivos: Este estudo in vivo, teve por objetivo avaliar, os efeitos da terapia ...

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Estudo das características espectroscópicas dos corantes ciânicos com dois cromóforos na interação com DNA: efeitos da força iônica. / Spectroscopic studies of bichromophoric cyanine dyes (BCD) in their interaction with DNA: effect of ionic strength.

Cancer is a pathology responsible for a great number of deaths. The conventional methods of treatment, chemotherapy and radiotherapy, are not always efficient, and multiple side effects are intrinsic for these therapies. In early 70’s appeared a new method called “Photodynamic Th...

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Estudo da pele do campo cancerizável antes e após a terapia fotodinâmica através dos métodos clínicos, histopatológicos e imunohistoquímicos / Clinical, histopathological and immunohistochemical assessment of human skin field cancerization before and after photodynamic therapy

O conceito de campo de cancerização, em dermatologia, sugere que a pele fotodanificada tem maior potencial para o desenvolvimento de neoplasias cutâneas. A terapia fotodinâmica (TFD) é um método não invasivo para o tratamento de queratoses actínicas (QA) múltiplas, possibilitando...

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Efeito da terapia antimicrobiana fotodinâmica no tratamento da periodontite experimental. Estudo bioquímico e microbiológico em cães / The effect of antimicrobial photodynamic therapy in the treatment of experimental periodontitis. A biochemical and microbiological study in dogs

The purpose of this study was to evaluate the effect of a single application of antimicrobial photodynamic therapy (aPDT) on microbiological profile and cytokine pattern in dogs. Periodontal disease was induced by placing 3.0 silk ligatures around the mandibular pre-molars bilate...

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