Purine Bases
Mostrando 1-12 de 215 artigos, teses e dissertações.
-
1. Characterisation of iunH gene knockout strain from Mycobacterium tuberculosis
BACKGROUND Tuberculosis (TB) is an infectious disease caused mainly by the bacillus Mycobacterium tuberculosis. The better understanding of important metabolic pathways from M. tuberculosis can contribute to the development of novel therapeutic and prophylactic strategies to combat TB. Nucleoside hydrolase (MtIAGU-NH), encoded by iunH gene (Rv3393), is an
Mem. Inst. Oswaldo Cruz. Publicado em: 2017-03
-
2. Geração de ozônio isotopicamente marcado com átomo de oxigênio-18, (18O3), formando oxigênio-18 molecular singlete, 18O2 (1Δg), e modificações na 2\ - desoxiguanosina / Isotopically labeled ozone, 18O3, generate 18O-labeled singlet molecular oxygen, 18O2 (1Δg), and oxidation of product of the purine moiety of 2\ -deoxyguanosine.
O ozônio (O3) é um poderoso oxidante e quantidades significativas podem ser formadas em ambientes urbanos, como resultado de uma série de eventos fotoquímicos, sendo um risco para a saúde humana. Devido a sua reatividade química, o ozônio é capaz de promover modificações oxidativas em diversas biomoléculas, tais como, DNA, proteínas e lipídios.
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/07/2011
-
3. Fração endógena e recuperação urinária de derivados de purinas em novilhas Nelore e Holandesas / Endogenous fraction and urinary recovery of purine derivatives in Nellore and Holstein heifers
Objetivou-se quantificar a contribuição endógena para a excreção urinária de derivados de purinas (DP) e estabelecer a proporção de purinas no abomaso recuperadas na urina, bem como pesquisar possíveis diferenças entre as raças Nelore e Holandesa através da infusão abomasal de RNA (Torula yeast) como fonte de purinas. Utilizaram-se oito novilhas
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/07/2011
-
4. Fração endógena e recuperação urinária de derivados de purinas obtidas por diferentes métodos em bovinos nelore / Endogenous fraction and urinary recovery of purine derivatives obtained through different methods in Nelore cattle
Two experiments were executed utilizing eight Nelore heifers. The first experiment had the following objectives: aimed to evaluate the endogenous fraction at urinary excretion of purine derivatives (DP) in Nelore cattle fed single diet offering different levels of dry matter (MS); to establish the proportion of purines into abomasum recovered from urine and;
Publicado em: 2009
-
5. Efeito dos diferentes níveis de nucleotídeos em frangos de corte alimentados com probióticos / Effect of the different nucleotides levels in broiler chickens fed with probitics
The objective of this experiment was to evaluate the influence of different nucleotides levels in the rations of broilers containing probiotics on response of the birds and its influence on the performance. Birds were allocated in a randomized experimental design with five replications of each treatment. It was used 1,050 chicks of a day of age, males, distr
Publicado em: 2009
-
6. Desempenho e avaliação nutricional de dietas contendo farelo de mamona para bovinos / Performance and nutritional evaluation of diets containing castor meal to cattle
The castor bean (Ricinus communis L.) has been traditionally cultivated in some parts of Brazil with an economic and social role. Thus, because of the high potential of productivity that this culture shows, there is a possibility to increase the use of the castor beans by- products as a protein source in ruminant diets. In order to evaluate the use of castor
Publicado em: 2009
-
7. Rational design of inhibitors of Schistosoma mansoni purine nucleoside phosphorylase / Planejamento racional de inibidores da purina nucleosídeo fosforilase de Schistosoma mansoni
As doenças tropicais têm sido alvo de constantes pesquisas nos últimos anos, em diversos centros em todo o mundo. A procura por novos tratamentos eficazes contra estas desordens estimula a identificação de novos alvos moleculares. A esquistossomose é uma doença parasitária crônica, que afeta cerca de 200 milhões de indivíduos em todo o mundo, caus
Publicado em: 2008
-
8. Nutritional evaluation of sugarcane treated with calcium oxide at different times of exposure to cattle / Avaliação nutricional da cana-de-açúcar acrescida de óxido de cálcio em diferentes tempos de amazenamento para bovinos
Were performed 4 experiments aiming evaluate the chemical composition and in vitro and in situ digestive kinetics of sugarcane treated with calcium oxide at different exposure times under nutrients intake and digestibility, performance, and ruminal parameters of Nellore heifers. The first experiment aimed to evaluate the effects of levels of inclusion and ex
Publicado em: 2008
-
9. Adenylosuccinate Lyase from Leishmania major Friedlin and its role in the purine nucleotides salvage pathway / Adenylosuccinato lyase (ADSL) de leishmania major friedlin: sua relevância na via de recuperação de purino-nucleotídeos
Many species of Leishmania are responsible for serious visceral or skin diseases that exhibit high incidence in tropical and subtropical regions. The drugs currently employed in the treatment of parasitic diseases are potentially carcinogenic, often require prolonged treatment and patient hospitalization. An effective program of drug design requires the vali
Publicado em: 2006
-
10. Purine nucleoside fosforilase from Schistosoma Mansoni: crystal structure, knetics, studies and ligands search / Enzima purina nucleosideo fosforilase de Schistosoma Mansoni: estruturas cristalográficas, estudos cinéticos e descoberta de novos ligantes
O parasita Schistosoma mansoni não possui a via de síntese de bases púricas e depende integralmente da via de salvação de purinas para o seu requerimento de purinas. Uma das enzimas participantes desta via é a Purina Nucleosídeo Fosforilase (PNP) (E.C. 2.4.2.1). A PNP catalisa a fosforólise reversível de nucleosídeos de purina para gerar a base cor
Publicado em: 2003
-
11. Interconversion and uptake of nucleotides, nucleosides, and purine bases by the marine bacterium MB22.
Whole cells and isolated membranes of the marine bacterium MB22 converted nucleotides present in the external medium rapidly into nucleosides and then into bases. Nucleosides and purine bases formed were taken up by distinct transport systems. We found a high-affinity common transport system for adenine, guanine, and hypoxanthine, with a Km of 40 nM. This sy
-
12. Potential of mean force calculations of the stacking-unstacking process in single-stranded deoxyribodinucleoside monophosphates.
The free energy of the stacking-unstacking process of deoxyribodinucleoside monophosphates in aqueous solution has been investigated by potential of mean force calculations along a reaction coordinate, defined by the distance between the glycosidic nitrogen atoms of the bases. The stacking-unstacking process of a ribodinucleoside monophosphate was observed t