Ppar Gamma
Mostrando 1-12 de 33 artigos, teses e dissertações.
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1. Dietary supplementation with gamma-linolenic, linoleic and oleic acids decreases PPAR-gamma expression and helps the tetracycline derivative to reduce NOD2 expression in patients with acne vulgaris
Anais Brasileiros de Dermatologia. Publicado em: 2022
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2. New PPARα/γ/δ Optimal Activator Rationally Designed by Computational Methods
The peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor that acts as a transcription factor, regulating glucose, lipid and inflammation signaling and it is exploited in type 2 diabetes treatment. However, the selective activation of this PPAR subtype has been linked to important adverse effects which can be mitigated through conco
J. Braz. Chem. Soc.. Publicado em: 2016-09
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3. Effect of Cottonseed Meal Fermented with Yeast on the Lipid-related Gene Expression in Broiler Chickens
ABSTRACT Fermented cottonseed meal (FCSM) is widely used in poultry diets in China. This study was conducted to investigate the effect of FCSM on lipid-related gene expression in broilers. Initially, 180 broiler chickens (21-days-old, equal number of males and females) were randomly divided into three groups, with six pens per group and 10 birds per pen. The
Rev. Bras. Cienc. Avic.. Publicado em: 2015-12
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4. Prevalence of the rs1801282 single nucleotide polymorphism of the PPARG gene in patients with metabolic syndrome
Objective This study aimed to get the genotypic and allelic frequencies of rs1801282 in 179 volunteer donors and 154 patients with Metabolic syndrome (MetS) in Brasilia, Brazil and also examine the association with anthropometric, biochemical and hemodynamic variables in the latter group. MetS comprises a group of diseases resulting from insulin resistance,
Arch. Endocrinol. Metab.. Publicado em: 2015-08
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5. Caracterização de agonistas do PPARγ através de ensaios celulares e biologia estrutural / Characterization of PPARγ agonists using cell based assays and structural biology
Os receptores nucleares são uma família de fatores de transcrição que regulam a transcrição gênica em resposta a ligantes e estão envolvidos em vários processos fisiológicos e metabólicos do organismo. O receptor ativado por proliferadores peroxissomais γ (PPARγ) está envolvido em vários processos fisiológicos incluindo adipogênese
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/08/2012
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6. Estudos estruturais do receptor ativado por ativadores de peroxissomos humano, hPPARδ / Structural studies of human peroxisome proliferator activated receptor, hPPARδ
Os PPARs são fatores de transcrição ativados por ligantes, pertencentes à superfamília dos receptores nucleares, que são considerados sensores de lipídeos capazes de transformar alterações nos padrões de lipídeos/ácidos graxos dos organismos em atividade metabólica. Com isto, os 3 isotipos (α, δ e γ) estão associados a diferen
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/03/2012
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7. Remodelamento do fígado, pâncreas e tecido adiposo em modelo experimental de síndrome metabólica tratado com telmisartana, sitagliptina e metformina / Hepatic, pancreatic and adipose tissue remodeling in an experimental model of metabolic syndrome treated with telmisartan, sitagliptin and metformin
Pharmacological intervention can minimize or even reverse adverse remodeling due to metabolic syndrome. This work sought to evaluate the effects of monotherapies and combinations of drugs on insulin sensitivity, adipose tissue morphology, pancreatic and hepatic remodelling in C57BL/6 mice fed a high-fat diet. Male C57BL/6 mice were fed a very high-fat diet (
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/06/2010
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8. Repercussões do destreinamento físico sobre o metabolismo e a celularidade do tecido adiposo branco periepididimal de ratos. / Physical detraining repercussions on metabolism and cellularity of white adipose tissue periepididymal in rats.
All adaptations acquired through physical training are reversible during inactivity. Significant reductions in maximal oxygen uptake (VO2Max) are observed within two-four weeks of detraining. Conversely, the consequences of detraining on adipose tissue are poorly known. The objective was to investigate the physical detraining effects on metabolism and cellul
Publicado em: 2010
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9. Interections between CD40/CD40L and PPARs signaling pathways / Interação entre as vias de sinalização CD40/CD40L e os PPARs
The membrane receptor CD40 and its ligand CD40L play an important role in the interface between innate and acquired immunity. Dysfunction of this signaling pathway was described in inflammatory and autoimmune diseases. In systemic lupus erythematosus (SLE), increased serum levels of soluble CD40L have been detected, where it plays a significant role in the g
Publicado em: 2008
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10. Effect of pioglitazone on the functional viability and apoptosis rate of culture murine pancreatic islets. / Efeito da pioglitazona sobre a viabilidade funcional e o índice de apoptose de ilhotas pancreáticas murídeas em cultura
Acredita-se que a diminuição progressiva da massa de células observada durante a evolução do diabetes mellitus tipo 2 (DM 2) ocorra por apoptose deste tipo celular. As tiazolidinedionas (TZDs), uma classe de medicamentos utilizada no tratamento do DM 2, atuam como ligantes dos receptores ativados por proliferadores de peroxissomos (PPAR) e e promovem di
Publicado em: 2008
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11. Intestino fetal de ratos expressa PPAR-GAMMA
Publicado em: 2007
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12. Vitamin E: characterization of the biological activity and relation with the nuclear receptor PPARy. / Vitamina E: caracterização da atividade biológica na resposta inflamatória induzida pelo LPS e sua relação com o receptor nuclear PPARy.
Vitamin E, a generic term to describe a group of structurally lipophilic molecules (tocopherols and tocotrienols), is one of the most known antioxidants and it has been studied also because its non-antioxidant roles. By the way, depending on the administered dose, -tocopherol can exert antagonic effects in vitro. Its known that PPAR, a nuclea
Publicado em: 2007