Platelets Aggregation
Mostrando 1-12 de 396 artigos, teses e dissertações.
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1. BaltDC: purification, characterization and infrared spectroscopy of an antiplatelet DC protein isolated from Bothrops alternatus snake venom
Abstract Background: Snake venoms are a complex mixture of proteins, organic and inorganic compounds. Some of these proteins, enzymatic or non-enzymatic ones, are able to interact with platelet receptors, causing hemostatic disorders. The possible therapeutic potential of toxins with antiplatelet properties may arouse interest in the pharmacological areas.
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 08/02/2018
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2. High levels of LDL-C combined with low levels of HDL-C further increase platelet activation in hypercholesterolemic patients
High levels of low-density lipoprotein cholesterol (LDL-C) enhance platelet activation, whereas high levels of high-density lipoprotein cholesterol (HDL-C) exert a cardioprotective effect. However, the effects on platelet activation of high levels of LDL-C combined with low levels of HDL-C (HLC) have not yet been reported. We aimed to evaluate the platelet a
Braz J Med Biol Res. Publicado em: 28/11/2014
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3. Isolated biomolecules of pharmacological interest in hemostasis from Cerastes cerastes venom
Biomolecules from Cerastes cerastes venom have been purified and characterized. Two phospholipases isolated from Cerastes cerastes venom share 51% of homology. CC2-PLA2 exhibits antiplatelet activity that blocks coagulation. CCSV-MPase, a non-hemorrhagic Zn2+-metalloproteinase, significantly reduced the plasmatic fibrinogen level and hydrolyzes only its Bβ
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 01/05/2013
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4. Inovações metodológicas em hematologia clínica: uso da citometria de fluxo no estudo da ativação plaquetária na pré-eclâmpsia
Preeclampsia (PE) is a serious complication of pregnancy associated to maternal-fetal morbidity and mortality, whose etiology has not been established. In pure form, is characterized by the appearance, in normal pregnant women after the 20th week of gestation, hypertension and proteinuria. Hemostatic and inflammatory changes associated with normal pregnancy
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/02/2012
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5. Caracterização funcional e estrutural de uma nova fosfolipase A2 ácida de Bothrops moojeni / Functional and structural characterization of a new acidic phospholipase A2 from Bothrops moojeni
The phospholipase A2 (PLA2s) are enzymes that induce various pharmacological effects and usually correspond to a higher percentage of the protein content of snake venoms. Thus, isolation, biochemical, functional and structural characterization of PLA2s may generate important information for a better understanding of the pharmacological effects and toxicity i
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/01/2012
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6. Clonagem, expressão e caracterização de um inibidor de agregação plaquetária proveniente dos complexos salivares de sanguessugas Haementeria depressa. / Cloning, expression and characterization of a platelet aggregation inhibitor from Haementeria depressa leech salivary complexes.
Animais hematófagos possuem em sua saliva substâncias que permitem a fluidez do sangue, para o sucesso de sua alimentação. Com isso, têm sido descritos diversos componentes com atividades nos diferentes processos hemostáticos (coagulação, fibrinólise e agregação plaquetária). O complexo salivar da sanguessuga Haementeria depressa vem sendo estuda
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/09/2011
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7. Avaliação do papel da 5-hidroxitriptamina (5-HT) no processamento periférico da resposta nociceptiva
5-Hydroxytryptamine (5-HT, serotonin) is a cell-derived vasoactive amine, released primarily by platelets (in humans), mast cells (in rodents) and endothelial cells. It is a regulator of smooth muscle in the cardiovascular and gastrointestinal systems, an enhancer of platelet aggregation, and a neurotransmitter in the central nervous system. Although 5-HT is
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/02/2011
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8. Hematological abnormalities and 22q11.2 deletion syndrome
The 22q11.2 deletion syndrome (22q11DS) is a common genetic disease characterized by broad phenotypic variability. Despite the small number of studies describing hematological alterations in individuals with 22q11DS, it appears that these abnormalities are more frequent than previously imagined. Thus, the objective of our study was to report on a patient wit
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2011
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9. PROFILET OF THE ECTONUCLEOTIDASE ACTIVITY AND PLATELETS AGREGGATION IN SYSTEMIC ERYTHEMATOSUS LUPUS PATIENTS / PERFIL DA ATIVIDADE DE ECTONUCLEOTIDASES EM PLAQUETAS E AGREGAÇÃO PLAQUETÁRIA EM PACIENTES COM LÚPUS ERITEMATOSOS SISTÊMICO
Systemic Lupus Erythematosus (SLE) is a chronic inflammatory disease that affects mostly women in reproductive age and sometimes cause permanent damage. The development of cardiovascular disease, especially atherosclerosis, is the leading cause of death in SLE. However, its etiology and relationship with the development of atherosclerosis remain unknown. Sev
Publicado em: 2010
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10. Estudo comparativo entre agregação plaquetária por turbidimetria e impedância elétrica em relação a pacientes sob terapia antiplaquetária a base de ácido acetilsalicílico / Comparative study between platelet aggregation by turbidimetric and impedance methods in patients under acetylsalicilic acyd antiplatelet therapy
The adhesion of platelets in the blood vessel wall and subsequent aggregation are crucial events in both bleeding and thrombosis. The hyperaggregation (excessive aggregation) of platelets can cause the formation of a thrombus and subsequent occlusion of blood vessels leading to an ischemic process. Antiplatelet therapy with acetylsalicylic acyd reduces by 25
Publicado em: 2010
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11. Brain ischemia alters platelet ATP disphosphohydrolase and 5'-nucleotidase activities in naive and preconditioned rats
The effects of transient forebrain ischemia, reperfusion and ischemic preconditioning on rat blood platelet ATP diphosphohydrolase and 5'- nucleotidase activities were evaluated. Adult Wistar rats were submitted to 2 or 10 min of single ischemic episodes, or to 10 min of ischemia 1 day after a 2-min ischemic episode (ischemic preconditioning) by the four-ves
Publicado em: 2010
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12. Investigação das ectonucleotidases na diferenciação de macrófagos e na ativação de plaquetas : o papel da homocisteína
Extracellular nucleotides modulate a variety of biological actions via purinergic receptor activation. These effects are modulated by ectonucleotidases, such as ENTPDases and ecto-5´- NT/CD73, which hydrolyze ATP to adenosine in the extracellular milieu. In the cells of the immune system, the ATP can act as danger signaling whereas adenosine, the ATP breakd
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2010