Purine Nucleoside
Mostrando 1-12 de 238 artigos, teses e dissertações.
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1. Primary immunodeficiencies: a diagnostic challenge?
Abstract Objectives: The aim of the report is to describe the main immunodeficiencies with syndromic characteristics according to the new classification of Inborn Errors of Immunity. Data source: The data search was centered on the PubMed platform on review studies, meta-analyses, systematic reviews, case reports and a randomized study published in the las
J. Pediatr. (Rio J.). Publicado em: 2021-04
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2. Inborn errors of immunity associated with characteristic phenotypes
Abstract Objectives: The aim of the report is to describe the main immunodeficiencies with syndromic characteristics according to the new classification of Inborn Errors of Immunity. Data source: The data search was centered on the PubMed platform on review studies, meta-analyses, systematic reviews, case reports and a randomized study published in the las
J. Pediatr. (Rio J.). Publicado em: 2021-04
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3. Characterisation of iunH gene knockout strain from Mycobacterium tuberculosis
BACKGROUND Tuberculosis (TB) is an infectious disease caused mainly by the bacillus Mycobacterium tuberculosis. The better understanding of important metabolic pathways from M. tuberculosis can contribute to the development of novel therapeutic and prophylactic strategies to combat TB. Nucleoside hydrolase (MtIAGU-NH), encoded by iunH gene (Rv3393), is an
Mem. Inst. Oswaldo Cruz. Publicado em: 2017-03
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4. Adenosine: an endogenous mediator in the pathogenesis of psoriasis
Abstract: It is known that inflammatory and immune responses protect us from the invasion of micro-organisms and eliminate "wastes" from the injured sites, but they may also be responsible for significant tissue damage. Adenosine, as a purine nucleoside, which is produced in inflamed or injured sites, fulfills its role in limiting tissue damage. Although, it
An. Bras. Dermatol.. Publicado em: 2015-12
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5. Desenvolvimento e aplicação de biorreatores capilares para a triagem de ligantes de Purina Nucleosídeo Fosforilases / Development and application of capillary bioreactors for screening of Purine Nucleoside Phosphorylases ligands
Purine Nucleoside Phosphorylases (PNPs) are key enzymes of the purine salvage pathway, and therefore are considered attractive targets for new drugs search. In this context, the development of effective and selective bioassays for PNP ligands screening is an important task. This work describes the covalent immobilization of human and Schistossoma mansoni PNP
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/02/2012
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6. Estudos estruturais e biofísicos da enzima purina nucleosídeo fosforilase hexamérica de Bacillus subtilis / Structural and biophysical studies of hexameric purin nucleoside phosphorylase of Bacillus subtillis
A enzima purina nucleosídeo fosforilase hexamérica de Bacillus subtilis (BsPNP233) c uma nucleosídeo fosforilase do tipo 1 , responsável pela catalise reversível da reação de guebra de urn nucleosídeo em base nitrogenada e ribose-1-fosfato na via de salvação de purinas. Essa enzima possui interesses biomédicos e biotecnológicos devido ao uso na t
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/08/2011
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7. Descriptor-and fragment-based QSAR models for a series of Schistosoma mansoni purine nucleoside inhibitors
A enzima purina nucleosídeo fosforilase de Schistosoma mansoni (SmPNP) é um alvo molecular atrativo para o tratamento de importantes doenças infecciosas parasitárias, com especial ênfase para o seu papel na descoberta de novos fármacos contra a esquistossomose, uma doença tropical que afeta cerca de 200 milhões de pessoas em 74 áreas endêmicas no m
Journal of the Brazilian Chemical Society. Publicado em: 2011-09
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8. Action of tubercidin a toxic purine analogue in Leishmania spp / Ação do análogo de purina tóxico tubercidina em Leishmania ssp.
Gene identification associated with drug resistance has contributed to a better understanding of the mechanism of action of anti parasitic compounds. Using transfection and over-expression selection strategy we isolated two loci related with the resistance of tubercidin (TUB), a toxic analog purine. In the first locus we identified an ortholog of the TOR gen
Publicado em: 2008
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9. Rational design of inhibitors of Schistosoma mansoni purine nucleoside phosphorylase / Planejamento racional de inibidores da purina nucleosídeo fosforilase de Schistosoma mansoni
As doenças tropicais têm sido alvo de constantes pesquisas nos últimos anos, em diversos centros em todo o mundo. A procura por novos tratamentos eficazes contra estas desordens estimula a identificação de novos alvos moleculares. A esquistossomose é uma doença parasitária crônica, que afeta cerca de 200 milhões de indivíduos em todo o mundo, caus
Publicado em: 2008
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10. Purine nucleoside fosforilase from Schistosoma Mansoni: crystal structure, knetics, studies and ligands search / Enzima purina nucleosideo fosforilase de Schistosoma Mansoni: estruturas cristalográficas, estudos cinéticos e descoberta de novos ligantes
O parasita Schistosoma mansoni não possui a via de síntese de bases púricas e depende integralmente da via de salvação de purinas para o seu requerimento de purinas. Uma das enzimas participantes desta via é a Purina Nucleosídeo Fosforilase (PNP) (E.C. 2.4.2.1). A PNP catalisa a fosforólise reversível de nucleosídeos de purina para gerar a base cor
Publicado em: 2003
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11. Uptake of Nitrobenzylthioinosine and Purine β-l-Nucleosides by Intracellular Toxoplasma gondii
Intracellular Toxoplasma gondii grown in human foreskin fibroblast cells transported nitrobenzylthioinosine {NBMPR; 6-[(4-nitrobenzyl)mercapto]-9-β-d-ribofuranosylpurine}, an inhibitor of nucleoside transport in mammalian cells, as well as the nonphysiological β-l-enantiomers of purine nucleosides, β-l-adenosine, β-l-deoxyadenosine, and β-l-guanosine. T
American Society for Microbiology.
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12. Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors.
Competitive inhibitors of the salvage pathway enzyme purine-nucleoside phosphorylase (purine-nucleoside:orthophosphate ribosyltransferase, EC 2.4.2.1) have been designed by using the three-dimensional structure of the enzyme as determined by x-ray crystallography. The process was an iterative one that utilized interactive computer graphics, Monte Carlo-based