Rank Ligand
Mostrando 1-12 de 47 artigos, teses e dissertações.
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1. Gliclazide reduced oxidative stress, inflammation, and bone loss in an experimental periodontal disease model
Abstract Objective The aim of this study was to evaluate the effects of gliclazide on oxidative stress, inflammation, and bone loss in an experimental periodontal disease model. Material and Methods Male albino Wistar rats were divided into no ligature, ligature, and ligature with 1, 5, and 10 mg/kg gliclazide groups. Maxillae were fixed and scanned usin
J. Appl. Oral Sci.. Publicado em: 21/02/2019
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2. Alveolar bone healing in rats: micro-CT, immunohistochemical and molecular analysis
Abstract Alveolar bone healing after upper incisor extraction in rats is a classical model of preclinical studies. The underlying morphometric, cellular and molecular mechanism, however, remains imprecise in a unique study. Objectives The aim of this study was therefore to characterize the alveolar bone healing after upper incisor extraction in rats by mic
J. Appl. Oral Sci.. Publicado em: 18/06/2018
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3. Rankl expression predicts poor prognosis in gastric cancer patients: results from a retrospective and single-center analysis
The receptor activator of nuclear factor κB ligand (RANKL)/RANK pathway plays an important role in the prognosis of several solid tumor types, but its role in gastric cancer prognosis has been poorly characterized. A total of 116 gastric cancer patients who underwent surgical resection were enrolled in this study. Expressions of RANKL and RANK in gastric ca
Braz J Med Biol Res. Publicado em: 11/01/2018
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4. The effects of chitosan oligosaccharides on OPG and RANKL expression in a rat osteoarthritis model
Abstract Purpose: To investigate the effect of chitosan oligosaccharides (COS) against osteoarthritis (OA) and preliminarily discuss the osteoprotegerin (OPG), receptor activator of NF-κB ligand (RANKL) and RANK expression in a rat OA model. Methods: Thirty-six 6-week-old Male SD rats were randomly divided into three groups: sham-operated group(CON), OA-i
Acta Cir. Bras.. Publicado em: 2017-06
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5. Planejamento de inibidores baseado em fragmentos moleculares para a enzima gliceraldeído-3-fosfato desidrogenase de Trypanosoma cruzi / Design of inhibitors through fragment-based drug discovery for the enzyme glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi
Chagas disease is a parasitic illness endemic in Latin America caused by the trypanosomatid parasite Trypanosoma cruzi that spreads around the world due to people migration. Nowadays, Benznidazole and Nifurtimox (banned in Brazil), are used for the treatment of this disease but causes severe side effects to patients. Recently, three new molecules have reache
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/04/2012
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6. Perfil Local de citocinas e tratamento de bolsas residuaisem diabéticos tipo 2 com periodontite crônica. / Local profile of cytokines and treatment of waste bags in diabetics type 2 with chronic periodontitis.
Objetivo: Esse trabalho foi composto por dois estudos científicos cujos objetivos foram: Estudo1 Comparar os níveis locais de citocinas (INF-, TNF-, IL-17, IL-23 e IL-4), RANKL e OPG em indivíduos com periodontite crônica sistemicamente saudáveis e portadores de diabetes melito tipo 2 bem controlados e com controle glicêmico insatisfatório. Estudo 2 A
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/03/2011
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7. Levels of Ligand receptor activator nuclear factor kb (RANKL) and Osteoprotegerin (OPG) in fluid peri-implant crevicular implants charged immediately in patients with osteopenia / Níveis do ligante receptor ativador do fator nuclear kb (Rankl) e osteoprotegerina (OPG) no fluido crevicular peri-implantar de implantes carregados imediatamente em pacientes com osteopenia
The successful outcome of immediately loaded implants is influenced by a number of confounding factors, such as bone remodeling response and bone quality in the periimplant site. Bone resorption is controlled by the interaction of the receptor activator of the NF-kß ligand (RANKL) and osteoprotegerin (OPG). RANKL induces osteoclast formation and activation
Publicado em: 2011
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8. Expressão de reguladores da reabsorção óssea (RANK/RANKL/OPG) e formação óssea (osteocalcina) em lesões realcionadas ao osso e osteossarcoma / Markers of bone remodeling in neoplastic and bone-related lesions
O sistema RANK (receptor activator of nuclear factor Kappa-Beta)-RANKL (receptor activator of nuclear factor-kappa beta ligand)-OPG (osteoprotegerin) constitui uma das principais vias de diferenciação e ativação dos osteoclastos e alterações nessa via tem sido associadas a diversas lesões relacionadas ao osso (LRO), benignas e maligna como no osteossa
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/03/2010
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9. Expressão de reguladores da reabsorção óssea (RANK/RANKL/OPG) e formação óssea (osteocalcina) em lesões realcionadas ao osso e osteossarcoma / Markers of bone remodeling in neoplastic and bone-related lesions
The RANK (receptor activator of nuclear factor Kappa-Beta)-RANKL (receptor activator of nuclear factor-kappa beta ligand)-OPG (osteoprotegerin) system is the principal means of differentiating and activating osteoclasts. Changes along this path have been associated with various bone related lesions (BRL), whether benign or malignant, such as osteosarcoma (OS
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/03/2010
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10. Exprassão imuno-histoquímica dos fatores de reabsorção óssea em lesões centrais e periféricas de células gigantes
The Giant Cell Lesions, both the Central Giant Cells Lesions (CGCL) as the Peripheral Giant Cells Lesions (PGCL), correspond to a group of oral lesions that are histologically similar entities; however they show a variable clinical behaviour. The purpose of this study was to compare the immunohistochemical expression of bone resorption factors RANK (Receptor
Publicado em: 2010
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11. RANK, RANKL and osteoprotegerin in arthritic bone loss
Rheumatoid arthritis is characterized by the presence of inflammatory synovitis and destruction of joint cartilage and bone. Tissue proteinases released by synovia, chondrocytes and pannus can cause cartilage destruction and cytokine-activated osteoclasts have been implicated in bone erosions. Rheumatoid arthritis synovial tissues produce a variety of cytoki
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-02
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12. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
A receptor that mediates osteoprotegerin ligand (OPGL)-induced osteoclast differentiation and activation has been identified via genomic analysis of a primary osteoclast precursor cell cDNA library and is identical to the tumor necrosis factor receptor (TNFR) family member RANK. The RANK mRNA was highly expressed by isolated bone marrow-derived osteoclast pr
The National Academy of Sciences.