Quassinoids
Mostrando 1-10 de 10 artigos, teses e dissertações.
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1. Simaroubaceae family: botany, chemical composition and biological activities
The Simaroubaceae family includes 32 genera and more than 170 species of trees and brushes of pantropical distribution. The main distribution hot spots are located at tropical areas of America, extending to Africa, Madagascar and regions of Australia bathed by the Pacific. This family is characterized by the presence of quassinoids, secondary metabolites res
Rev. bras. farmacogn.. Publicado em: 2014-08
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2. Biological activity of neosergeolide and isobrucein B (and two semi-synthetic derivatives) isolated from the Amazonian medicinal plant Picrolemma sprucei (Simaroubaceae)
In the present study, in vitro techniques were used to investigate a range of biological activities of known natural quassinoids isobrucein B (1) and neosergeolide (2), known semi-synthetic derivative 1,12-diacetylisobrucein B (3), and a new semi-synthetic derivative, 12-acetylneosergeolide (4). These compounds were evaluated for general toxicity toward the
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-02
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3. LC-ESI-MS determination of quassinoids isobrucein B and neosergeolide in Picrolemma sprucei stem infusions
Infusões dos caules de Picrolemma sprucei (pseudônimo: P. pseudocoffea) são principalmente utilizadas como antimaláricos em toda região amazônica. Desta espécie foram isolados os quassinoides isobruceína B e neosergeolida, os quais apresentam atividade antimalárica e citotóxica. Neste estudo, apresentamos o desenvolvimento de uma metodologia analí
Journal of the Brazilian Chemical Society. Publicado em: 2009
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4. Estudo fitoquímico e avaliação do potencial de inibição da enzima acetilcolisnesterase de Simarouba versicolor (SIMAROUBACEAE) / Phytochemical study and evaluate the potential inhibition of the enzyme acetilcolisnesterase Simarouba versicolor (SIMAROUBACEAE)
O presente trabalho descreve o estudo químico e farmacológico da casca do caule da espécie Simarouba versicolor, pertencente á família Simaroubaceae. A espécie ocorre preferencialmente em áreas abertas de solos bem drenados, como cerrados e caatinga. Conhecida popularmente como pau paraíba, mata-cachorro ou simaruba do Brasil, a casca do seu caule po
Publicado em: 2008
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5. Ocorrência e atividade biológica de quassinóides da última década
Quassinoids, the bitter principles of the Simaroubaceae family, are a group of structurally complex and highly oxygenated degraded triterpenes. They are divided into five groups according to their basic skeleton, C-18, C-19, C-20, C-22 and C-25. In recent years, attention has been focused on quassinoids because several of them have shown promising biological
Química Nova. Publicado em: 2007-08
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6. Estudo fitoquímico de Helietta puberula (Rutaceae), Simarouba versicolor (Simaroubaceae) e busca de um processo de microencapsulação de compostos ativos visando o controle de formigas cortadeiras. / PHYTOCHEMICAL INVESTIGATION OF Helietta puberula (RUTACEAE), Simarouba versicolor (SIMAROUBACEAE) AND SEARCH OF MICROENCAPSULATION TECHNICAL OF THE ACTIVES COMPOUNDS FOR THE CONTROL OF LEAF-CUTTING ANTS.
This work involved the bioassay-guided study of Helietta puberula (Rutaceae) e Simarouba versicolor (Simaroubaceae). The biossays were carried out with leaf-cutting ants Atta sexdens rubropilosa, antifungal activity against the symbiotic fungus Leucoagaricus gongylophorus and inhibition of the enzymatic activity of pectinases. The results obtained with extra
Publicado em: 2006
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7. Atividade analgesica e antiulcerogenica de quatro extratos de diferentes polaridades obtidos a partir das cascas de Quassia amara L
Quassia amara L., is a small tree 2-6 m in height, which occur in northern Brazil, Venezuela, Surinam, Colombia, Panamá and Guiana; in Brazil, this species is cultivated from the border with Guiana to the state of Maranhão. The bark wood of this plant is reputed in traditional medicine as having antimicrobial, antianemic and antimalarial activities, as wel
Publicado em: 2001
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8. Plants as sources of antimalarial drugs: in vitro antimalarial activities of some quassinoids.
Fourteen quassinoids, obtained from simaroubaceous plants, were tested for in vitro antimalarial activity. All of these inhibited the incorporation of [3H]hypoxanthine into Plasmodium falciparum in vitro at concentrations below 0.41 microgram ml-1. The two most potent quassinoids, bruceantin and simalikalactone D, showed 50% inhibitory concentration values o
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9. Use of microdilution to assess in vitro antiamoebic activities of Brucea javanica fruits, Simarouba amara stem, and a number of quassinoids.
A microdilution technique for the assessment of in vitro activity against Entamoeba histolytica was devised and validated with metronidazole. The test was used to detect the antiamoebic activities of plant extracts prepared from the traditional remedies Brucea javanica fruits and Simarouba amara stems. The activity was associated with quassinoid-containing f
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10. Bruceantin, a potent amoebicide from a plant, Brucea antidysenterica.
Bruceantin, purified from an Ethiopian plant used to treat dysentery, killed Entamoeba histolytica in vitro (IC50 [the concentration of drug which decreased the number of colonies to half that of controls] = 0.018 microgram/ml). Six related quassinoids of 17 tested were also amoebicidal. No relationship between quassinoid structure and amoebicidal activity w