Presynaptic Inhibition
Mostrando 1-12 de 206 artigos, teses e dissertações.
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1. Effect of adenosine A2A receptor antagonists on motor disorders induced by 6-hydroxydopamine in rat
PURPOSE: To investigate the role of adenosine A2A receptors on 6-OHDA-induced motor disorder in rat. METHODS: In order to induce experimental model of Parkinson's disease, 6-hydoxydopamine (8 μg/rat) was injected unilaterally into the SNc. After three weeks as a recovery period, 6-OHDA-induced bradykinesia and balance disturbances were assessed by using
Acta Cir. Bras.. Publicado em: 2016-02
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2. Efeitos de diferentes freqüências e amplitudes de vibração unilateral do tendão calcâneo na orientação postural e no reflexo H em humanos / Effects of Achilles tendon vibration of different frequencies and amplitudes on postural orientation and H reflex in humans
A vibration applied to a muscle tendon increases the firing frequency of afferents of types Ia and II innervating muscle spindles, and hence affects the spinal cord circuits and this can affect motor control. The aim of this study was to analyze the effect of vibrations of two frequencies (15 and 80Hz) and two amplitudes (1 and 2.5 mm) applied to the right A
Publicado em: 2010
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3. Neural changes in the spinal cord rights for different types of physical training / Adaptações neurais na medula espinhal de humanos para diferentes tipos de treinamento físico
Introduction: Neural adaptations with physical training have been widely studied. The spinal cord is a possible locus of adaptation. However, longitudinal studies that evaluate directly the spinal cord pathways have not been found in the literature. Therefore, all reports from the literature justify changes found in measured responses to exercise by hypothes
Publicado em: 2009
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4. Atividade preparatória de circuitos neuronais medulares durante expectativa para contração muscular voluntária / Preparatory activity of spinal cord neuronal circuits for voluntary contraction
Antecedendo movimentos voluntariamente gerados, existe atividade neuronal encefálica que se inicia alguns segundos antes da execução deste movimento. Esta atividade preparatória é responsável pela elaboração de um plano de execução que alcança a via final comum para realização de um ato motor voluntário, os motoneurônios. Entretanto, na últim
Publicado em: 2007
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5. Neuromuscular activity of Bothrops neuwiedi pauloensis snake venom in mouse nerve-muscle preparations
The pharmacological effects of Bothrops neuwiedi pauloensis venom on mouse phrenic nerve-diaphragm (PND) preparations were studied. Venom (20 mug/ml) irreversibly inhibited indirectly evoked twitches in PND preparations (60 ± 10% inhibition, mean ± SEM; p<0.05; n=6). At 50 mug/ml, the venom blocked indirectly and directly (curarized preparations) evoked tw
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2005-03
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6. The pharmacological effect of Bothrops neuwiedii pauloensis (jararaca-pintada) snake venom on avian neuromuscular transmission
The neuromuscular effects of Bothrops neuwiedii pauloensis (jararaca-pintada) venom were studied on isolated chick biventer cervicis nerve-muscle preparations. Venom concentrations of 5-50 µg/ml produced an initial inhibition and a secondary increase of indirectly evoked twitches followed by a progressive concentration-dependent and irreversible neuromuscul
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-05
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7. Efeitos da peçonha de Bothrops neuwiedi pauloensis sobre preparações neuromusculares de ave e mamifero : aspectos miograficos e eletrofisiologicos
In the present study, the phannacological effects of Bothrops neuwiedi pauloensis venom were studied in mouse phrenic nerve-diaphragm and chick biventer cervicis preparations. In chick preparations, venom (1, 5, 10,50 and 100 J.1g1ml) produoed progressive, concentration-dependent neuromuscular blockade. At low venom concentrations (1, 5, 10 and 20 J.1g1m1) ,
Publicado em: 2003
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8. Presynaptic inhibition in Aplysia involves a decrease in the Ca2+ current of the presynaptic neuron.
By voltage clamping presynaptic cell L10 and using pharmacologic separation techniques, we have analyzed the specific ionic currents in the presynaptic cell that correlate with presynaptic inhibition while assaying transmitter release with intracellular recordings from postsynaptic cells. We have found that presynaptic inhibition can be elicited in condition
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9. Endogenous regulators of G protein signaling proteins regulate presynaptic inhibition at rat hippocampal synapses
Presynaptic inhibition mediated by G protein-coupled receptors (GPCRs) can develop and decay in a few seconds. This time course is too rapid to be accounted for by the intrinsic GTPase activity of Gα subunits alone. Here, we test the hypothesis that endogenous regulators of G protein signaling (RGS proteins) are required for rapid, brief presynaptic in
The National Academy of Sciences.
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10. Changes in presynaptic inhibition of Ia fibres at the onset of voluntary contraction in man.
1. Two independent methods were used, in man, to assess changes in presynaptic inhibition of I a terminals at the onset of selective voluntary contractions: (1) measurement of the amount of heteronymous monosynaptic I a facilitation (from the quadriceps muscle to soleus motoneurones) to provide an assessment of the amount of ongoing presynaptic inhibition ex
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11. Evidence for cutaneous and corticospinal modulation of presynaptic inhibition of Ia afferents from the human lower limb.
1. Presynaptic inhibition of soleus muscle Ia afferent fibres, produced by stimulation of group I afferents in the common peroneal nerve, was assessed from changes in the H reflex at long conditioning intervals, in six normal subjects. 2. Stimulation of the ipsilateral sural nerve at the malleolus, just before stimulation of the common peroneal nerve at the
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12. The role of GABAA and GABAB receptors in presynaptic inhibition of Ia EPSPs in cat spinal motoneurones.
1. The role of GABAA and GABAB receptors in presynaptic inhibition was studied by examining the effect of local application of antagonists by ionophoresis during intracellular recording of presynaptic inhibition of compound and unitary group Ia afferent excitatory postsynaptic potentials (EPSPs) in gastrocnemius motoneurones. 2. Ionophoresis of the GABAA ant