Protein Degradation
Mostrando 1-12 de 4128 artigos, teses e dissertações.
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1. Effects of antidiabetics and exercise therapy on suppressors of cytokine signaling-1, suppressors of cytokine signaling-3, and insulin receptor substrate-1 molecules in diabetes and obesity
SUMMARY OBJECTIVE: Pathological destruction of insulin signaling molecules such as insulin receptor substrate, especially due to the increase in suppressors of cytokine signaling molecules, has been demonstrated in experimental diabetes. The contribution of suppressors of cytokine signaling proteins to the development of insulin resistance and the effects o
Revista da Associação Médica Brasileira. Publicado em: 2023
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2. Gene Silencing Therapeutics in Cardiology: A Review Article
Abstract Therapeutics that inhibit enzymes, receptors, ion channels, and cotransporters have long been the mainstay of cardiovascular medicine. Now, oligonucleotide therapeutics offer a modern variation on this paradigm of protein inhibition. Rather than target a protein, however, small interfering ribonucleic acids and antisense oligonucleotides target the
International Journal of Cardiovascular Sciences. Publicado em: 2022
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3. Potential and restrictions of Poincianella pyramidalis (Tul.) L. P. Queiroz as native forage in the Brazilian semi-arid region
ABSTRACT. Poincianella pyramidalis (catingueira) is a endemic plant of the Caatinga, selected by animals grazing on native pasture. With the aim of evaluating characteristics indicative of its nutritional quality, 10 plants were selected and identified, sampled at five different ages, were used to determine dry matter (DM), crude protein (CP), neutral deterg
Acta Sci., Anim. Sci.. Publicado em: 24/10/2020
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4. Synthesis of ZnO Nanoparticles by the Sol-Gel Protein Route: A Viable and Efficient Method for Photocatalytic Degradation of Methylene Blue and Ibuprofen
The photocatalytic degradation of methylene blue dye and ibuprofen drug was studied in the presence of zinc oxide, synthetized by the protein sol-gel route. The catalyst, calcined at 1000 ºC, presented a tendentious morphology to filaments characteristic of ZnO crystalline, characterized by X-ray diffraction (XRD) and confirmed by the presence of Zn energy
J. Braz. Chem. Soc.. Publicado em: 2020-08
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5. Rumen-protected methionine in cattle: influences on reproduction, immune response, and productive performance
RESUMO: Atualmente, as informações e o conhecimento gerado sobre os principais ingredientes utilizados em dietas para bovinos possibilitaram maior assertividade em suas formulações. Dentre esses ingredientes, os aminoácidos se destacam como uma ferramenta promissora, capaz de levar à redução nos níveis totais de proteína bruta e ajustar as concentr
Arq. Inst. Biol.. Publicado em: 25/11/2019
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6. [RETRACTED ARTICLE] Ginsenoside Rd inhibits IL-1β-induced inflammation and degradation of intervertebral disc chondrocytes by increasing IL1RAP ubiquitination
Many compounds of ginsenosides show anti-inflammatory properties. However, their anti-inflammatory effects in intervertebral chondrocytes in the presence of inflammatory factors have never been shown. Increased levels of pro-inflammatory cytokines are generally associated with the degradation and death of chondrocytes; therefore, finding an effective and non
Braz J Med Biol Res. Publicado em: 12/08/2019
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7. Gene expression during the germination of coffee seed
Resumo: A germinação da semente do café (Coffea arabica L.) é resultado de eventos que ocorrem simultaneamente no embrião e endosperma. Para entender os mecanismos moleculares responsáveis por estes eventos, nós realizamos uma análise transcricional do embrião e dos endospermas micropilar e lateral de sementes embebidas por 10 dias. O sequenciamento
J. Seed Sci.. Publicado em: 01/07/2019
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8. Kinetic study of the effect of kiwi fruit actinidin on various proteins of chicken meat
Abstract In this research, the effect of kiwi protein on the physicochemical properties of chicken meat was investigated (Ross breed). Chicken thighs have been marinated in the form of cubes with dimensions of 2 cm in 20 mL of kiwi protein with activity of 0.9 u/mL for 2, 4, 6, 8, 24, 48, 72, and 96 hr, and kept in a refrigerator at 4 ± 1 °C. Then, the enz
Food Sci. Technol. Publicado em: 27/06/2019
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9. In Silico Characterization of Meloidogyne Genus Nematode Cellulose Binding Proteins
Abstract Root-knot nematodes are a group of endoparasites species that induce the formation of giant cells in the hosts, by which they guarantee their feeding and development. Meloidogyne species infect over 2000 plant species, and are highly destructive, causing damage to many crops around the world. M. enterolobii is considered the most aggressive species
Braz. arch. biol. technol.. Publicado em: 13/05/2019
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10. Nutritional value of dehydrated maize straw ammoniated with urea
RESUMO Objetivou-se avaliar a composição químico bromatológica e degradação in situ da matéria seca da palha de milho amonizada com ureia. Adotou-se delineamento inteiramente casualizado com cinco níveis de amonização (0; 2; 4; 6 e 8% da matéria seca), com cinco repetições. Verificou-se efeito (P<0,05) do processo de amonização sobre a retenç
Rev. bras. saúde prod. anim.. Publicado em: 04/04/2019
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11. MicroRNAs: new biomarkers and promising therapeutic targets for diabetic kidney disease
Resumo A doença renal do diabetes (DRD) é uma complicação crônica do diabetes mellitus associada à elevada morbidade e mortalidade, considerada um problema de saúde mundial. Dentre os fatores associados ao desenvolvimento e à progressão da DRD, destacam-se os microRNAs, que consistem em pequenas moléculas de RNA que regulam a expressão gênica por
J. Bras. Nefrol.. Publicado em: 07/02/2019
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12. Sunflower cake in diets for beef cattle: digestibility, kinetics and in vitro ruminal fermentation parameters
ABSTRACT. The objective of this study was to evaluate the effect of the inclusion of sunflower cake replacing soybean meal in beef cattle diets on the in vitro digestibility of dry matter (IVDDM), organic matter (IVDOM), crude protein (IVDCP) and the ruminal fermentation kinetics and parameters. The experiment was analyzed according to a completely randomize
Acta Sci., Anim. Sci.. Publicado em: 07/01/2019