Pyridones
Mostrando 1-5 de 5 artigos, teses e dissertações.
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1. Otimização das condições de cultivo de Beauveria bassiana e Mycoleptodiscus indicus visando à produção de metabólitos com atividades antimicrobiana, antiparasitária e antitumoral / Optimization of culture conditions of Beauveria bassiana and Mycoleptodiscus indicus aiming the production of metabolites with antimicrobial, antitumor and antiparasitic activity
Sabe-se que micro-organismos são vistos como promissoras fontes de moléculas bioativas, incluindo-se nesse grupo fungos endofíticos e também entomopatogênicos. Desse modo, foram selecionados o fungo entompatogênico Beauveria bassiana e o fungo endofítico Mycoleptodiscus indicus. Numa primeira etapa foram prospectadas condições de cultivo favoráveis
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/03/2012
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2. REAÇÕES DE CICLOCONDENSAÇÃO DE CIANOACETOIDRAZIDA COM ENONAS HALOMETIL-SUBSTITUÍDAS / CYCLOCONDENSATION REACTIONS OF CYANOACETOHYDRAZIDE WITH HALOMETHYL-SUBSTITUTED ENONES
The synthesis of thirteen 3-(R1), 4-(R2) and 5-(R3)-substituted 1-cyanoacetyl-5-hydroxy-4,5-dihydro-1H-pyrazoles from the cyclocondensation reaction of 4-alkoxy-3-alken-2-ones [R3C(O)C(R2)=C(R1)(OR), where R3 = CF3, CCl3, CHCl2, CO2Et; R2 = H, Me; R1 = H, Me, Et, Pr, Pentyl, c-Hexyl, Ph, and R = Me, Et] with cyanoacetohydrazide is reported. This reaction was
Publicado em: 2008
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3. Efficacies of ABT-719 and related 2-pyridones, members of a new class of antibacterial agents, against experimental bacterial infections.
The 2-pyridones are a new class of broad-spectrum orally bioavailable antibacterial agents. These compounds are potent bacterial DNA gyrase inhibitors which differ from fluoroquinolones by placement of the nitrogen atom in the ring juncture. ABT-719 is an S isomer and a representative 2-pyridone. ABT-719 administered orally or subcutaneously was 4- to 10-fol
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4. DNA Cleavage Activities of Staphylococcus aureus Gyrase and Topoisomerase IV Stimulated by Quinolones and 2-Pyridones
We have cloned Staphylococcus aureus DNA gyrase and topoisomerase IV and expressed them in Escherichia coli as polyhistidine-tagged proteins to facilitate purification and eliminate contamination by host enzymes. The enzyme preparations had specific activities similar to previously reported values. Potassium glutamate (K-Glu) stimulated the drug-induced DNA
American Society for Microbiology.
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5. In vitro evaluation of ABT-719, a novel DNA gyrase inhibitor.
ABT-719 (A-86719.1) is the first compound of a new class of novel DNA gyrase inhibitors, the 2-pyridones, with potent antibacterial activity against gram-positive, gram-negative, and anaerobic organisms. ABT-719 was more active than ciprofloxacin, sparfloxacin, and clinafloxacin against gram-positive bacteria. ABT-719 was particularly active against Staphylo