Retinal Degeneration
Mostrando 1-12 de 244 artigos, teses e dissertações.
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1. Optical coherence tomography findings in bipolar disorder: a preliminary receiver operating characteristic analysis on ganglion cell layer volume for diagnosis
Abstract Background Optical coherence tomography (OCT) has been recently used to investigate neuropsychiatric disorders. Objective The aim of this study was to compare the retinal nerve fiber layer thickness (RNFLT) and the ganglion cell layer (GCL) volume in patients with type 1 bipolar disorder (BPD1, diagnosed according to DSM 5) to the values in heal
Arch. Clin. Psychiatry (São Paulo). Publicado em: 25/11/2019
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2. A Novel Missense Mutation in SRD5A3 Causes Congenital Disorder of Glycosylation Type I (Cerebello-Ocular Syndrome)
Abstract A consanguineous Qatari family having an autosomal recessive disorder characterized by severe mental retardation, cerebellar vermis hypoplasia, retinal degeneration, optic nerve atrophy, ataxic gait, and seizures was studied for identification of the offending gene and mutation. Homozygosity mapping identified an 11.4 Mb critical interval at 4q12 to
J. inborn errors metab. screen.. Publicado em: 15/07/2019
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3. Rescuing axons from degeneration does not affect retinal ganglion cell death
After a traumatic injury to the central nervous system, the distal stumps of axons undergo Wallerian degeneration (WD), an event that comprises cytoskeleton and myelin breakdown, astrocytic gliosis, and overexpression of proteins that inhibit axonal regrowth. By contrast, injured neuronal cell bodies show features characteristic of attempts to initiate the r
Braz J Med Biol Res. Publicado em: 18/03/2016
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4. SIRT1 negatively regulates amyloid-beta-induced inflammation via the NF-κB pathway
Chronic inflammation induced by amyloid-beta (Aβ) plays a key role in the development of age-related macular degeneration (AMD), and matrix metalloproteinase-9 (MMP-9), interleukin (IL)-6, and IL-8 may be associated with chronic inflammation in AMD. Sirtuin 1 (SIRT1) regulates inflammation via inhibition of nuclear factor-kappa B (NF-κB) signaling, and res
Braz J Med Biol Res. Publicado em: 2013-08
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5. Finding new approaches to treat retinitis pigmentosa caused by mutations in the photoreceptor rhodopsin. / Em busca de novos métodos de tratamento para a retinose pigmentar causada por mutações na rodopsina.
Retinitis Pigmentosa (RP) is an inherited disease that progressively leads to blindness. More than 150 mutations associated with RP are known in rhodopsin, causing its misfolding. This thesis tested the hypothesis that small molecules can rescue folded rhodopsin and/or reduce photoreceptor cell death. RP mutations, N15S and P23H, revealed differences in char
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/07/2012
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6. Estudo das alterações retinianas em olhos de coelhos após injeções intravítreas seriadas de infliximabe / Study of retinal alterations in eyes of rabbits after serial intravitreous injections of infliximab
O objetivo deste trabalho foi determinar os níveis de toxicidade de duas e três aplicações intravítreas de infliximabe na retina e coroide de coelhos albinos, por meio de exames clínicos oftalmológicos, eletrorretinográficos e histológicos. Foram utilizados doze coelhos albinos (24 olhos) da raça New Zealand. Cada olho recebeu duas (n=10 olhos) ou
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/10/2011
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7. Estudo das alterações retinianas em olhos de coelhos após injeções intravítreas seriadas de infliximabe / Study of retinal alterations in eyes of rabbits after serial intravitreous injections of infliximab
O objetivo deste trabalho foi determinar os níveis de toxicidade de duas e três aplicações intravítreas de infliximabe na retina e coroide de coelhos albinos, por meio de exames clínicos oftalmológicos, eletrorretinográficos e histológicos. Foram utilizados doze coelhos albinos (24 olhos) da raça New Zealand. Cada olho recebeu duas (n=10 olhos) ou
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/10/2011
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8. Aceruloplasminemia: a rare disease - diagnosis and treatment of two cases
Aceruloplasminemia is a rare autosomal recessive disease in which a mutation leads to the absence or dysfunction of ceruloplasmin. Deficiency of this enzyme leads to the accumulation of iron in various organs; aceruloplasminemia is usually characterized by diabetes, retinal degeneration and neurological disorders. Diagnosis is suspected by the presence of el
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2011-10
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9. Caspase dependence of the death of neonatal retinal ganglion cells induced by axon damage and induction of autophagy as a survival mechanism
We examined the degeneration of post-mitotic ganglion cells in ex-vivo neonatal retinal explants following axon damage. Ultrastructural features of both apoptosis and autophagy were detected. Degenerating cells reacted with antibodies specific for activated caspase-3 or -9, consistent with the presence of caspase activity. Furthermore, peptidic inhibitors of
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-10
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10. Bevacizumab INTRA-VITREOUS: ANALYSIS OF RETINAL TOXICITY AFTER 3 MONTHS IN EYES OF RABBITS NOT ALBINO / BEVACIZUMABE INTRA-VÍTREO: ANÁLISE DA TOXICIDADE RETINIANA APÓS 3 MESES EM OLHOS DE COELHOS NÃO ALBINOS
Antiangiogenesis therapy has become a first-line treatment for neovascular age-related macular degeneration (AMD). Bevacizumab has proven to be efficient and cost effective, however its use in AMD is still off-label. PURPOSES: Evaluating the histological toxicity of bevacizumab on the neurosensorial retina (NSR) and the retinal pigmented epithelium (RPE) in
Publicado em: 2009
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11. BEVACIZUMABE INTRA-VÍTREO: ANÁLISE DA TOXICIDADE RETINIANA APÓS 3 MESES EM OLHOS DE COELHOS NÃO ALBINOS / Bevacizumab INTRA-VITREOUS: ANALYSIS OF RETINAL TOXICITY AFTER 3 MONTHS IN EYES OF RABBITS NOT ALBINO
A terapia anti-angiogênica tornou-se o tratamento de primeira linha para a forma neovascular da degeneração macular relacionada à idade. O Bevacizumabe é uma droga com boa eficácia e custo-efetividade, porém seu uso nesta doença ainda é considerado off-label. OBJETIVOS: Avaliar a toxicidade sobre a retina neurossensorial (RNS) e epitélio pigmentado
Publicado em: 2009
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12. Identification of a new human mtDNA polymorphism (A14290G) in the NADH dehydrogenase subunit 6 gene
Leber's hereditary optic neuropathy (LHON) is a maternally inherited form of retinal ganglion cell degeneration leading to optic atrophy in young adults. Several mutations in different genes can cause LHON (heterogeneity). The ND6 gene is one of the mitochondrial genes that encodes subunit 6 of complex I of the respiratory chain. This gene is a hot spot gene
Brazilian Journal of Medical and Biological Research. Publicado em: 2006-06