Poliketide Antibiotics
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1. Total synthesis of (+)-crocacins "C" and"D": synthesis of the 6,6-spiroketals / Sintese total das (+)-crocacinas C e D : sintese dos fragmentos 6,6-espirocetal das espirofunginas A e B
Chapter 1 describes the asymmetric total synthesis of (+)-crocacin C (1.3) and D (1.4). The convergent total synthesis of (1.3) relies on the use of a regio- and stereoselective epoxidation of an allylic alcohol with m-CPBA followed by epoxide opening with Me2CuCNLi2 and a Stille cross-coupling between (E)-vinyl stannane (1.111) and (E)-vinyl iodide (+)-(1.1
Publicado em: 2004