Polymorphism Loh
Mostrando 1-12 de 15 artigos, teses e dissertações.
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1. Avaliação Genético-Molecular do Carcinoma das Células Escamosas da Laringe / Assessing the Molecular and Genetic Aspects of Squamous Cell Carcinoma of the Larynx
A laringe é uma estrutura tubular do trato aero digestivo com a principal função de formação de sons, além de estar relacionada com a proteção das vias aéreas inferiores e deglutição dos alimentos. Qualquer patologia que acomete este órgão pode ocasionar diversos problemas em sua função fisiológica normal, com influência plena e direta no de
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 21/10/2009
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2. Assessing the Molecular and Genetic Aspects of Squamous Cell Carcinoma of the Larynx / Avaliação Genético-Molecular do Carcinoma das Células Escamosas da Laringe
The larynx is a structure of the upper aerodigestive tract responsible for the production of sounds as well as protecting the lower airways and helping during the normal act of swallowing. Any pathology which affects the larynx can impose several challenges that disrupt its normal physiological function, and consequently and directly resulting in reduction o
Publicado em: 2009
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3. Análise molecular dos genes FHIT (Fragile Histidine Triad) e ATR (Ataxia-Telangiectasia and Rad3 Related) em pacientes com câncer de mama.
O gene FHIT é um supressor tumoral envolvido com o crescimento, proliferação celular e apoptose, encontrando-se freqüentemente inativado em vários tipos de tumores. Em casos de câncer de mama, a perda ou a redução da expressão da proteína Fhit foi associada à progressão tumoral e ao pior prognóstico da doença. Recentemente, foi demonstrado que
Publicado em: 2008
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4. Implicações do gene TP53 do vírus do papiloma humano no câncer da próstata
The prostate gland can be assaulted by many pathologies. Among them the prostate cancer is the 2nd death cause on men older than 50 years old. Although the etiology of this disease is not well comprehended, the genetic alterations and the presence of infectious agents have been suggested as associated to the development of this cancer. One of the most freque
Publicado em: 2002
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5. Loss of heterozygosity on chromosomes 17 and 18 in breast carcinoma: two additional regions identified.
The loss of heterozygosity (LOH) at specific regions of the human genome in tumor DNA is recognized as evidence for a tumor-suppressor gene located within the corresponding region of the homologous chromosome. Restriction fragment length polymorphism analysis of a panel of primary human breast tumor DNAs has led to the identification of two additional region
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6. Evaluation of 13q14 Status in Patients with Chronic Lymphocytic Leukemia Using Single Nucleotide Polymorphism-Based Techniques
Deletions of chromosome 13q14 are common in chronic lymphocytic leukemia and other cancers, demonstrating the importance of this region in tumorigenesis. We report the use of two single-nucleotide polymorphism (SNP)-based techniques to determine 13q loss of heterozygosity (LOH) status in 15 patients with CLL: (i) digital SNP (dSNP), where analysis of heteroz
American Society for Investigative Pathology.
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7. Evaluation of 13q14 Status in Multiple Myeloma by Digital Single Nucleotide Polymorphism Technology
Chromosome 13q deletions are common in multiple myeloma and other cancers, demonstrating the importance of this region in tumorigenesis. We used a novel single nucleotide polymorphism (SNP)-based technique, digital SNP (dSNP), to identify loss of heterozygosity (LOH) at chromosome 13q in paraffin-embedded bone marrow biopsies from 22 patients with multiple m
American Society for Investigative Pathology.
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8. Use of non-radioactive detection in SSCP, direct DNA sequencing and LOH analysis
Aims—To develop a protocol that is applicable to single strand conformation polymorphism (SSCP), direct sequencing and loss of heterozygosity analysis of DNA.
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9. Demonstration of Loss of Heterozygosity by Single-Nucleotide Polymorphism Microarray Analysis and Alterations in Strain Morphology in Candida albicans Strains during Infection
Candida albicans is a diploid yeast with a predominantly clonal mode of reproduction, and no complete sexual cycle is known. As a commensal organism, it inhabits a variety of niches in humans. It becomes an opportunistic pathogen in immunocompromised patients and can cause both superficial and disseminated infections. It has been demonstrated that genome rea
American Society for Microbiology.
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10. Cytogenetic and molecular genetic studies of follicular and papillary thyroid cancers.
Cytogenetic studies have shown frequent clonal abnormalities in papillary carcinoma (PTC) and follicular carcinoma (FTC). Loss of heterozygosity (LOH) may suggest the presence of tumor suppressor genes and has not been reported in these neoplasms. These studies were undertaken to determine if consistent chromosomal abnormalities are associated with thyroid c
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11. Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: The predominant role of hMLH1
Fifteen to twenty-five percent of sporadic colorectal carcinomas are replication error (RER) positive. Because the frequency of mutations in the mismatch repair genes (hMLH1 and hMSH2) is low in these tumors, we have investigated the role of mutational inactivation, methylation of the promoter region, and loss of heterozygosity (LOH) as a possible explanatio
The National Academy of Sciences.
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12. Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms
Chromosomal abnormalities are frequent in myeloid malignancies, but in most cases of myelodysplasia (MDS) and myeloproliferative neoplasms (MPN), underlying pathogenic molecular lesions are unknown. We identified recurrent areas of somatic copy number–neutral loss of heterozygosity (LOH) and deletions of chromosome 4q24 in a large cohort of patients with m
American Society of Hematology.