Pyrroles
Mostrando 1-12 de 16 artigos, teses e dissertações.
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1. Streamlined Synthesis of 6-((1H-1,2,3-Triazol-4-yl)methyl)-1H-pyrrolo [3,4-d]pyridazin-1-one System via Sequential N-Alkylation, CuAAC, and [4 + 2] Cyclization Reactions
An efficient sequential three-step reaction methodology for the synthesis of three new series-1-(prop-2-yn-1-yl)-1H-pyrroles, methyl 4-acetyl-1-((1H-1,2,3-triazol-4-yl)methyl)-1H-pyrrole-3-carboxylates and 6-((1H-1,2,3-triazol-4-yl)methyl)-2,6-dihydro-1H-pyrrolo[3,4-d]pyridazin-1-ones-is reported. The methodology comprises: (i) N-alkylation reactions of poly
J. Braz. Chem. Soc.. Publicado em: 23/05/2019
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2. Síntese de 3-Trifluoracetil-1H-pirróis N-Aril Substituídos. / Synthesis of N-Aryl Substituted 3-Trifluoracetyl-1H-pyrroles
Este trabalho apresenta uma nova estratégia sintética simples e versátil para a preparação de uma série inédita de 3-trifluoracetil-1H-pirróis N-aril substituídos. Os pirróis foram obtidos a partir da reação do 3-trifluoracetil-4,5-diidrofurano com aril aminas de fórmula geral ArNH2, sendo Ar= C6H4, 2-MeO(C6H4), 3-MeO(C6H4), 4-MeO(C6H4), 2-Me(C6
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/07/2011
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3. Design, synthesis and evaluation of biological derivatives pyrroles potentially antiinflamatory activity / Planejamento, síntese e avaliação biológica de derivados pirrólicos com potencial atividade antiinflamatória
The nonsteroidal antiinflammatory drugs (NSAIDs) are among the most prescribed and used drugs in the world. These drugs inhibit the cyclooxygenases, enzymes responsible for conversion of arachidonic acid into phlogistic prostaglandins, by the action of phospholipase A2. The synthesis of compounds containing pyrrole nucleus in their structures has been a topi
Publicado em: 2009
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4. Indium(III)-catalyzed synthesis of N-substituted pyrroles under solvent-free conditions
Vários pirróis N-substituídos foram sintetizados pela reação de γ-dicetonas (R¹C(O)CH2CH2C(O)R²: R¹, R² = Me, Ph) com aminas (RNH2: R = Alkyl, Aryl, TsNH) ou diaminas (1,6-diaminohexano and 1,2-diaminoetano) na presença de tribrometo de índio, tricloreto de índio ou trifluorometanossulfonato de índio a temperatura ambiente e sem solventes. O pr
Journal of the Brazilian Chemical Society. Publicado em: 2008
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5. Síntese de 3-Trifluoracetilpirróis N-Substituídos / Synthesis of N-Substituted 3-Trifluoroacetyl-Pyrroles
Este trabalho apresenta uma nova estratégia sintética one-pot simples e versátil para a preparação de uma série inédita de 3-trifluoracetilpirróis Nsubstituídos. Os pirróis foram obtidos a partir da reação do 3-trifluoracetil-4,5-dihidrofurano com aminas primárias (RNH2, onde R = H, CH3, CH2CH3, CH(CH3)2, (CH2)2OH, CH2(C5H4N), CH2(C6H5), dentre
Publicado em: 2008
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6. Characterization of squaric acid and derived materials by enhanced Raman spectroscopy (use of high performance metallic SERS substrates) / Caracterização do ácido esquárico e materiais derivados por espectrocopia Raman intensificada (uso de substratos metálicos SERS de alto desempenho)
In this Thesis Surface-Enhanced Raman Scattering (SERS) and resonance Raman spectroscopy were used for monitoring the adsorption and faradaic behavior of squaric acid and its derived species. In addition, the charge transfer salt of squarate and tetrathiofulvalene and the copolymers of squarate and pyrroles were also studied. Another theme developed in this
Publicado em: 2005
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7. Estudo das reações de X diazocetonas com enaminonas. Reatividade e utilidades sinteticas. Novo metodo de sintese de pirrois
The diazodiphenylethanone (1) reacts with the acyclic enaminones 2 to form the products of diphenylketene electrophilic attack on the Ca (3) and/or the nitrogen (4 and 5) position of the enaminone system. The cyclic enaminones 6 showed greater preference for reaction on nitrogen to form products 12 in comparison to Ca reaction products (13). The reactivities
Publicado em: 1988
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8. Reatividade de 2H-azirinas com compostos do grupo do niquel, em solventes aproticos e proticos
The 3-phenyl-2H-azirines 6j-m and the 2-phenyl-3-styryl-2H-azirine, 16z, alI with functional groups bonded to the three-membered ring, were synthesized by the thermolysis of the corresponding vinylazides. We also synthesized the 3,3 -p -phenylene-bis(2H-azirine), 36, which is not described in the literature. A new method to synthesize pyrroles from 2H-azirin
Publicado em: 1981
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9. Extracellular Accumulation of Pyrroles in Bacterial Cultures
Aerobacter aerogenes, Paracolobactrum aerogenoides, Spirillum serpens, and gelatinous strains of Chromobacterium violaceum produced an extracellular, ether-soluble, Ehrlich-positive substance when grown in media prepared with gelatin hydrolysate. The substance has been tentatively identified as pyrrole-2-carboxylic acid. Both hydroxy-l-proline and allo-d-hyd
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10. Cytosine substituted calix[4]pyrroles: Neutral receptors for 5′-guanosine monophosphate
The synthesis and characterization of two cytosine-substituted calix[4]pyrrole conjugates, bearing the appended cytosine attached at either a β- or meso-pyrrolic position, is described. These systems were tested as nucleotide-selective carriers and as active components of nucleotide-sensing ion-selective electrodes at pH 6.6. Studies of carrier selectivity
National Academy of Sciences.
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11. Conformational features of distamycin-DNA and netropsin-DNA complexes by Raman spectroscopy.
The binding of distamycin and netropsin to duplex DNA has been studied by Raman spectroscopy. Several changes occur in the Raman spectra of these drugs upon binding DNA. These changes were analyzed by assigning specific motions to the observed Raman bands through the use of molecular subunits of the drugs and normal mode calculations. Our analysis indicates
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12. Heme axial methionine fluxionality in Hydrogenobacter thermophilus cytochrome c552
The heme group in paramagnetic (S = 1/2) ferricytochromes c typically displays a markedly asymmetric distribution of unpaired electron spin density among the heme pyrrole β substituents. This asymmetry is determined by the orientations of the heme axial ligands, histidine and methionine. One exception to this is ferricytochrome c552 from Hydrogenobacter the
National Academy of Sciences.