Receptores Aryl De Hidrocarbonetos Ahr
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1. Study the function of genes regulating the hypoxia state in determining the intensity inflammatory response. / Estudo da correlação entre a expressão de genes reguladores do estado de hipóxia e a intensidade da resposta inflamatória aguda.
Hypoxia occurs when the demand for molecular oxygen necessary to generate ATP is insufficient. Genes activated by hypoxia comprise the Hif-1a gene (Hypoxia-Inducible Factor 1a), Vegf-a (Vascular Endothelial Growth Factor a), Arnt and Vhl (von Hippel-Lindau). In this study we used lines of mice genetically selected for high (AIRmax) or low (AIRmin) acute infl
Publicado em: 2009