Recombinant Vaccines
Mostrando 1-12 de 567 artigos, teses e dissertações.
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1. Enhancing immune effects of a DNA vaccine against kidney cancer using CD40L as an adjuvant
The use of specific combinations of antigens and adjuvant represents a promising approach for increasing the immunogenicity of DNA vaccines. In the present study, we evaluated the immunity and antitumor effects of DNA vaccines with G250 as the target antigen in a mouse model of renal cell carcinoma. We constructed two recombinant plasmids, pVAX1-G250 and pVA
Braz. J. Pharm. Sci.. Publicado em: 25/11/2019
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2. Papillomaviruses: a systematic review
Abstract In the last decades, a group of viruses has received great attention due to its relationship with cancer development and its wide distribution throughout the vertebrates: the papillomaviruses. In this article, we aim to review some of the most relevant reports concerning the use of bovines as an experimental model for studies related to papillomavir
Genet. Mol. Biol.. Publicado em: 16/02/2017
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3. Epidemiology of Avian Infectious Laryngotracheitis with Special Focus to South America: an update
ABSTRACT Avian Infectious laryngotracheitis (AILT) is a respiratory tract disease of great importance because it causes significant economic losses in the poultry industry around the world. It is caused by a Gallid herpesvirus type 1, a member of the genus Iltovirus. The target system for Avian Infectious Laryngotracheitis virus (AILTV) infections is the res
Rev. Bras. Cienc. Avic.. Publicado em: 2016-12
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4. Immune response in hamsters immunised with a recombinant fragment of LigA from Leptospira interrogans, associated with carrier molecules
Immunisation with the C-terminal region of leptospiral immunoglobulin-like A protein (LigANI) has shown promising results against leptospirosis. We evaluated the humoral immune response and protection induced by LigANI associated with carboxyl multi-walled carbon nanotubes (COOH-MWCNTs), CpG oligodeoxynucleotides (CpG ODNs), or Alhydrogel. Animals immunised
Mem. Inst. Oswaldo Cruz. Publicado em: 13/10/2016
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5. Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis
Abstract: Visceral leishmaniasis (VL) is one of the most important tropical diseases worldwide. Although chemotherapy has been widely used to treat this disease, problems related to the development of parasite resistance and side effects associated with the compounds used have been noted. Hence, alternative approaches for VL control are desirable. Some metho
Rev. Soc. Bras. Med. Trop.. Publicado em: 2016-08
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6. Solubility as a limiting factor for expression of hepatitis A virus proteins in insect cell-baculovirus system
The use of recombinant proteins may represent an alternative model to inactivated vaccines against hepatitis A virus (HAV). The present study aimed to express the VP1 protein of HAV in baculovirus expression vector system (BEVS). The VP1 was expressed intracellularly with molecular mass of 35 kDa. The VP1 was detected both in the soluble fraction and in the
Mem. Inst. Oswaldo Cruz. Publicado em: 11/07/2016
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7. Infectious Bursal Disease: Pathogenicity and Immunogenicity of Vaccines
ABSTRACT The Infectious Bursal Disease (IBD) is a contagious viral disease that affects young chickens and may cause high morbidity and mortality. As the virus is very resistant to the environment, vaccination is required in case of high infection pressure. Due to variations in the virulence degree of the vaccines available to control IBD, this study aimed a
Rev. Bras. Cienc. Avic.. Publicado em: 2016-06
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8. The mc2-CMX vaccine induces an enhanced immune response against Mycobacterium tuberculosis compared to Bacillus Calmette-Guérin but with similar lung inflammatory effects
Although the attenuated Mycobacterium bovis Bacillus Calmette-Guérin (BCG) vaccine has been used since 1921, tuberculosis (TB) control still proceeds at a slow pace. The main reason is the variable efficacy of BCG protection against TB among adults, which ranges from 0-80%. Subsequently, the mc2-CMX vaccine was developed with promising results. Nonetheless,
Mem. Inst. Oswaldo Cruz. Publicado em: 2016-04
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9. Nanotechnology: meeting the future of Veterinary Parasitology Research
Abstract: The field of nanotechnology involves an array of different areas of expertize with the application of innovative products in Medicine, Engineering, and to a less extent to Veterinary Medicine. In our opinion, more research is needed, in special to Animal Parasitology, to develop state of the art products to solve old problems. Livestock, pets and w
Pesq. Vet. Bras.. Publicado em: 2015-10
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10. The use of halloysite clay and carboxyl-functionalised multi-walled carbon nanotubes for recombinant LipL32 antigen delivery enhanced the IgG response
We studied the feasibility of using halloysite clay nanotubes (HNTs) and carboxyl-functionalised multi-walled carbon nanotubes (COOH-MWCNTs) as antigen carriers to improve immune responses against a recombinant LipL32 protein (rLipL32). Immunisation using the HNTs or COOH-MWCNTs significantly increased the rLipL32-specific IgG antibody titres (p < 0.05) of G
Mem. Inst. Oswaldo Cruz. Publicado em: 23/01/2015
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11. Live bacterial vaccine vectors: An overview
Genetically attenuated microorganisms, pathogens, and some commensal bacteria can be engineered to deliver recombinant heterologous antigens to stimulate the host immune system, while still offering good levels of safety. A key feature of these live vectors is their capacity to stimulate mucosal as well as humoral and/or cellular systemic immunity. This enab
Braz. J. Microbiol.. Publicado em: 2014-12
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12. Production of leptospiral LipL32 antigen in Pichia pastoris and its use in an enzyme-linked immunosorbent assay
The production of recombinant LipL32 protein using Escherichia coli has been used extensively for the development of vaccines and diagnostic tests for leptospirosis. However, E. coli has demonstrated limitations, including low yield and lack of post-translational modifications. In this study, rLipL32 was produced in eukaryotic expression system (Pichia pasto
Braz. arch. biol. technol.. Publicado em: 31/01/2014