Rad9 Rad1 Hus1
Mostrando 1-12 de 32 artigos, teses e dissertações.
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1. Caracterização do gene LmHUS1 e de sua participação no fenômeno de amplificação gênica em Leishmania spp. / LmHUS1 gene characterization and its participation in the gene amplification in Leishmania spp.
The protozoan parasite Leishmania presents a dynamic and plastic genome in which gene amplification and chromosome translocations are common phenomena. Such plasticity hints at the necessity of dependable genome maintenance pathways. Eukaryotic cells have evolved checkpoint control systems that recognize altered DNA structures and halt cell cycle progression
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/09/2011
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2. Funções da proteína Pso9/Mec3 no controle do ciclo celular e reparação de DNA em Saccharomyces cerevisiae
A manutenção da estabilidade do material hereditário das células requer fidelidade na replicação do DNA, precisão na segregação dos cromossomos e a capacidade de evitar mutações herdáveis, causadas por injúrias espontâneas e induzidas no genoma. Para enfrentar estes desafios, as células possuem processos evolutivamente conservados, incluindo r
Publicado em: 2007
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3. Oxidative damage-related genes expression profile evaluation in patients with Alzheimers disease / Avaliação da expressão de genes processadores de danos oxidativos em pacientes com Alzheimer
Uma parcela significativa das lesões na molécula do DNA é causada por espécies reativas de oxigênio e a sua produção excessiva e/ou o funcionamento deficiente dos sistemas celulares antioxidantes, que neutralizam a sua ação, é conhecido como estresse oxidativo. Os danos em células normais são prontamente detectados por um sistema de defesa e, em
Publicado em: 2007
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4. Characterization of Schizosaccharomyces pombe Hus1: a PCNA-Related Protein That Associates with Rad1 and Rad9
Hus1 is one of six checkpoint Rad proteins required for all Schizosaccharomyces pombe DNA integrity checkpoints. MYC-tagged Hus1 reveals four discrete forms. The main form, Hus1-B, participates in a protein complex with Rad9 and Rad1, consistent with reports that Rad1-Hus1 immunoprecipitation is dependent on the rad9+ locus. A small proportion of Hus1-B is i
American Society for Microbiology.
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5. Structure-Function Analysis of Fission Yeast Hus1-Rad1-Rad9 Checkpoint Complex
Hus1, Rad1, and Rad9 are three evolutionarily conserved proteins required for checkpoint control in fission yeast. These proteins are known to form a stable complex in vivo. Recently, computational studies have predicted structural similarity between the individual proteins of Hus1-Rad1-Rad9 complex and the replication processivity factor proliferating cell
The American Society for Cell Biology.
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6. The human checkpoint sensor and alternative DNA clamp Rad9–Rad1–Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery
The human checkpoint sensor and alternative clamp Rad9–Rad1–Hus1 can interact with and specifically stimulate DNA ligase I. The very recently described interactions of Rad9–Rad1–Hus1 with MutY DNA glycosylase, DNA polymerase β and Flap endonuclease 1 now complete our view that the long-patch base excision machinery is an important target of the Rad9
Portland Press Ltd..
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7. The Human G2 Checkpoint Control Protein hRAD9 Is a Nuclear Phosphoprotein That Forms Complexes with hRAD1 and hHUS1
Eukaryotic cells actively block entry into mitosis in the presence of DNA damage or incompletely replicated DNA. This response is mediated by signal transduction cascades called cell cycle checkpoints. We show here that the human checkpoint control protein hRAD9 physically associates with two other checkpoint control proteins, hRAD1 and hHUS1. Furthermo
The American Society for Cell Biology.
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8. Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes
The repair of damaged DNA is coupled to the completion of DNA replication by several cell cycle checkpoint proteins, including, for example, in fission yeast Rad1Sp, Hus1Sp, Rad9Sp and Rad17Sp. We have found that these four proteins are conserved with protein sequences throughout eukaryotic evolution. Using computational techniques, including fold recognitio
Oxford University Press.
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9. Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin
Cells respond to DNA damage by activating a network of signaling pathways that control cell cycle progression and DNA repair. Genetic studies in yeast suggested that several checkpoint proteins, including the RFC-related Rad17 protein, and the PCNA-related Rad1–Rad9–Hus1 protein complex might function as sensors of DNA damage. In this study, we show that
Cold Spring Harbor Laboratory Press.
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10. Protein kinase Cδ is responsible for constitutive and DNA damage-induced phosphorylation of Rad9
The mammalian homolog of the Schizosaccharomyces pombe Rad9 is involved in checkpoint signaling and the induction of apoptosis. While the mechanisms responsible for the regulation of human Rad9 (hRad9) are not known, hRad9 is subject to hyperphosphorylation in the response of cells to DNA damage. The present results demonstrate that protein kinase Cδ (PKC�
Oxford University Press.
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11. Replication protein A-mediated recruitment and activation of Rad17 complexes
The human Rad17–Rfc2-5 and Rad9–Rad1–Hus1 complexes play crucial roles in the activation of the ATR-mediated DNA damage and DNA replication stress response pathways. In response to DNA damage, Rad9 is recruited to chromatin in a Rad17-dependent manner in human cells. However, the DNA structures recognized by the Rad17–Rfc2-5 complex during the damage
National Academy of Sciences.
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12. Structure and Functional Implications of the Human Rad9-Hus1-Rad1 Cell Cycle Checkpoint Complex*
Cellular DNA lesions are efficiently countered by DNA repair in conjunction with delays in cell cycle progression. Previous studies have demonstrated that Rad9, Hus1, and Rad1 can form a heterotrimeric complex (the 9-1-1 complex) that plays dual roles in cell cycle checkpoint activation and DNA repair in eukaryotic cells. Although the 9-1-1 complex has been
American Society for Biochemistry and Molecular Biology.