Rats Zucker
Mostrando 1-12 de 59 artigos, teses e dissertações.
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1. The influence of sleep deprivation and obesity on DNA damage in female Zucker rats
OBJECTIVE: The aim of this study was to evaluate overall genetic damage induced by total sleep deprivation in obese, female Zucker rats of differing ages. METHOD: Lean and obese Zucker rats at 3, 6, and 15 months old were randomly distributed into two groups for each age group: home-cage control and sleep-deprived (N = 5/group). The sleep-deprived groups wer
Clinics. Publicado em: 2013
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2. Effects of sleep deprivation in cardiovascular parameters in male and female rats. / Efeitos da privação de sono sobre parâmetros cardiovasculares em ratos machos e fêmeas
A redução no tempo de sono caracteriza a sociedade moderna. A associação recíproca entre a duração do sono e o ganho de peso tem sido atualmente explorada. Contudo, as conseqüências desses fatores no sistema cardiovascular permanecem não completamente elucidadas, principalmente quando verificadas ao longo da vida. Além disso, as conseqüências da
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/06/2011
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3. Caracterização química e influência da bebida do café na síndrome metabólica e estresse oxidativo em ratos Zucker diabéticos / Chemical characterization and influence of the coffee drink on metabolic syndrome and oxidative stress in diabetic Zucker rats
This study aimed to evaluate the antioxidant activity of coffee soft drink in three different degrees of roasting, in vitro and in vivo and the effect of that drink in Zucker diabetic rats with metabolic syndrome. In all experiments, the beverage was prepared under the same methodology. Were determined the contents of the aqueous extract, ash, soluble solids
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/07/2010
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4. Quantitative evaluation of experimental choroidal neovascularization by confocal scanning laser ophthalmoscopy: fluorescein angiogram parallels heparan sulfate proteoglycan expression
The objective of the present study was to develop a quantitative method to evaluate laser-induced choroidal neovascularization (CNV) in a rat model using Heidelberg Retina Angiograph 2 (HRA2) imaging. The expression of two heparan sulfate proteoglycans (HSPG) related to inflammation and angiogenesis was also investigated. CNV lesions were induced with argon
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-07
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5. Efeitos do treinamento físico aeróbio sobre o sistema renina angiotensina cardíaco e sistêmico de ratos obesos / Effects of aerobic exercise training on cardiac and systemic renin- angiotensin system in obese rats
Introdução: A obesidade bem como um aumento da ativação do sistema renina angiotensina cardíaco estão profundamente envolvidos com o desenvolvimento de doenças cardiovasculares. Por outro lado, o treinamento físico aeróbio, previne o desenvolvimento da obesidade e reduz o sistema renina angiotensina cardíaco em algumas patologias. Dessa forma, noss
Publicado em: 2010
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6. Morphological, biomechanical and biochemical analysis of tendon of obese Zucker (fa/fa) rats / Analise morfologica, biomecanica e bioquimica de tendão de ratos Zucker (fa/fa) obesos
Obesity is considered a worldwide epidemic, one of the biggest public health problems in many parts of the planet, which grows in alarming rates. In Brazil, the decline in rates of malnutrition has been accompanied by rising rates of overweight and obesity, which can be defined as the accumulation of abnormal or excessive fat which presents a risk to health.
Publicado em: 2009
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7. Inter-relação entre as vias de transmissão do sinal de insulina e leptina em hipotalamo e figado de ratos
Insulin and leptin have overlapping effects in the control of energy homeostasis and glucose metabolism, but the molecular basis of this synergism is unknown. Insulin signals through a receptor tyrosine kinase that phosphorylates and activates the docking proteins IRSs (insulin receptor substrates), whereas the leptin receptor and its associated protein tyro
Publicado em: 2002
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8. Potassium channel dysfunction in hypothalamic glucose-receptive neurones of obese Zucker rats.
1. We have shown, using intracellular and cell-attached recordings, that glucose-receptive (GR) neurones of obese Zucker rats exhibit abnormal electrophysiological responses to changes in extracellular glucose concentration, whereas GR neurones of lean Zucker and control rats respond normally. 2. In inside-out recordings from obese rat GR neurones it was sho
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9. Divergent regulation of the Glut 1 and Glut 4 glucose transporters in isolated adipocytes from Zucker rats.
We have studied the relationship between glucose uptake rate and Glut 1 and Glut 4 protein and mRNA levels per fat cell in lean (FA/FA) and obese (fa/fa) Zucker rats at 5, 10, and 20 wk of age, and after induction of acute diabetes with streptozotocin. 5 wk obese rats exhibit insulin hyperresponsive glucose uptake, whereas 20 wk obese rats show insulin resis
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10. The relationship between energy expenditure and environmental temperature in congenitally obese and non-obese Zucker rats.
The energy expenditure of normal and congenitally obese adult female Zucker rats has been measured by continuous indirect calorimetry for periods of 3-10 days at ambient temperatures varied from 30 to 5 degrees C. Rectal temperatures were also recorded. Exposure to cold caused no ill-effects in normal or obese rats. The rectal temperatures of obese rats were
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11. Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets
Overaccumulation of lipids in nonadipose tissues of obese rodents may lead to lipotoxic complications such as diabetes. To assess the pathogenic role of the lipogenic transcription factor, sterol regulatory element binding protein 1 (SREBP-1), we measured its mRNA in liver and islets of obese, leptin-unresponsive fa/fa Zucker diabetic fatty rats. Hepatic SRE
The National Academy of Sciences.
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12. Fatty liver induced in Zucker "fatty" (ff) rats by a semisynthetic diet rich in sucrose.
A new fatty liver model is described in which heredity plays a major role. A marked fatty liver develops when the homozygous mutant Zucker rat (ff or "fatty") is fed a semisynthetic diet enriched in sucrose. Lean littermates do not develop fatty liver on this experimental diet. Even old ff rats do not develop fatty livers on chow; the experimental diet is re