Quinpirole
Mostrando 1-12 de 33 artigos, teses e dissertações.
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1. Envolvimento de mecanismos dopaminérgicos na expressão do medo condicionado contextual em ratos / Involvement of dopaminergic mechanisms in the expression of contextual conditioned fear in rats
É reconhecido que as experiências que geram reações de medo são praticamente indeléveis do encéfalo dos organismos e que condicionamentos aversivos suscitam inúmeras respostas defensivas, como o congelamento, sendo esta resposta um indicador de medo em roedores. Vários trabalhos têm apontado para a relação entre alterações na transmissão dopam
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/04/2012
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2. Mecanismos dopaminérgicos na aquisição e expressão do medo condicionado: envolvimento de receptores D1 e D2 / Dopaminergic mechanisms in the acquisition and expression of conditioned fear: involviment of D1 and D2 receptors
The increase in the startle reflex in the presence of a stimulus that has been previously paired to footshock is taken as an index of fear and named fear potentiated startle (FPS). Freezing behavior, a cessation of all observable movements, except those associated with respiration, has also been used as an index of fear in rats. A growing body of evidence ha
Publicado em: 2006
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3. Dopamine actions on calcium currents, potassium currents and hormone release in rat melanotrophs.
1. Intracellular and whole-cell recordings were made from primary cultures of rat intermediate pituitary cells; beta-endorphin secretion was also measured by radioimmunoassay. The effects of dopamine receptor activation on hormone secretion, calcium currents and resting potassium conductance were compared. 2. Spontaneous sodium-dependent action potentials oc
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4. Circadian modulation of dopamine receptor responsiveness in Drosophila melanogaster
We investigated the circadian function of Drosophila dopamine receptors by using a behaviorally active decapitated preparation that allows for direct application of drugs to the nerve cord. Quinpirole, a D2-like dopamine receptor agonist, induces reflexive locomotion in decapitated flies. We show that the amount of locomotion induced changes as a function of
The National Academy of Sciences.
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5. Dopamine (D2) receptor regulation of intracellular calcium and membrane capacitance changes in rat melanotrophs.
1. Indo-1 microfluorimetry and patch clamp techniques were used to study the decrease in cytosolic [Ca2+] ([Ca2+]i) caused by dopamine (D2) receptor activation and the calcium dependence of membrane capacitance changes in single rat melanotrophs. 2. [Ca2+]i decreased when extracellular calcium was removed or when the calcium channel blockers nickel (2 mM) or
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6. Distinct roles of dopamine D2L and D2S receptor isoforms in the regulation of protein phosphorylation at presynaptic and postsynaptic sites
Dopamine D2 receptors are highly expressed in the dorsal striatum where they participate in the regulation of (i) tyrosine hydroxylase (TH), in nigrostriatal nerve terminals, and (ii) the dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32), in medium spiny neurons. Two isoforms of the D2 receptor are generated by differential splicing of the sam
The National Academy of Sciences.
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7. Systemic blockade of D2-like dopamine receptors facilitates extinction of conditioned fear in mice
Extinction of conditioned fear in animals is the explicit model of behavior therapy for human anxiety disorders, including panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder. Based on previous data indicating that fear extinction in rats is blocked by quinpirole, an agonist of dopamine D2 receptors, we hypothesized that blockad
Cold Spring Harbor Laboratory Press.
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8. Compulsive checking behavior of quinpirole-sensitized rats as an animal model of Obsessive-Compulsive Disorder(OCD): form and control
BioMed Central.
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9. D2 dopamine receptors induce mitogen-activated protein kinase and cAMP response element-binding protein phosphorylation in neurons
Dopamine, by activating D1- and D2-class receptors, plays a significant role in regulating gene expression. Although much is known about D1 receptor-regulated gene expression, there has been far less information on gene regulation mediated by D2 receptors. In this study, we show that D2 receptors can activate the mitogen-activated protein kinase (MAPK) and t
The National Academy of Sciences.
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10. Single K+ channels activated by D2 dopamine receptors in acutely dissociated neurons from rat corpus striatum.
Corpus striatum neurons acutely dissociated from the brains of young adult rats had membrane surfaces suitable for G omega-seal recording. Whole-cell current-clamp and voltage-clamp recordings indicated that the cells remained electrically excitable after dissociation. Cell-attached recordings frequently revealed single-channel openings in the presence of do
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11. Morphogenic potentials of D2, D3, and D4 dopamine receptors revealed in transfected neuronal cell lines.
Molecular cloning studies have defined a family of dopamine D2-like receptors (D2, D3, and D4), which are the products of separate genes. Our previous work has shown that stimulation of dopamine D2-like receptors in cultures of fetal cortical neurons increases the extension and branching of neurites. To determine which D2-like receptors possess morphogenic p
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12. Dopamine acts on D2 receptors to increase potassium conductance in neurones of the rat substantia nigra zona compacta.
1. Intracellular recordings were made from neurones in the substantia nigra zona compacta in slices of rat mesencephalon in vitro. The majority of neurones fired action potentials spontaneously at 0.2-5.6 Hz. Dopamine, applied either by superfusion or from the tip of a pressurized pipette, prevented spontaneous action potential firing and hyperpolarized the