Quinone
Mostrando 1-12 de 460 artigos, teses e dissertações.
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1. ESTUDO TEÓRICO E EXPERIMENTAL DE ESTRUTURA E REATIVIDADE RELACIONADO AO METABOLISMO E TOXICIDADE DO PARACETAMOL
An experimental and theoretical approach on oxidative metabolism of paracetamol was applied for the pharmaceutical chemistry learning. Classical reactions, functional group identification, structural parameter, and chemical reactivity using frontier orbitals and Fukui index were used explaining the main products between N-acetyl-p-benzosemiquinone (NAPQI) an
Química Nova. Publicado em: 2022
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2. Effects of Polycyclic Aromatic Hydrocarbon Pendant-Armed Ligands on the Catecholase Activity of Dinuclear Copper(II) Complexes
Herein, we present three new binuclear copper(II) complexes containing different polycyclic aromatic hydrocarbons, able to catalyze the oxidation of 3,5-di-tert-butylcathecol, a model substrate for catechol oxidase. The ligands and complexes were successful characterized in solid and solution states. The structure of C1 was determined by X-ray crystallograph
J. Braz. Chem. Soc.. Publicado em: 2021-05
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3. Synthesis and Biological Evaluation of Benzo[f]indole-4,9-diones N-Linked to Carbohydrate Chains as New Type of Antitumor Agents
In this work, we report the synthesis of three series of carbohydrate-based benzo[f]indole-4,9-diones and amino-1,4-naphthoquinone derivatives and evaluated their cytotoxic activity against eight human cancer cell lines. Several compounds showed a promising cytotoxic activity toward the tumor cell lines (half maximal inhibitory concentration (IC50) < 10.0 μ
J. Braz. Chem. Soc.. Publicado em: 2021-03
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4. Medicinal Electrochemistry of Halogenated and Nitrated Pterocarpanquinones
Electrochemical methods are considered useful tools for simulations of biological redox reactions. The activities of quinones depend on their bioreduction. Biologically active pterocarpanquinones LQB-149 (nitroderivative), 150 and 151 (bromo and chloroderivatives, respectively) were electrochemically investigated by cyclic voltammetry, differential pulse vol
J. Braz. Chem. Soc.. Publicado em: 24/10/2019
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5. Nrf2, NF-κB and PPARβ/δ mRNA Expression Profile in Patients with Coronary Artery Disease
Resumo Fundamentos: O estresse oxidativo e a inflamação estão presentes na doença arterial coronariana (DAC) e estão ligados à ativação do fator de transcrição nuclear kappa B (NF-κB). Para atenuar essas complicações, fatores de transcrição como o fator nuclear eritroide 2-relacionado ao fator 2 (Nrf2) e o receptor ativado por proliferador de
Arq. Bras. Cardiol.. Publicado em: 18/07/2019
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6. The compound, diallyl disulfide, enriched in garlic, prevents the progression of doxorubicin-induced nephropathy
Abstract The main medicinal property of garlic is mostly attributed to its organosulfur compounds, of which the oil-soluble diallyl disulfide (DADS) is the principal component of distilled garlic oil. Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important cellular regulator in response to oxidative stress. This study assessed the possible protect
Food Sci. Technol. Publicado em: 27/05/2019
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7. Clinical Trials in Mitochondrial Disease: An Update on EPI-743 and RP103
Abstract Mitochondrial dysfunction results in the production of an abnormally high amount of reactive oxygen and nitrogen species, which results in redox imbalance and glutathione deficiency. Therapeutics such as EPI-743 (?-tocotrienol quinone) and RP103 (cysteamine bitartrate) have the theoretical potential to improve redox imbalance by increasing intracell
J. inborn errors metab. screen.. Publicado em: 16/05/2019
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8. Relationship between Electrochemical Parameters, Cytotoxicity Data against Cancer Cells of 3-Thio-Substituted Nor-Beta-Lapachone Derivatives. Implications for Cancer Therapy
Electrochemical methods are powerful in the characterization and design of redox-modulating agents. We, herein, report the electrochemical investigation, in aprotic medium, of eleven synthetic 3-thio-substituted-nor-beta-lapachones, along with the determination of cytotoxic activity and correspondent selectivity index, against several cancer cell lines and o
J. Braz. Chem. Soc.. Publicado em: 2019-03
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9. Comparison of the efficacy of QoI fungicides, alone or in mixture with triazoles, in Asian soybean rust control, 2016/17 growing season
RESUMO Tem sido relatada a evolução da redução da sensibilidade de Phakopsora pachyrhizi às misturas dos três mecanismos de ação sítio-específicos (IDMs, IQes e ISDHs) usadas no seu controle. O objetivo desse trabalho foi quantificar a contribuição atual dos IQes, isolados ou em mistura com triazpois, no controle da ferrugem asiática da soja. Em
Summa phytopathol.. Publicado em: 2019-03
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10. Grafting of Quinones on Carbons as Active Electrode Materials in Electrochemical Capacitors
The electrochemical performance of electrochemical capacitors can be improved with electroactive quinone molecules. Systems based on redox active electrolyte as well as physisorbed and chemically grafted molecules have been investigated. In all these cases, carbon materials were used as substrate and electrode material. This short review will mainly describe
J. Braz. Chem. Soc.. Publicado em: 2018-05
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11. Mass Spectrometry Analysis of Protonated Marine Natural Product Seriniquinone
Seriniquinone is a natural quinone isolated from a rare marine bacterium of the genus Serinicoccus. This secondary metabolite has been shown to have anticancer properties, which has raised attention of the scientific community. In this short report, we present the first investigation of the gas-phase chemistry fragmentation reactions of seriniquinone in elec
J. Braz. Chem. Soc.. Publicado em: 2018-05
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12. An overview of odoriferous marine seaweeds of the Dictyopteris genus: insights into their chemical diversity, biological potential and ecological roles
ABSTRACT Since the middle of the twentieth century the marine algae have attracted attention as a source of new drugs. Dictyopteris is an important group of marine seaweeds and is widely distributed in tropical, subtropical and temperate regions. This genus is known by its characteristic “ocean smell”. Some species show a distinct phytochemistry, with sp
Rev. bras. farmacogn.. Publicado em: 2018-04