Placebo Design
Mostrando 1-12 de 171 artigos, teses e dissertações.
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1. A randomized clinical trial on inhaled ciclesonide for managing acute asthma in the emergency room
ABSTRACT BACKGROUND: Use of inhaled corticosteroids for managing acute asthma exacerbations has been tested since the 1990s. OBJECTIVE: To compare high doses of inhaled ciclesonide with systemic hydrocortisone for managing acute asthma exacerbations in the emergency department. DESIGN AND SETTING: Double-blind, randomized clinical trial in the public heal
Sao Paulo Medical Journal. Publicado em: 2022
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2. Long-term consequences of osteoporosis therapy with denosumab
ABSTRACT Denosumab (DMAb) is a human monoclonal antibody used as an antiresorptive drug in the treatment of osteoporosis. Approval at a dosage of 60 mg every 6 months was based on the results of the randomized, placebo-controlled trial (FREEDOM). The design of this 3-year study included an extension for up to 10 years. Those who were randomized to DMAb conti
Archives of Endocrinology and Metabolism. Publicado em: 2022
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3. Effect of two oral formulations of cannabidiol on responses to emotional stimuli in healthy human volunteers: pharmaceutical vehicle matters
Objective: To compare plasma concentrations of cannabidiol (CBD) following oral administration of two formulations of the drug (powder and dissolved in oil), and to evaluate the effects of these distinct formulations on responses to emotional stimuli in healthy human volunteers. Methods: In a randomized, double-blind, placebo-controlled, parallel-group desi
Brazilian Journal of Psychiatry. Publicado em: 2022
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4. The effects of macronutrients composition on hormones and substrates during a meal tolerance test in drug-naive and sitagliptin-treated individuals with type 2 diabetes: a randomized crossover study
ABSTRACT Objectives: To evaluate the effect of sitagliptin treatment in early type 2 diabetes mellitus (T2DM) and the impact of different macronutrient compositions on hormones and substrates during meal tolerance tests (MTT). Materials and methods: Half of the drug-naive patients with T2DM were randomly assigned for treatment with 100 mg of sitagliptin, q
Archives of Endocrinology and Metabolism. Publicado em: 2022
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5. Effects of curcumin on cardiovascular risk factors in obese and overweight adolescent girls: a randomized clinical trial
ABSTRACT BACKGROUND: Obese adolescents are at higher risk of development of cardiovascular risk factors and obesity in later life. Dietary intake of antioxidants, particularly curcumin, as an active ingredient of turmeric extract, may have noticeable effects on obesity and its important complications such as cardiovascular risk factors. Therefore, the aim
Sao Paulo Med. J.. Publicado em: 04/11/2019
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6. Preemptive Use of Piroxicam on Tooth Sensitivity Caused By In-Office Bleaching: A Randomized Clinical Trial
Resumo Este ensaio clínico avaliou o efeito do uso preemptivo do anti-inflamatório não-esteroidal piroxicam em dose única 30 minutos antes do clareamento de consultório na prevenção de sensibilidade dentária (SD) relatada pelos pacientes. Cinquenta pacientes foram submetidos a duas sessões de clareamento dental em consultório com peróxido de hidro
Braz. Dent. J.. Publicado em: 07/10/2019
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7. Crossover Studies of Pediatric Dental Sedation are Inappropriate
Resumo Pouco se sabe sobre o impacto de um delineamento cruzado nos desfechos de ensaios clínicos randomizados voltados ao comportamento de crianças durante tratamento odontológico. Este estudo objetivou avaliar o efeito da sequência de administração do sedativo, da droga em si e da idade dos participantes no comportamento de crianças que receberam du
Braz. Dent. J.. Publicado em: 22/07/2019
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8. What do Cochrane systematic reviews say about the management of irritable bowel syndrome?
ABSTRACT BACKGROUND: Irritable bowel syndrome (IBS) is a clinical disorder associated with high socioeconomic burden. Despite its importance, management of IBS remains difficult and several interventions have been hypothesized as beneficial for this condition. This study identified and summarized all Cochrane systematic reviews (SRs) about the effects of i
Sao Paulo Med. J.. Publicado em: 08/05/2019
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9. Effect of intracanal diode laser application and low-level laser therapy on CGRP change
Abstract: The aim of this study was to investigate the effect of a placebo, intracanal diode laser application, and low-level laser therapy (LLLT) on the change of the total amount of calcitonin gene-related peptide (CGRP) in the gingival crevicular fluid (GCF) (split-mouth study design). GCF sampling was performed on a contralateral tooth and experimental t
Braz. oral res.. Publicado em: 18/03/2019
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10. What do Cochrane systematic reviews say about the use of cannabinoids in clinical practice?
ABSTRACT BACKGROUND: The therapeutic effects of cannabinoid compounds have been the center of many investigations. This study provides a synthesis on all Cochrane systematic reviews (SRs) that assessed the use of cannabinoids as a therapeutic approach. DESIGN AND SETTING: Review of SRs, conducted in the Discipline of Evidence-Based Medicine, Escola Pauli
Sao Paulo Med. J.. Publicado em: 22/10/2018
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11. Acute melatonin administration enhances aerobic tolerance: an analysis of biochemical and hematological parameters
Abstract Aims This study is aimed at testing the acute melatonin administration (oral; 6 mg) on aerobic tolerance at cycloergometer and analyzing the consequences on biochemical and hematological parameters. Methods The maximal aerobic capacity intensity (iMAC) at cycloergometer of eleven male healthy men (24.18±3.92 years-old; 87.07±12.48 kg; 1.82±0.05
Motriz: rev. educ. fis.. Publicado em: 17/05/2018
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12. Effect of one time high dose “stoss therapy” of vitamin D on glucose homeostasis in high risk obese adolescents
ABSTRACT Objective To study the effect of using a one time high dose “stoss therapy” of vitamin D2 (ergocalciferol: VD2) on indices of insulin sensitivity {whole body sensitivity index: WBISI} and secretion {insulinogenic index: IGI} measured during an oral glucose tolerance test (OGTT) in obese adolescents with VDD (25 OHD; serum metabolite of vit D: <
Arch. Endocrinol. Metab.. Publicado em: 05/04/2018