Primary Resistance Mutation
Mostrando 1-12 de 110 artigos, teses e dissertações.
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1. The role of gyrA and parC mutations in fluoroquinolones-resistant Pseudomonas aeruginosa isolates from Iran
Abstract The aim of this study was to examine mutations in the quinolone-resistance-determining region (QRDR) of gyrA and parC genes in Pseudomonas aeruginosa isolates. A total of 100 clinical P. aeruginosa isolates were collected from different university-affiliated hospitals in Tabriz, Iran. Minimum inhibitory concentrations (MICs) of ciprofloxacin and lev
Braz. J. Microbiol.. Publicado em: 2016-12
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2. Novel point mutations in the ERG11 gene in clinical isolates of azole resistant Candida species
The azoles are the class of medications most commonly used to fight infections caused by Candida sp. Typically, resistance can be attributed to mutations in ERG11 gene (CYP51) which encodes the cytochrome P450 14α-demethylase, the primary target for the activity of azoles. The objective of this study was to identify mutations in the coding region of theERG1
Mem. Inst. Oswaldo Cruz. Publicado em: 15/03/2016
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3. Primary resistance of HIV to antiretrovirals among individuals recently diagnosed at voluntary counselling and testing centres in the metropolitan region of Recife, Pernambuco
Determining the prevalence and type of antiretroviral (ARV) resistance among ARV-naïve individuals is important to assess the potential responses of these individuals to first-line regimens. The prevalence of primary resistance and the occurrence of recent infections among individuals with human immunodeficiency virus (HIV)/acquired immune deficiency syndro
Memórias do Instituto Oswaldo Cruz. Publicado em: 2012-06
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4. Assessing subtypes and drug resistance mutations among HIV-1 infected children who failed antiretroviral therapy in Kelantan, Malaysia
Antiretroviral (ARV) therapy has dramatically reduced morbidity and mortality in human immunodeficiency virus 1 (HIV-1) infected children. However, development of ARV resistance in these children is a major public health problem due to lack of availability of and access to new drugs. This study was conducted in order to identify circulating HIV subtypes and
Brazilian Journal of Infectious Diseases. Publicado em: 2012-06
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5. Characterization of gyrA and gyrB mutations and fluoroquinolone resistance in Mycobacterium tuberculosis clinical isolates from Hubei Province, China
OBJECTIVE: The study aimed to investigate gyrA and gyrB mutations in Mycobacterium tuberculosis (MTB) clinical strains from 93 patients with pulmonary tuberculosis in Hubei Province, China, and analyze the association between mutation patterns of the genes and ofloxacin resistance level. RESULTS: Among 93 MTB clinical isolates, 61 were ofloxacin-resistant by
Brazilian Journal of Infectious Diseases. Publicado em: 2012-04
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6. Caracterização biológica e molecular de recombinantes naturais de HIV-1. / Biological and molecular characterization of HIV-1 natural recombinants.
Recombination during reverse transcription is an important factor promoting HIV-1 diversity and adaptive change, allowing advantageous mutations arising on different genomes to undergo linkage in the same progeny recombinant genome more frequently than what would be expected under random mutation alone. In Brazil, several recombinant viruses were reported, a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/05/2011
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7. Resistência primária aos antirretrovirais e diversidade genética do HIV-1 em pacientes do estado do Tocantins. / HIV-1 Primary Antiretroviral Resistance and Genetic Diversity in Patientsn Of Tocantins State, Brazil
Diferenças regionais na epidemiologia molecular do HIV-1 têm sido descritas no Brasil e publicações sobre a epidemia da região Norte do país são restritas. Apesar do grande número de drogas antirretrovirais (ARV) das classes inibidores nucleosídicos e não-nucleosídicos (INTR e INNTR) da transcriptase reversa e inibidores da protease (IP), mutaçõ
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 21/02/2011
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8. Resistência primária aos antirretrovirais e diversidade genética do HIV-1 em pacientes do estado do Tocantins. / HIV-1 Primary Antiretroviral Resistance and Genetic Diversity in Patientsn Of Tocantins State, Brazil
Diferenças regionais na epidemiologia molecular do HIV-1 têm sido descritas no Brasil e publicações sobre a epidemia da região Norte do país são restritas. Apesar do grande número de drogas antirretrovirais (ARV) das classes inibidores nucleosídicos e não-nucleosídicos (INTR e INNTR) da transcriptase reversa e inibidores da protease (IP), mutaçõ
Publicado em: 2011
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9. Genetic analysis of protease and reverse transcriptase of HIV-1 from Southern Brazil naïve clinical isolates
Background: Rio Grande do Sul, the southernmost state of Brazil, presents an atypical epidemiological situation where HIV-1 subtype C co-circulates with subtypes B and CRF31_BC, contrasting with the other Brazilian regions were subtypes B and F dominates. These infections have been effectively managed with highly active antiretroviral therapy (HAART) since 1
Publicado em: 2010
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10. Molecular monitoring of patients with chronic myeloid leukemia treated with imatinib mesylate and evaluation of treatment resistance mechanisms: mutation of BCR-ABL and expression of MDR1 and BCRP genes / Acompanhamento molecular de pacientes com leucemia mielóide crônica tratados com mesilato de imatinibe e avaliação dos mecanismos de resistência ao tratamento: mutação do gene BCR-ABL e expressão dos genes MDR1 e BCRP
Chronic myeloid leukemia is characterized by t(9;22) translocation. The chimeric gene BCR-ABL encodes a p210BCRABL protein with constitutive tyrosine kinase activity which is directly related to CML pathogenesis. The imatinib mesylate, a tyrosine kinase inhibitor, is the first-choice treatment for patients in chronic phase but some patients show primary resi
Publicado em: 2009
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11. Efeitos de acidos graxos na indução de inflamação hipotalamica / Effects of fatty acids on the induction of hypothalamic inflammation
In animal models of diet-induced obesity, the activation of an inflammatory response in the hypothalamus produces molecular and functional resistance to the anorexigenic hormones insulin and leptin. The primary events triggered by dietary fats that ultimately lead to hypothalamic cytokine expression and inflammatory signaling are unknown. Here, we test the h
Publicado em: 2009
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12. Análise de Impacto do Polimorfismo Genético do Subtipo C do HIV-1 na Interação da Protease Viral com o Inibidor Nelfinavir por Modelagem e Dinâmica Molecular / Analyse the Impact of Genetic Polymorphism of subtype C of HIV-1 Protease Inhibitors in the Interaction Viral With the Inhibitor Nelfinavir by Modeling and Molecular Dynamics
The human immunodeficiency virus (HIV) can be divided into HIV-1 and HIV-2. The former can be divided into groups: M, N and O. Group M, which represents 90% of infections, is divided into several subtypes (A, B, C, D, F, G, H, J and K). It is known today that the most prevalent subtype in the world (and in Africa) is the subtype C, although the most studied
Publicado em: 2008