Pterocarpans
Mostrando 1-11 de 11 artigos, teses e dissertações.
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1. Natural products as new antimitotic compounds for anticancer drug development
Cell cycle control genes are frequently mutated in cancer cells, which usually display higher rates of proliferation than normal cells. Dysregulated mitosis leads to genomic instability, which contributes to tumor progression and aggressiveness. Many drugs that disrupt mitosis have been studied because they induce cell cycle arrest and tumor cell death. Thes
Clinics. Publicado em: 10/12/2018
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2. Activity of Fabaceae species extracts against fungi and Leishmania: vatacarpan as a novel potent anti-Candida agent
AbstractLeishmaniasis and fungal infection treatment efficacy is limited by toxicity and ever increasing resistance to available drugs, requiring development of alternative compounds. The richness of Cerrado plant antimicrobial secondary metabolites justifies screening of Fabaceae species extracts: Enterolobium ellipticum Benth., Sclerolobium aureum (Tul.) B
Rev. bras. farmacogn.. Publicado em: 2015-08
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3. Inhibition of Saccharomyces cerevisiae Pdr5p by a natural compound extracted from Brazilian Red Propolis
Multidrug resistance of cancer cells and pathogenic microorganisms leading to the treatment failure of some forms of cancer or life-threatening bacterial or fungal infections is often caused by the overexpression of multidrug efflux pumps belonging to the ATP-binding cassette transporters superfamily. The multidrug resistance of fungal cells often involves t
Revista Brasileira de Farmacognosia. Publicado em: 12/08/2011
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4. AvaliaÃÃo da atividade da cabenegrina A-II frente Ãs alteraÃÃes bioquÃmicas e hematolÃgicas e aos efeitos pressÃricos induzidos pelo veneno de Bothrops jararacussu em ratos. / Activity of cabenegrin A-II in biochemical, hematological and pressure effects induced by bothrops jararacussu snake venom in rats.
O uso de plantas medicinais no tratamento de picadas de serpentes à amplamente difundido nas culturas populares ao redor do mundo. Esta prÃtica pode ser Ãtil no tratamento primÃrio de vÃtimas de acidentes ofÃdicos, principalmente em Ãreas onde o soro antiveneno nÃo està prontamente disponÃvel. Os pterocarpanos, especialmente as cabenegrinas A-I e A
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/07/2009
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5. Pterocarpans and a novel flavanone from harpalyce brasiliana roots
A nova '(-)-7,8,3',4'-tri-hidróxi-8-(3'',7''-dimetil-octa-2'',6''-dienoil)-flavanona foi isolada a partir do extrato etanólico das raízes de Harpalyce brasiliana, juntamente com os pterocarpanos conhecidos (-)-2-geranil-3-hidróxi-8,9-metilenodioxipterocarpano, harpalicina, medicarpina, maackiaina e as cabenegrinas A-I e A-II. Os metabólitos isolados for
Journal of the Brazilian Chemical Society. Publicado em: 2009
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6. Influence of elevated CO2 atmosphere, nitric oxida and fungai elicitors on production of phytoalexins in soyobean seedlings / Influencia de atmosfera enriquecida em CO2, do radical oxido nitrico e de eliciadores fungicos na produção de fitoalexinas em plantulas de soja
Soybean seedlings (Glycine max L. Merr) grown in open top chambers under high CO2 concentrations have shown photosynthetic increment and increase in productivity, which in turn may modify the productio n of secondary metabolites with farmacological importance. The aim of this work was to analyze the synthesis of flavones, isoflavones and pterocarpans in soyb
Publicado em: 2007
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7. Propriedades anticÃncer de pterocarpanos naturais / Anticancer properties of naturally occurring pterocarpans
Os pterocarpanos apresentam um nÃcleo tetracÃclico derivado do nÃcleo fundamental das isoflavanonas. O presente trabalho teve como objetivos principais avaliar a atividade antitumoral âin vivoâ de pterocarpanos e realizar estudos de mecanismo de aÃÃo. A avaliaÃÃo da citotoxicidade âin vitroâ mostrou que todas as cÃlulas tumorais tratadas com 2,3,
Publicado em: 2007
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8. Antitumor potential of flavonoids derived from northeastern brazilian plants: preliminary studies on structure-cytotoxic activity relationship / Potencial antitumoral de flavonóides isolados de plantas do nordeste brasileiro: estudos preliminares da relação estrutura-atividade citotóxica
In searching for anticancer compounds derived from plant sources, 18 flavonoids were assayed for their cytotoxic potentials and the results were compared for structure-activity relationship purposes. The flavonoid group was subdivided in flavones and pterocarpans. The cytotoxic activity was initially evaluated on tumor cell lines, through the MTT assay, and
Publicado em: 2005
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9. Estudo fitoquimico de leguminosas : Harleyodendron Unifoliolatum e Holocalyx balansae. Isolamento, determinação estrutural e atividade biologica / Phytochemical analysis of leguminosas : Harleyodendron Unifoliolatum Cowan e Holocalyx Balansae Micheli. Isolation, structural elucidation and biological activities
The phytochemical study of roots extracts from Harleyodendron unifoliolatum and Holocalyx balansae, both belonging to the family Leguminosae, resulted in the isolation of nine isoflavonoids (four pterocarpans, two isoflavans and three isoflavanones) and one phytosteroid being that seven isoflavonoids are now described for the first time. The molecular struct
Publicado em: 2005
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10. Safrol e eugenol: estudo da reatividade química e uso em síntese de produtos naturais biologicamente ativos e seus derivados
The chemical reactivity of safrole, eugenol, piperonal, vanillin and derivates toward ozone, aluminium chloride, brominating agents and butyl lithium was investigated. The synthesis of naturally occuring anthraquinones, furonaphthoquinones, naphthoquinones, lignans and pterocarpans from these easily available staring materials is also discussed.
Química Nova. Publicado em: 2000-06
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11. Nitric Oxide Synthase-Mediated Phytoalexin Accumulation in Soybean Cotyledons in Response to the Diaporthe phaseolorum f. sp. meridionalis Elicitor1
Phytoalexin biosynthesis is part of the defense mechanism of soybean (Glycine max) plants against attack by the fungus Diaporthe phaseolorum f. sp. meridionalis (Dpm), the causal agent of stem canker disease. The treatment of soybean cotyledons with Dpm elicitor or with sodium nitroprusside (SNP), a nitric oxide (NO) donor, resulted in a high accumulation of
American Society of Plant Biologists.