Quinolines
Mostrando 1-12 de 24 artigos, teses e dissertações.
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1. New Synthetic Quinolines as Cathepsin K Inhibitors
Cathepsin K is a papain-like cysteine protease and is responsible for collagen degradation in bone tissue and thus represents an important target for the development of new therapies for treating diseases such as osteoporosis. Quinolines are an important class of heterocyclic molecular leads with a great pharmacological potential and represent a relevant sca
J. Braz. Chem. Soc.. Publicado em: 2020-08
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2. 2,3,8-Trisubstituted Quinolines with Antimalarial Activity
ABSTRACT Combination therapy drugs are considered a fundamental way to control malaria as it mimimizes the risk of emergence of resistance to the individual partner drugs. Consequently, this type of therapy constitutes a driving force for the discovery of new drugs with different modes of action, since this will provide options for combining different drugs
An. Acad. Bras. Ciênc.. Publicado em: 21/05/2018
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3. Synthesis and Antibacterial Evaluation of 2-Ethyl-1-(4-substituted)phenyl-1 H-imidazole Derivatives as Open-Chain Analogues of 7-Alkoxyl-4,5-dihydro-imidazo[1,2-a]quinolines
A novel series of 2-ethyl-1-(4-substituted)phenyl-1H-imidazole derivatives was designed, synthesized, and tested for its antibacterial activity against various bacterial strains. Most of the synthesized compounds showed potent inhibition of several Gram-positive and Gram-negative bacterial strains with minimum inhibitory concentration (MIC) values in the ran
J. Braz. Chem. Soc.. Publicado em: 2018-04
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4. SÍNTESE DE 2-(2-PIRIDIL)QUINOLINAS PROMOVIDA POR MICRO-ONDAS E SUAS ATIVIDADES ANTIFÚNGICAS
In this work a series of 2-(2- pyridyl)quinolines were prepared via a Povarov reaction between anilines, 2-pyridinocarbadehyde and ethyl vinyl ether under microwaves heating conditions. The optimized conditions herein reported allowed the preparation of several pyridylquinolines in yields in the range of 30-83%, some of them not previously accessible by this
Quím. Nova. Publicado em: 2017-09
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5. Antioxidant effect of quinoline derivatives containing or not selenium: Relationship with antinociceptive action quinolines are antioxidant and antinociceptive
ABSTRACT The present study investigated the antioxidant effect of a new class of quinoline derivatives (a-d) on assays in vitro. Lipid peroxidation, thiol peroxidase-like and free radical scavenging activities were determined to evaluate antioxidant activity of compounds. Thiol oxidase-like and δ-aminolevulinate dehydratase activities were performed as a to
An. Acad. Bras. Ciênc.. Publicado em: 22/05/2017
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6. Quinolines by Three-Component Reaction: Synthesis and Photophysical Studies
The synthesis of five quinolines 8-octyloxy-4-[4-(octyloxy)phenyl]quinoline and 6-alkoxy- 2-(4-alkoxyphenyl)-4-[(4-octyloxy)aryl]quinolines are described by three-component coupling reaction mediated by Lewis acid FeCl3 and Yb(OTf)3. 4-n-octyloxybenzaldehyde, anisaldehyde, 4-n-octyloxyaniline p-anisidine, and 1-ethynyl-4-heptyloxybenzene, 1-ethynyl-4-octylox
J. Braz. Chem. Soc.. Publicado em: 2015-03
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7. Synthesis of novel quinolines using TsOH/ionic liquid under microwave
Neste trabalho, 3-haloacetil-4-metilquinolinas foram sintetizadas a partir da reação de 4-alcóxi-3-alquen-2-onas [R¹C(O)CH=C(R²)OCH3, onde R¹ = CF3, CCl3, CHCl2, CF2Cl e CF2CF3 e R² = Me, Et, Pr, Bu, i-Bu e i-Pe] e 2-aminoacetofenona. A reação foi realizada em líquido iônico e ácido 4-toluenosolfônico sob irradiação de micro-ondas. Os resultad
J. Braz. Chem. Soc.. Publicado em: 11/09/2012
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8. Simultaneous regioselective synthesis of trifluoromethyl-containing 1,7-phenanthrolines and quinolines from cyclocondensation reaction of N,N'-bis(oxotrifluoroalkenyl)-1,3-phenylenediamines
Este trabalho relata interessantes resultados relativos a síntese convencional de uma nova série de 2,10-dialquil(aril)-4,8-bis (trifluorometil)-1,7-fenantrolinas, em rendimentos de 22-40%, a partir das reações de ciclização de N,N'-bis(oxotrifluoralquenil)-1,3-fenilenodiaminas [1,3-C6H4-(NHCR=CHC(O)CF3)2] em um meio fortemente ácido (PPA) e na ausên
Journal of the Brazilian Chemical Society. Publicado em: 2011-08
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9. Síntese e Avaliação Biológica de Derivados Cíclicos de Tiopurina e de Derivados de Quinolinas Conjugados com Ácido Cólico Via Click Chemistry
This dissertation entitled Synthesis and Biological Evaluation of Cyclical Derivatives of Thiopurine and Quinolines Derivatives Conjugated with Cholic Acid via Click Chemistry was divided in two chapters that describe the synthesis of compounds with potential anti-parasitic activity. The first chapter describes the synthesis of 6-mercaptopurine (6-MP) deriva
Publicado em: 2009
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10. Quinoleínas substutuídas na posição 2 com potencial leishmanicida : seleção de um composto promissor para o desenvolvimento clínico
Um estudo etnofarmacológico realizado com as plantas tradicionalmente usadas na Bolívia para curar lesões da leishmaniose cutânea conduziu à descoberta da espécie Galipea longiflora . As purificações bioguiadas a partir da casca do caule, da casca da raiz e das folhas do arbusto conduziram ao isolamento de uma nova família de alcalóides, as quinole
Publicado em: 2008
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11. Propriedades fotoquímicas e fotofísicas de novos materiais derivados quinolinas e di naftalimidas / Photochemistry and photophysical properties of new materials derivatives of quinolines and Di-naphtalimides
Excited state proto transfer reactions in aqueous media is among current themes in photochemistry research. Shortly, organic molecules having acid or basic groups and presenting excited state lifetimes long enough, competitive prototropic reactions can occur. This phenomenon is attributed to an isoelectronic state of the ground state molecule and up to seven
Publicado em: 2007
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12. Hydroxylation and biodegradation of 6-methylquinoline by pseudomonads in aqueous and nonaqueous immobilized-cell bioreactors.
Selective culturing of pseudomonads that could degrade quinoline led to enrichment cultures and pure cultures with expanded substrate utilization and transformation capabilities for substituted quinolines in immobilized and batch cultures. Immobilized cells of the pseudomonad cultures rapidly transformed quinolines to hydroxyquinolines in bioreactors and wer