Pulmonary Fibrosis Etiology
Mostrando 1-9 de 9 artigos, teses e dissertações.
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1. Imaging in idiopathic pulmonary fibrosis: diagnosis and mimics
Idiopathic pulmonary fibrosis is a chronic disease of unknown etiology that usually has a progressive course and is commonly associated with a poor prognosis. The main symptoms of idiopathic pulmonary fibrosis, including progressive dyspnea and dry cough, are often nonspecific. Chest high-resolution computed tomography is the primary modality used in the ini
Clinics. Publicado em: 04/02/2019
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2. Quantificação das alterações vasculares pulmonares na fibrose pulmonar idiopática e suas implicações prognósticas / Quantification of pulmonary vascular alterations in Idiopathic pulmonary fibrosis and its prognostic implications
A patogênese da Fibrose Pulmonar Idiopática (FPI/PIU), doença fibroproliferativa crônica, é caracterizada por um processo de reparação anormal com acentuada deposição de matriz extra celular. Neste contexto, a importância das alterações vasculares na evolução da FPI/PIU permanece controversa.O presente estudo objetiva quantificar as alteraçõe
Publicado em: 2007
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3. Tomographic evaluation of the small airways in the interstitial lung diseases / Avaliação tomográfica do acometimento das pequenas vias aéreas nas doenças intersticiais do pulmão
The pathogenesis of idiophatic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial pneumonias, is not completely understood. It is related to a type I pneumocyte injury with loss of basement membrane integrity and failure of normal re-epithelialization and re-endothelialization leading to fibroblast proliferation and extra cellular matr
Publicado em: 2007
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4. New Mechanisms of Pulmonary Fibrosis
The understanding of the pathogenesis of pulmonary fibrosis continues to evolve. The initial hypothetical model suggested chronic inflammation as the cause of pulmonary fibrosis, whereas a subsequent hypothesis posited epithelial injury and impaired wound repair as the etiology of fibrosis without preceding inflammation. Over the past decade, several concept
American College of Chest Physicians.
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5. Idiopathic pulmonary fibrosis: an epithelial/fibroblastic cross-talk disorder
Idiopathic pulmonary fibrosis is a chronic and usually progressive lung disorder of unknown etiology. A growing body of evidence suggests that, in contrast to other interstitial lung diseases, IPF is a distinct entity in which inflammation is a secondary and non-relevant pathogenic partner. Evidence includes the presence of similar mild/moderate inflammation
BioMed Central.
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6. Imatinib mesylate inhibits the profibrogenic activity of TGF-β and prevents bleomycin-mediated lung fibrosis
Idiopathic pulmonary fibrosis is a progressive and fatal fibrotic disease of the lungs with unclear etiology. Prior efforts to treat idiopathic pulmonary fibrosis that focused on anti-inflammatory therapy have not proven to be effective. Recent insight suggests that the pathogenesis is mediated through foci of dysregulated fibroblasts driven by profibrotic c
American Society for Clinical Investigation.
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7. Alveolar Macrophage Dysregulation in Hermansky-Pudlak Syndrome Type 1
Rationale: Individuals with Hermansky-Pudlak syndrome type 1 (HPS-1), an autosomal recessive disorder characterized by defective biogenesis of lysosome-related organelles, develop an accelerated form of progressive fibrotic lung disease. The etiology of pulmonary fibrosis associated with HPS-1 is unknown.
American Thoracic Society.
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8. Increased pulmonary neuroendocrine cells with bombesin-like immunoreactivity in adult patients with eosinophilic granuloma.
Cigarette smoking is associated with hyperplasia of pulmonary neuroendocrine cells and variably increased levels of bombesin-like peptides in the lower respiratory tract. Because the neuropeptide bombesin is a chemoattractant for monocytes and a mitogen for 3T3 fibroblasts, we hypothesized that an excess of neuroendocrine cells and bombesin-like peptides cou
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9. Pleural mesothelial cell transformation into myofibroblasts and haptotactic migration in response to TGF-β1 in vitro
Idiopathic pulmonary fibrosis (IPF) is a disease of unknown etiology characterized by the development of subpleural foci of myofibroblasts that contribute to the exuberant fibrosis noted in the pulmonary parenchyma. Pleural mesothelial cells (PMC) are metabolically dynamic cells that cover the lung and chest wall as a monolayer and are in intimate proximity
American Physiological Society.