Regulation Of Muscle Contraction
Mostrando 1-12 de 100 artigos, teses e dissertações.
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1. Is there a role for voltage-gated Na+ channels in the aggressiveness of breast cancer?
Breast cancer is the most common cancer among women and its metastatic potential is responsible for numerous deaths. Thus, the need to find new targets for improving treatment, and even finding the cure, becomes increasingly greater. Ion channels are known to participate in several physiological functions, such as muscle contraction, cell volume regulation,
Braz J Med Biol Res. Publicado em: 05/06/2017
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2. Vascular O-GlcNAcylation augments reactivity to constrictor stimuli by prolonging phosphorylated levels of the myosin light chain
O-GlcNAcylation is a modification that alters the function of numerous proteins. We hypothesized that augmented O-GlcNAcylation levels enhance myosin light chain kinase (MLCK) and reduce myosin light chain phosphatase (MLCP) activity, leading to increased vascular contractile responsiveness. The vascular responses were measured by isometric force displacemen
Braz J Med Biol Res. Publicado em: 15/08/2014
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3. Metabolic regulation during sport events: factual interpretations and inadequate allegations
Different fuels are available to generate ATP for muscle activities during sport events. Glycogen from striated muscles and liver stores may be converted to lactic acid or almost completely oxidized to carbon dioxide (CO2), triacylglycerol within the muscle itself and fatty acids from adipose tissue could be converted to CO2 in acting muscles, some free amin
Rev. bras. educ. fís. esporte. Publicado em: 06/09/2013
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4. Construção e análise de mutantes fluorescentes da troponina I / Construction and analysis of fluorescent mutants of troponin I
Vertebrate striated muscle contraction is regulated by troponin (Tn). Tn is composed of three subunits: troponin I (TnI), troponin C (TnC) and troponin T (TnT). TnI has an inhibitory role that is neutralized by calcium binding to the regulatory sites in the N-domain of TnC, and TnT positions the troponin complex on the thin filament. In order to follow the C
Publicado em: 2001
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5. Role of thin-filament regulatory proteins in relaxation of colonic smooth muscle contraction
Coordinated regulation of smooth muscle contraction and relaxation is required for colonic motility. Contraction is associated with phosphorylation of myosin light chain (MLC20) and interaction of actin with myosin. Thin-filament regulation of actomyosin interaction is modulated by two actin-binding regulatory proteins: tropomyosin (TM) and caldesmon (CaD).
American Physiological Society.
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6. Regulation of receptor capping in mouse lymphoma T cells by Ca2+-activated myosin light chain kinase.
Several characteristics of receptor capping in lymphocyte membranes suggest similarities with mechanisms underlying control of contraction in smooth muscle fibers. Both capping and contraction are Ca2+ dependent and require metabolic energy. Contractile proteins such as actin and myosin are associated with the cap, as is calmodulin, which mediates the Ca2+ d
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7. siRNA-mediated knockdown of h-caldesmon in vascular smooth muscle
Smooth muscle contraction involves phosphorylation of the regulatory myosin light chain. However, this thick-filament system of regulation cannot account for all aspects of a smooth muscle contraction. An alternate site of contractile regulation may be in the thin-filament-associated proteins, in particular caldesmon. Caldesmon has been proposed to be an inh
American Physiological Society.
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8. Role of the short isoform of myosin light chain kinase in the contraction of cultured smooth muscle cells as examined by its down-regulation
GbaSM-4 cells, smooth muscle cells derived from brain basilar artery, which express both 210-kDa long and 130-kDa short isoforms of myosin light chain kinase (MLCK), were infected with an adenovirus vector carrying a 1.4-kb catalytic portion of MLCK–cDNA in an antisense orientation. Western blot analysis showed that the expression of short MLCK was depress
The National Academy of Sciences.
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9. Regulation of smooth muscle contraction/relaxation: paradigm shifts and quantifying arrows
Blackwell Science Inc.
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10. The time course and magnitude of blood flow changes in the human quadriceps muscles following isometric contraction.
Blood velocities in the human femoral artery were measured using pulsed bidirectional Doppler-ultrasound equipment before, during and after single isometric contractions of the quadriceps muscle group. After contraction periods lasting more than 20 s (long) and of tensions from 10% up to 75% of maximal voluntary contraction (m.v.c.), an increase in blood vel
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11. Three New Classes of Mutations in the Caenorhabditis Elegans Muscle Gene Sup-9
We are studying five interacting genes involved in the regulation or coordination of muscle contraction in Caenorhabditis elegans. A distinctive ``rubber-ban'' muscle-defective phenotype was previously shown to result from rare altered-function mutations in either of two of these genes, unc-93 and sup-10. Null mutations in sup-9, sup-10, sup-18 or unc-93 act
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12. Mitochondrial regulation of phosphocreatine/inorganic phosphate ratios in exercising human muscle: a gated 31P NMR study.
31P NMR is used to determine the relationship between work output in the exercising human forearm and the steady-state capability of oxidative phosphorylation as measured by the phosphocreatine/inorganic phosphate ratio (PCr/Pi). Exercise intensities (one contraction per 5 sec) permitting comfortable continuation of activity for greater than 1 hr produced PC