Polymorphic Susceptibility
Mostrando 1-12 de 151 artigos, teses e dissertações.
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1. The polymorphic inheritance of DIO2 rs225014 may predict body weight variation after Graves’ disease treatment
ABSTRACT Objective: We aimed to investigate the role of DIO2 polymorphisms rs225014 and rs12885300 in Graves’ disease patients, mainly for controlling body weight following treatment. Subjects and methods: We genotyped 280 GD patients by the time of diagnosis and 297 healthy control individuals using a TaqMan SNP Genotyping technique. We followed up 141
Arch. Endocrinol. Metab.. Publicado em: 2020-12
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2. Functional status and severity of osteoarthritis in elderly is associated to the polymorphism of TNFA gene
Abstract Background: Osteoarthritis (OA) is a major musculoskeletal disease with high prevalence in the elderly. The study of genetic polymorphisms of inflammatory mediators involved in OA may contribute to the elucidation of the complex pathophysiology of this disease and identification of susceptibility individuals. Aim: This study aimed to evaluate the
Adv. rheumatol.. Publicado em: 29/07/2019
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3. Structural diversity and biological importance of ABO, H, Lewis and secretor histo-blood group carbohydrates
ABSTRACT ABO, H, secretor and Lewis histo-blood system genes control the expression of part of the carbohydrate repertoire present in areas of the body occupied by microorganisms. These carbohydrates, besides having great structural diversity, act as potential receptors for pathogenic and non-pathogenic microorganisms influencing susceptibility and resistanc
Rev. Bras. Hematol. Hemoter.. Publicado em: 2016-12
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4. Mechanisms of carbapenem resistance in endemic Pseudomonas aeruginosa isolates after an SPM-1 metallo-β-lactamase producing strain subsided in an intensive care unit of a teaching hospital in Brazil
Carbapenem-resistance mechanisms are a challenge in the treatment of Pseudomonas aeruginosa infections. We investigated changes in P. aeruginosa carbapenem-resistance determinants over a time period of eight years after the emergence of São Paulo metallo-β-lactamase in a university hospital in Rio de Janeiro, Brazil. Patients admitted to the intensive care
Mem. Inst. Oswaldo Cruz. Publicado em: 2016-09
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5. The 19-bp deletion polymorphism of dihydrofolate reductase (DHFR) and nonsyndromic cleft lip with or without cleft palate: evidence for a protective role
Objective Nonsyndromic cleft lip with or without cleft palate (NS-CL/P) are among the most common congenital birth defects worldwide. Several lines of evidence point to the involvement of folate, as well as folate metabolizing enzymes in risk reduction of orofacial clefts. Dihydrofolate reductase (DHFR) enzyme participates in the metabolic cycle of folate a
J. Appl. Oral Sci.. Publicado em: 2015-06
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6. Protein Expression and Codon 72 Polymorphism of TP53 Gene in Triple Negative Breast Cancer
A subgroup of tumor that has received attention is triple-negative breast cancer (TNBC), which presents phenotype of negative estrogen receptor, negative progesterone receptor and has no overexpression of HER2. TP53 acts as a tumor suppressor limiting the proliferation of damaged cells. A polymorphic site (rs1042522) of TP53 encodes either an arginine or a p
Braz. arch. biol. technol.. Publicado em: 2014-12
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7. Virulence profiles of Shiga toxin-producing Escherichia coli and other potentially diarrheagenic E.coli of bovine origin, in Mendoza, Argentina
This study described a group of strains obtained from a slaughter house in Mendoza, in terms of their pathogenic factors, serotype, antibiotype and molecular profile. Ninety one rectal swabs and one hundred eight plating samples taken from carcasses of healthy cattle intended for meat consumption were analyzed. Both the swab and the plate samples were proces
Braz. J. Microbiol.. Publicado em: 04/02/2014
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8. Variantes do gene CD226 associadas com a susceptibilidade ao diabetes mellitus tipo 1 autoimune / CD226 gene variants associated with susceptibility to type 1, immune mediated, diabetes
Recently, Genome Wide Association (GWA) studies identified a new locus, 18q22, as a canditate to Type 1 A, or immune mediated diabetes (T1AD) susceptibility. This locus harbors the CD226 gene, responsible for encoding the leukocyte adhesion molecule (CD226) involved in cell adhesion, differentiation of naïve CD4+T cells, cytotoxicity induced by natural kill
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/08/2012
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9. The relationship between genetic variability and the susceptibility of Biomphalaria alexandrina snails to Schistosoma mansoni infection
In the present study, Biomphalaria snails collected from five Egyptian governorates (Giza, Fayoum, Kafr El-Sheikh, Ismailia and Damietta), as well as reference control Biomphalaria alexandrina snails from the Schistosome Biological Supply Center (SBSC) (Theodor Bilharz Research Institute, Egypt), were subjected to species-specific polymerase chain reaction (
Memórias do Instituto Oswaldo Cruz. Publicado em: 2012-05
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10. Association of MICA gene polymorphisms with liver fibrosis in schistosomiasis patients in the Dongting Lake region
Major histocompatibility complex class I chain-related A (MICA) is a highly polymorphic gene located within the MHC class I region of the human genome. Expressed as a cell surface glycoprotein, MICA modulates immune surveillance by binding to its cognate receptor on natural killer cells, NKG2D, and its genetic polymorphisms have been recently associated with
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-03
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11. CaracterizaÃÃo fenotÃpica e genotÃpica, sensibilidade a antimicrobianos e detecÃÃo de gene de virulÃncia de cepas clÃnicas e ambientais de Burkholderia pseudomallei. / Genotyping, antimicrobial susceptibility and detection of virulence genes of clinical and environmental strains of Burkholderia pseudomallei isolated in Ceara.
Melioidosis is a serious infectious disease caused by Burkholderia pseudomallei, a Gram negative rod, commonly found in soil and water. The disease is endemic in Southeastern Asia and hyperendemic in Northern Australia. Despite the initiation of empiric therapy, mortality remains at 21% in patients with melioidosis in Australia. In Brazil, it is considered a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 04/11/2011
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12. Comparação genotípica e fenotípica de diferentes isolados clínicos e ambientais de Rhodotorula spp. / Genotypic and phenotypic comparisons among clinical and environmental isolates of Rhodotorula spp.
Introduction: Rhodotorula spp. are yeasts widely distributed in the environment and can colonize the human body at different anatomical locations. This emerging pathogen is capable of causing superficial and invasive infections in humans whereas bloodstream infection is the most commonly described in the literature. Mainly three species have been related to
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/08/2011