Protein Ligand Interactions
Mostrando 1-12 de 438 artigos, teses e dissertações.
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1. Estudos biofísicos de chaperonas de secreção e de interações proteína-ligante / Biophysical studies on secretion chaperones and protein-ligand interactions
So far, the Xanthomonas axonopodis pv. citri (XAC) mechanisms of bacterial virulence is unknown. It is believed that secretion chaperones (CS) are involved in the XAC´s virulence process by first forming complexes with virulence factors, and assisting in their presentation to corresponding secretion systems using ATP as a source of energy. Fluorescence emis
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/03/2012
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2. Mimotopes selected by biopanning with high-titer HIV-neutralizing antibodies in plasma from Chinese slow progressors
OBJECTIVE: One approach to identifying HIV-1 vaccine candidates is to dissect the natural antiviral immune response in treatment-naïve individuals infected for over ten years, considered slow progressor patients (SPs). It is suspected that SP plasma has strongly neutralizing antibodies (NAb) targeting specific HIV viral epitopes. METHODS: NAbs levels of 11
Braz J Infect Dis. Publicado em: 2012-12
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3. Análise estrutural do domínio de reconhecimento a carboidratos da lectina Dvirl de Dioclea virgata e sua correlação na indução da produção de óxido nítrico / Structural analysis of the carbohydrate recognition domain the DvirL lectin from Dioclea virgata and its correlation in the induction of nitric oxide production
Lectins are defined as proteins or glycoproteins of nonimmune origin that have at least one site of reversible binding to carbohydrates or glycoconjugates. Lectins of plant origin are the most studied and characterized as three-dimensional structure and biological functions related. Lectins can be found in different parts of the plant from its root to the in
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/07/2011
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4. Immobilization and sensing ability of human thyroid nuclear receptor in nanostructured thin films / Estudo da imobilização do receptor tireoidiano humano TRβ1 em filmes finos nanoestruturados e aplicações em detecção de hormônios tireoidianos
Manipulation of materials at the nanoscale represents one of the frontiers in nanoscience and nanotechnology, mainly due to the possibility of specific controlling, improved properties, not observed if conventional bulk processing is applied. For biomolecules, in particular, processing via immobilization in the form of nanostructured films has allowed their
Publicado em: 2010
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5. Cromatografia negativa em Sepharose-TREN como tecnica de purificação de proteinas adicionadas artificialmente a extrato de soja / Negative chromatography on Sepharose-TREN as a technique of proteins purification artificially added to soybean extract
In recent years, plants have been studied as bioreactors for the production of recombinant proteins with industrial and pharmaceutical interest. When compared to other expression systems, plants have several advantages, such as the possibility of posttranlationals modification, low production cost, low risk of contamination by human pathogens, and the accumu
Publicado em: 2009
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6. Estudo da modelagem molecular do receptor canabinóide CB1 e suas interações com o ∆9 - THC / Molecular modeling study of CB1 cannabinoid receptor and its interaction with delta-9-THC
Marijuana (Cannabis sativa) is a widely used plant and its various applications have important benefits. The plant Cannabis sativa has been used by man for centuries for eating, medicinal practices and religious rituals. In human subjects, its effects include analgesia, alterations in perceptions, cognition, memory and psychomotor activity. The cannabinoid c
Publicado em: 2009
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7. Glutamate receptors as seen by light: spectroscopic studies of structure-function relationships
Ionotropic glutamate receptors are major excitatory receptors in the central nervous system and also have a far reaching influence in other areas of the body. Their modular nature has allowed for the isolation of the ligand-binding domain and for subsequent structural studies using a variety of spectroscopic techniques. This review will discuss the role of s
Brazilian Journal of Medical and Biological Research. Publicado em: 2007-11
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8. Recent NMR techniques applied to protein-ligand interactions and metabonomics / Tecnicas de RMN recentes aplicadas as interações proteina-ligante e a metabonomica
Durante as últimas décadas, muitos métodos de RMN de H foram desenvolvidos e aplicados para triagem e caracterização de interações intermoleculares e para a metabonômica. Estes são temas recentes da RMN e ambos serão abordados em dois capítulos distintos neste trabalho. No Capítulo 1 foi realizada a implantação e otimização de técnicas de RM
Publicado em: 2006
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9. Internalização e tráfego da Stress Inducible Protein-1 (STI-1), um ligante da proteína prion celular
The cellular prion protein (PrPc) is a glycosylphosphatidylinositol (GPI)-anchored plasma membrane glycoprotein. The PrPc abnormal isoform, PrPsc, is an infectious form involved in the prion disease pathogenesis. Identification of ligands that interact with PrPc can help in the understanding the physiological function of this protein. The STI-1 (stress induc
Publicado em: 2006
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10. Structural studies of the thyroid receptor (TR) and homology modeling of the thyroxine binding globulin (TBG) / Estudos estruturais do receptor do hormônio tireoidiano (hTR) e modelagem por homologia da globulina de ligação à tiroxina (TBG)
The thyroid hormones are involved in various regulatory effects, on diverse organs. Their fluctuations on the body are related to clinical scenarios of great relevance. This work deals with the study of two proteins which are directly related to the regulatory system associated to these hormones. The first one is the thyroxine-binding globulin (TBG), respons
Publicado em: 2005
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11. Estudo QSAR de inibidores da secreção gastrica e simulação molecular da inibição
O estudo QSAR de inibidores da secreção gástrica e simulação molecular da inibição consiste em quatro fases. Na fase um busca-se validação dos métodos de simulação de solvatação. Na fase dois, a elaboração de modelos de relações quantitativas entre estrutura química e atividade biológica (QSAR) para compostos moduladores da secreção gá
Publicado em: 2004
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12. Ubiquitous overexpression of a transgene encoding the extracellular portion of the Drosophila Roughest-Irregular Chiasm C protein induces early embryonic lethality
The cell adhesion molecule Rst-irreC is a transmembrane glycoprotein of the immunoglobulin superfamily involved in several important developmental processes in Drosophila, including axonal pathfinding in the optic lobe and programmed cell death and pigment cell differentiation in the pupal retina. As an initial step towards the "in vivo'' functional analysis
Anais da Academia Brasileira de Ciências. Publicado em: 2000-09