Respiratory System Drug Effects
Mostrando 1-12 de 14 artigos, teses e dissertações.
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1. Study of inhaler technique in asthma patients: differences between pediatric and adult patients
Objective: Inhaler technique comprises a set of procedures for drug delivery to the respiratory system. The oral inhalation of medications is the first-line treatment for lung diseases. Using the proper inhaler technique ensures sufficient drug deposition in the distal airways, optimizing therapeutic effects and reducing side effects. The purposes of this
J. bras. pneumol.. Publicado em: 2015-10
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2. Efeitos da adição de polietilenoglicol ao surfactante exógeno no tratamento da síndrome de aspiração de mecônio em coelhos recém-nascidos / Effects of polyethylene glycol added to exogenous surfactant for meconium aspiration syndrome treatment in newborn rabbits
Meconium is known to be a potent inactivator of pulmonary surfactant, and exogenous surfactant treatment for meconium aspiration syndrome failed to decrease mortality. A number of studies have shown, in vitro, that the addition of polymers such as polyethylene glycol (PEG) to the surfactant maintains good surface activity in the presence of meconium. In the
Publicado em: 2007
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3. "Determinantes funcionais e morfológicos de ação de droga sobre os pulmões utilizando um modelo experimental em cobaias sob uso do cloridrato de fluoxetina" / Functional and morphological determinants of drug action on the lungs through an experimental model in guinea pigs under use of fluoxetine
Muito se tem pesquisado sobre os efeitos adversos dos antidepressivos tricíclicos (p.e. imipramina) sobre o sistema respiratório, embora pouco ou quase nada se encontre com relação a tal aspecto na literatura médica sobre a fluoxetina (Prozac®) um inibidor seletivo da recaptação de serotonina, até porque esta droga começou a ser utilizada somente
Publicado em: 2005
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4. Pulmonary complications of smoked substance abuse.
After tobacco, marijuana is the most widely smoked substance in our society. Studies conducted within the past 15 years in animals, isolated tissues, and humans indicate that marijuana smoke can injure the lungs. Habitual smoking of marijuana has been shown to be associated with chronic respiratory tract symptoms, an increased frequency of acute bronchitic e
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5. Recapitulation in Saccharomyces cerevisiae of Cytochrome b Mutations Conferring Resistance to Atovaquone in Pneumocystis jiroveci
Pneumocystis jiroveci (human-derived P. carinii) is an opportunistic pathogenic fungus which causes pneumonia and is life-threatening in immunocompromised individuals. Spontaneously acquired resistance to atovaquone, a hydroxynaphthoquinone that is used to treat P. jiroveci infections, was linked to mutations in the mitochondrially encoded cytochrome b gene.
American Society for Microbiology.
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6. Longitudinal trends in prescribing for elderly patients: two surveys four years apart.
BACKGROUND. Elderly people are prescribed more drugs than younger people. The consequences of excessive or unwise prescribing, such as drug interactions, are well known. AIM. A longitudinal study was undertaken to examine levels and patterns of prescribed drug use among a group of elderly people. METHOD. Use of prescribed drugs by a sample of elderly people
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7. Antibiotic inhibition of the respiratory burst response in human polymorphonuclear leukocytes.
Recently we found that certain antibiotics which are markedly concentrated by human polymorphonuclear leukocytes (PMN) failed to kill susceptible, intraphagocytic Staphylococcus aureus, even though cellular drug levels were quite high. The possibility that specific antibiotics might adversely affect phagocyte antibacterial function was considered. Thus, we s
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8. Effects of atovaquone and other inhibitors on Pneumocystis carinii dihydroorotate dehydrogenase.
Dihydroorotate dehydrogenase (DHOD) is a pyrimidine biosynthetic enzyme which is usually directly linked to the mitochondrial respiratory chain. Antimalarial naphthoquinones such as atovaquone (566c80) inhibit malarial DHOD by inhibiting electron transport. Since atovaquone also has therapeutic activity against Pneumocystis carinii, the P. carinii DHOD may a
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9. Effect of bronchodilators on the cough response to inhaled citric acid in normal and asthmatic subjects.
Coughing was induced in seven normal and eight asthmatic subjects by giving successive inhalations of citric acid aerosols of progressively higher concentration (range 0.5-32%). A baseline cough response was obtained on each of four experimental days, and there was no significant difference between days in this respect. Then the subjects received by inhalati
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10. Isoprenoid metabolism is required for stimulation of the respiratory burst oxidase of HL-60 cells.
The formation of oxygen radicals by phagocytic cells occurs through the activation of a multiple-component NADPH oxidase system. An unidentified low molecular weight GTP-binding protein has been proposed to modulate the activity of the NADPH oxidase. The low molecular weight GTP-binding proteins undergo posttranslational processing, including an initial cova
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11. Effects of pentamidine isethionate on Saccharomyces cerevisiae.
We used Saccharomyces cerevisiae as a model system in which to examine the mechanism of action of the anti-Pneumocystis drug pentamidine. Pentamidine at low concentrations inhibited S. cerevisiae growth on nonfermentable carbon sources (50% inhibitory concentration [IC50] of 1.25 micrograms/ml in glycerol). Pentamidine inhibited growth on fermentable energy
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12. Severe spontaneous bradycardia associated with respiratory disruptions in rat pups with fewer brain stem 5-HT neurons
The medullary 5-HT system has potent effects on heart rate and breathing in adults. We asked whether this system mitigates the respiratory instability and bradycardias frequently occurring during the neonatal period. 5,7-Dihydroxytryptamine (5,7-DHT) or vehicle was administered to rat pups at postnatal day 2 (P2), and we then compared the magnitude of bradyc
American Physiological Society.