Purines
Mostrando 1-12 de 438 artigos, teses e dissertações.
-
1. Quantification of mitochondrial DNA damage and copy number in circulating blood of patients with systemic sclerosis by a qPCR-based assay,
Abstract Background: Although not fully understood, oxidative stress has been implicated in the pathogenesis of different autoimmune diseases such as systemic sclerosis. Accumulating evidence indicates that oxidative stress can induce mitochondrial DNA (mtDNA) damage and variations in mtDNA copy number (mtDNAcn). Objective: The aim of this study was to exp
An. Bras. Dermatol.. Publicado em: 2020-06
-
2. Estimativa da excreção urinária de derivados de purinas a partir do consumo de NDT e determinação da contribuição endógena em bovinos de corte / Estimation of urinary excretion of purines derivatives from TDN intake and determination of the endogenous contribution in beef cattle
Two experiments were conducted with eight Nelore heifers (BW 267 17 kg ) to assess the excretion of purine derivatives (PD) from intake of TND, the intake and digestibilities of nutrients and the endogenous fraction of PD and nitrogen losses using the technique of fasting. In Exp.I the animal were fed a diet based on corn silage and concentrate in the propor
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/03/2011
-
3. Genotoxicity and mutagenicity of Echinodorus macrophyllus (chapéu-de-couro) extracts
Echinodorus macrophyllus, commonly known as chapéu-de-couro, is a medicinal plant used in folk medicine to treat inflammation and rheumatic diseases. In this work, we used short-term bacterial assays based on the induction of SOS functions to examine the genotoxicity and mutagenicity of an aqueous extract of E. macrophyllus leaves. Whole extract and an ethy
Genetics and Molecular Biology. Publicado em: 02/07/2010
-
4. Ectonucleotidase activities in Sertoli cells from immature rats
Sertoli cells have been shown to be targets for extracellular purines such as ATP and adenosine. These purines evoke responses in Sertoli cells through two subtypes of purinoreceptors, P2Y2 and PA1. The signals to purinoreceptors are usually terminated by the action of ectonucleotidases. To demonstrate these enzymatic activities, we cultured rat Sertoli cell
Publicado em: 2010
-
5. Estudo sobre os mecanismos envolvidos na atividade antinociceptiva das purinas : o papel dos derivados da guanina / Mechanisms involved in the antinociceptive action of purines: the role of guanine-based purines
Os objetivos da presente tese de doutorado foram os de investigar o papel dos derivados da guanina na nocicepção e compreender os mecanismos responsáveis pelos efeitos extracelulares desses compostos. Os resultados desta tese estão divididos em três partes, de acordo com sua natureza, em revisão da literatura (parte um), experimental (parte dois) e cl�
Publicado em: 2009
-
6. Fração endógena e recuperação urinária de derivados de purinas obtidas por diferentes métodos em bovinos nelore / Endogenous fraction and urinary recovery of purine derivatives obtained through different methods in Nelore cattle
Two experiments were executed utilizing eight Nelore heifers. The first experiment had the following objectives: aimed to evaluate the endogenous fraction at urinary excretion of purine derivatives (DP) in Nelore cattle fed single diet offering different levels of dry matter (MS); to establish the proportion of purines into abomasum recovered from urine and;
Publicado em: 2009
-
7. METHODS IN RUMINANT NUTRITION: USE OF FAECAL INDEX TO ESTIMATE INTAKE AND ESTIMATIVE OF RUMEN MICROBIAL PROTEIN SYNTHESIS / MÉTODOS EM NUTRIÇÃO DE RUMINANTES: USO DE ÍNDICES FECAIS PARA ESTIMAR CONSUMO E ESTIMATIVA DA SÍNTESE PROTEICA MICROBIANA RUMINAL
O objetivo deste trabalho foi avaliar métodos em nutrição de ruminantes: o uso de índices fecais para estimar consumo e uso de purinas no duodeno ou de derivados de purinas na urina para estimar a síntese de nitrogênio microbiano ruminal. Foram compilados dados de três ensaios de digestibilidade in vivo utilizando ovinos machos castrados não fistulad
Publicado em: 2009
-
8. Purinergic signalling: past, present and future
The discovery of non-adrenergic, non-cholinergic neurotransmission in the gut and bladder in the early 1960's is described as well as the identification of adenosine 5'-triphosphate (ATP) as a transmitter in these nerves in the early 1970's. The concept of purinergic cotransmission was formulated in 1976 and it is now recognized that ATP is a cotransmitter i
Brazilian Journal of Medical and Biological Research. Publicado em: 03/10/2008
-
9. Ração concentrada à base dos farelos de soja ou de algodão em dietas contendo silagem de milho para fêmeas leiteiras em crescimento / Concentrate ration based on soybean or cottonseed meal in diets containing corn silage for dairy females
The objective of this work was to evaluate concentrate rations based on soybean or cottonseed meal in diets containing corn silage to dairy females, on intake and total apparent digestibility of nutrients, performance, ingestive behavior, diets economic viability, nitrogen balance (NB) and microbial protein production.. There were used 28 crossbred heifers,
Publicado em: 2007
-
10. Molecular characterization of nitrate reductase gene and it expression in the marine red alga Gracilaria tenuistipitata (Rhodophyta) / Aspectos moleculares de nitrato redutase da macroalga marinha Gracilaria tenuistipitata (RHODOPHYTA): seqüenciamento do gene e estudo da expressão do RNA mensageiro
In the marine environment, the major source of nitrogen is nitrate, which must be reduced before incorporation into organic compounds, such as amino acids and nitrogen bases (purines and pyrimidines). The first enzyme that participates in the nitrogen assimilation process is nitrate reductase (NR), which is responsible for the conversion of nitrate to nitrit
Publicado em: 2006
-
11. Activation of a P2Y4-like purinoceptor triggers an increase in cytosolic [Ca2+] in the red blood cells of the lizard Ameiva ameiva (Squamata, Teiidae)
An increasing number of pathophysiological roles for purinoceptors are emerging, some of which have therapeutic potential. Erythrocytes are an important source of purines, which can be released under physiological and physiopathological conditions, acting on purinergic receptors associated with the same cell or with neighboring cells. Few studies have been c
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-01
-
12. Time course evaluation of vascular tonus and superoxide production from isolated purines in aorta of endotoxemics Wistar rats / "Avaliação temporal da regulação do tônus vascular e da produção de superóxido induzido por purinas em aorta isolada de ratos Wistar endotoxêmicos"
Septic patients can evolve for septic shock and 40% of these survive. We characterize the experimental model we evaluate involved factors in the inflammation and evaluate the modulation caused by purines (ATP/ADP) in the superoxide quantification (O2-) and in the vascular reactivity of isolated aorta. The results suggest that in isolated aorta of endotoxemic
Publicado em: 2005