Phrenic Nerve Diaphragm
Mostrando 1-12 de 67 artigos, teses e dissertações.
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1. Presynaptic neuromuscular action of a methanolic extract from the venom of Rhinella schneideri toad
Background Rhinella schneideri, previously known as Bufo paracnemis, is a common toad in many regions of Brazil. Its venom exerts important cardiovascular effects on humans and other animals. Although this toad venom has been the subject of intense investigations, little is known about its neuromuscular activity. Methods The neurotoxicity of a methanolic
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 02/09/2014
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2. Diaphragmatic pacing stimulation in spinal cord injury: anesthetic and perioperative management
OBJECTIVE: The standard therapy for patients with high-level spinal cord injury is long-term mechanical ventilation through a tracheostomy. However, in some cases, this approach results in death or disability. The aim of this study is to highlight the anesthetics and perioperative aspects of patients undergoing insertion of a diaphragmatic pacemaker. METHODS
Clinics. Publicado em: 2012-11
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3. Augmentation of catecholamine release elicited by an Eugenia punicifolia extract in chromaffin cells
Plant extracts of Eugenia punicifolia (Kunth) DC., Myrtaceae, are used in Amazon region of Brazil to treat diarrhea and stomach disturbances, and as hypoglycemic medicine. We have recently shown that an aqueous extract of E. punicifolia augmented cholinergic neurotransmission in a rat phrenic nerve-diaphragm preparation. In this study, we investigated the ef
Revista Brasileira de Farmacognosia. Publicado em: 14/10/2011
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4. Heparin and commercial bothropic antivenom against the paralyzing effect of Bothrops jararacussu snake venom
The crude venom of Bothrops jararacussu (Bjssu) is known to induce muscular paralysis in vitro. Many studies have shown that various substances, including heparin, neutralize the damage caused by snake venom. In the present study, the ability of heparin (Hep) and commercial bothropic antivenom (CBA) to neutralize neuromuscular effects of Bjssu venom, at diff
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 26/02/2010
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5. Bothrops jararacussu venom-induced neuromuscular blockade inhibited by Casearia gossypiosperma Briquet hydroalcoholic extract
The hydroalcoholic extract of Casearia gossypiosperma Briquet (Flacourtiaceae) was standardized for the first time through quality control procedures including pharmacognostic methods, fingerprint chromatograms, defined amounts of marker substances and physicochemical characteristics. The pharmacological activity of C. gossypiosperma (Cg) hydroalcoholic extr
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2010
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6. CaracterizaÃÃo das atividades cardiorenal e neural de Bothrops marajoensis e suas fraÃÃes / CHARACTERIZATION OF TOTAL VENOM AND ITS FRACTION FROM THE Bothrops marajoensis IN CARDIORENAL AND NEURAL ACTIVITIES
Avaliou-se a atividade de Bothrops marajoensis (Bmj) e suas fraÃÃes no sistema cardiorrenal. A resposta pressora do veneno bruto demonstrou uma diminuiÃÃo da pressÃo arterial mÃdia e da freqÃÃncia cardÃaca, sem alteraÃÃes significativas na freqÃÃncia respiratÃria. Em ratos atropinizados demonstrou a permanÃncia dos efeitos. Na perfusÃo de cor
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/04/2009
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7. Efeitos dos anestesicos locais na transmissão neuromuscular e no bloqueio produzido pelo rocuronio : estudo experimental / The effects of local anesthetics on the neuromuscular transmission and on the blockade produced by rocuronium : experimental study
Local anesthetics can interact with neuromuscular blockers and modify their pharmacokinetics and pharmacodynamics properties but this mechanism of interaction is very controversial. This experimental study performed in rat phrenic nerve diaphragm preparation and chick biventer cervicis muscle, had the objective to evaluate the effect of different local anest
Publicado em: 2009
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8. Efeitos farmacologicos e morfologicos do polietilenoglicol (PEG 400) em preparações neuromusculares / The influence of polyethylene glycol 400 (PEG) on the neuromuscular junction
Polyethyleneglycol has been widely used in several areas such as cosmetic, odontology and pharmaceutical (even as drugs carrier) due to its chemical properties. Thus, it is considered a bioactive molecule being its internal consumption approved by the Food and Drug Administration (FDA). The aim of this study was to analyze the pharmacological effects of PEG
Publicado em: 2009
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9. Estudo das atividades neurotoxica e miotoxica de uma fosfolipase A2 basica isolada do veneno total Bothrops marajoensis / Study of neurotoxic and myotoxic activities of a phospholipase A2 isolated from the Bothrops marajoensis venom
In the present work, the neuromuscular effects of the toxin Bmaj-9 isolated from the venom of Bothrops marajoensis in the laboratory of chemistry of proteins at Unicamp were studied. This toxin was assayed in biventer cervicis preparations of little chicken, phrenic diaphragm nerve of mice and in gastrocnemius muscles of mice. In birds preparation, Bmaj-9 ca
Publicado em: 2008
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10. Isolation, purification and pharmalogical and biochemical characterization of a new PLA2 (Bp12) from Bothrops pauloensis venom / Isolamento, purificação e caracterização bioquimica e farmacologica de uma nova fosfolipase A2 (Bp12) do veneno de Bothrops pauloensis
The myotoxic effects caused by bothropics venoms are unquestionable by their exuberant clinic manifestation and are extensively related in literature, since the neurotoxic effects have been described in vitro conditions, in nerve-muscle preparations, with little or neither clinic evidence. The aim of this study was to contribute for the knowledge about the p
Publicado em: 2008
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11. Analise histologica do aparato venenifero e caracterização farmaco-bioquimica da peçonha de Vitalius dubius (Araneae, Theraphosidae) / Histological analysis of the venom apparatus and biochemical and pharmacological characterization of venom from Vitalius dubius (Araneae, Theraphosidae)
Vitalius dubius is a medium-sized, non-aggressive tarantula found in southeastern Brazil. In this work, we examined the histological organization of the venom apparatus of V. dubius and investigated some biochemical and pharmacological properties of this spider´s venom. The venom apparatus consisted of two chelicerae fitted with large fangs for prey immobil
Publicado em: 2008
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12. Pharmacological characterization of ASP49 PLA2 isolated from Bothrops pauloensis venom / Caracterização farmacologica de uma fosfolipase A2 ASP49 isolada do veneno de Bothrops pauloensis
Bothropic venom has several substances necessary to serpent survival, among them, one of the most widely studied are phospholipase A2 enzymes, that hydrolise sn-2 from membrane phospholipids, releasing lysophospholipids and fatty acids, which beyond playing a biological action in the lipid digestion process, also exhibit a wide variety of pharmacological eff
Publicado em: 2008