Procaine
Mostrando 1-12 de 176 artigos, teses e dissertações.
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1. In silico Evaluation of Cucurbit[6]uril as a Potential Detector for Cocaine and Its Adulterants Lidocaine, Caffeine, and Procaine
Illicit drugs and their trafficking require worldwide efforts in investigation, detection, and control. Colorimetric tests are often applied to identify drugs. Cocaine has some well-known adulterants that can provide a false positive response. Cucurbit[6]uril (CB[6]) has been suggested as a potential detector for cocaine and other illicit drugs. This work us
J. Braz. Chem. Soc.. Publicado em: 2021-04
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2. Development of a Molecularly Imprinted Modified Electrode to Evaluate Phenacetin Based on the Preconcentration of Acetaminophen
A glassy carbon electrode modified with a molecularly imprinted polymer (MIP) containing phenacetin recognition sites is introduced. The phenacetin-selective MIP was synthesised based on the electropolymerisation of pyrrole in a 1:1 (v/v) water/ethanol with HClO4 solution. The MIP-modified electrode showed higher recognition ability in comparison with a bare
J. Braz. Chem. Soc.. Publicado em: 2016-01
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3. INVESTIGAÇÃO DO USO DE ELETRODO DE CARBONO VÍTREO MODIFICADO COM HEXACIANOFERRATO DE RUTÊNIO PARA DETECÇÃO DE PROCAÍNA
A glassy carbon electrode modified with ruthenium hexacyanoferrate (RuOHCF) was investigated as an electrocatalyst for the detection of procaine with the aim of quantification in pharmaceutical and forensic samples. The RuOHCF films were prepared by electrochemical deposition, and the parameters used in this process (concentration of RuCl3, K3Fe(CN)6, temper
Quím. Nova. Publicado em: 2015-01
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4. Effects of eugenol on resting tension of rat atria
In cardiac and skeletal muscle, eugenol (μM range) blocks excitation-contraction coupling. In skeletal muscle, however, larger doses of eugenol (mM range) induce calcium release from the sarcoplasmic reticulum. The effects of eugenol are therefore dependent on its concentration. In this study, we evaluated the effects of eugenol on the contractility of isol
Braz J Med Biol Res. Publicado em: 21/03/2014
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5. Estudo do teste de Scott via técnicas espectroscópicas: um método alternativo para diferenciar cloridrato de cocaína e seus adulterantes
Cocaine is usually seized mixed with a wide variety of adulterants such as benzocaine, lidocaine, caffeine, and procaine. The forensic identification of cocaine in these street drug mixtures is normally performed using colorimetric testing kits, but these tests may suffer from interferences, producing false-positive results. Here, we describe the use of anal
Quím. Nova. Publicado em: 2014
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6. Estudo da relação quantitativa entre a estrutura química e a atividade antimicrobiana de cloretos de N,N[(dimetilamino)etil] benzoatos para e meta substituídos avaliada contra Saccharomyces cerevisiae (BY4741) e Escherichia coli (DH5α) / Quantitative structure activity relationships studies for antimicrobial activity of para and meta substituted N,N-[(dimethylaminoethyl) benzoates chlorides evaluated against Saccharomyces cerevisiae (BY4741) and Escherichia coli (DH5α).
No presente trabalho, destinado a tese de doutorado, desenvolvemos um estudo da relação entre a estrutura química e atividade antimicrobiana de duas séries, a saber: Série I - quatorze cloretos N,N[(dimetilamino)etil]-benzoatos para-substituídos, onde R4 = H, CH3, C2H5, nC4H9, tC4H9, OCH3, nOC4H9, COCH3, Cl, CN, NO2, OC6H13, SO2Me, CF3 (compostos I.1 a
Publicado em: 2009
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7. Influencia dos anestesicos locais no bloqueio neuromuscular produzido por diferentes bloqueadores neuromusculares : estudo experimental / The influence of local anesthetics on neuromuscular blockade produced by differents neuromusculars blockades : experimental study
Local anesthetics commonly used in clinical practice can interact with neuromuscular blockers and potentiate their effects. Many authors studied this interaction, but the mechanism involved in the potentiation of neuromuscular blockers and the action of local anesthetics in the pre and postjunctional sites were not completely elucidated- In this study, in sp
Publicado em: 2006
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8. Comparative study of the hydrophobic and ionization parameters of a series of procaine derivatives with neuromuscular blocking activity / Estudo comparativo de parâmetros hipidrofóbicos e, relacionados à ionização, de série de derivados da procaína com atividade bloqueadora neuromuscular
O estudo das Relações Quantitativas entre Estrutura química e Atividade biológica (QSAR/QSAR-3D) utilizando diferentes estratégias metodológicas complementares, aplicadas iterativamente, se estende a diferentes áreas de aplicação. Dentre elas destaca-se o planejamento racional de novos fármacos e o estudo de seus mecanismos de ação. Moléculas ca
Publicado em: 2003
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9. Efeito colateral da anestesia local subcutânea com vasoconstritores em bovinos
In order to study the effects of different local anaesthetics with and without vasoconstritor (epinefrine), 20 adult crossbred cows were used. The following treatments were carried out:T1 - control (bidistilled water); T2 - chloridrate of lidocaine (20 mg/ml) with epinephrine (0.005 mg/ml); T3 - chloridrate of lidocaine (20 mg/ml) with epinephrine (0.02 mg/m
Arquivo Brasileiro de Medicina Veterinária e Zootecnia. Publicado em: 2000-10
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10. Sites of action of procaine at the motor end-plate.
The effects of procaine at pH 7.4 and 9.9 were studied by examining the decay phase of spontaneous miniature end-plate currents (m.e.p.c.s) recorded from toad sartorius muscle fibres. Following exposure to procaine (0.05-0.1 mM) at pH 7.4, the decay of m.e.p.c.s rapidly became biphasic, and could be described as the sum of two exponential components. When th
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11. Effects of procaine and caffeine on calcium release from the sarcoplasmic reticulum in frog skeletal muscle.
1. Resting myoplasmic free [Ca2+] and [Ca2+] transients (delta [Ca2+]) were measured in single voltage-clamped frog skeletal muscle fibres in the presence and absence of procaine, caffeine or procaine plus caffeine using Fura-2 fluorescence and antipyrylazo III (Ap III) absorbance signals. The rate of release (Rrel) of calcium from the sarcoplasmic reticulum
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12. Effects of procaine on calcium accumulation by the sarcoplasmic reticulum of mechanically disrupted rat cardiac muscle.
The ability of the sarcoplasmic reticulum of skinned cardiac muscle of the rat to accumulate and release Ca2+ was studied in the presence and absence of procaine. Ca2+ accumulation was estimated from the magnitude of the caffeine- (30 mM) induced force transient in a weakly Ca2+ buffered solution. The relative area under the caffeine-induced force transient