Retrotransposon Line 1
Mostrando 1-12 de 31 artigos, teses e dissertações.
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1. Citogenética clássica e molecular do boto-vermelho Inia geoffrensis (Blainville, 1817)
O golfinho da Amazônia ou boto-vermelho (Iniidae, Inia geoffrensis) é um golfinho fluvial endêmico das bacias Amazônica e do Orinoco. Para compreender a organização genômica desta espécie e gerar marcadores para investigar as relações evolutivas deste golfinho em relação a outros cetáceos, foram realizadas análises de citogenética clássica e
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/04/2011
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2. Transferência horizontal de seqüências de minicírculos de kDNA de Trypanosoma cruzi e herança vertical das mutações
Neste estudo, nós confirmamos e estendemos o conhecimento sobre a transferência de minicírculos de kDNA de Trypanosoma cruzi para o genoma humano. Foram analisadas cinco famílias cujos parentais (G0) eram portadores da doença de Chagas. Foi possível observar a integração de kDNA de T. cruzi no genoma de todos os chagásicos estudados. Concomitantemen
Publicado em: 2008
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3. Herança vertical de seqüências de minicírculos de kDNA de Trypanosoma cruzi integradas no genoma de células germinativas humanas
O presente trabalho é o primeiro relato de integração de seqüências provenientes de um protozoário para o genoma de células germinativas humanas. Neste estudo, nós documentamos a integração de minicírculos de kDNA de Trypanosoma cruzi no genoma de células germinativas e a transferência vertical dessas mutações para os descendentes. Foram anali
Publicado em: 2008
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4. Hitchhiking Trypanosoma cruzi minicircle DNA affects gene expression in human host cells via LINE-1 retrotransposon
The horizontal transfer of Trypanosoma cruzi mitochondrial minicircle DNA to the genomes of naturally infected humans may play an important role in the pathogenesis of Chagas disease. Minicircle integrations within LINE-1 elements create the potential for foreign DNA mobility within the host genome via the machinery associated with this retrotransposon. Here
Memórias do Instituto Oswaldo Cruz. Publicado em: 2006-12
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5. Reverse transcriptase encoded by a retrotransposon from the trypanosomatid Crithidia fasciculata.
The long interspersed nuclear element (LINE)-like elements are a distinct family of eukaryotic transposons that contain a long open reading frame with limited sequence homology to retroviral reverse transcriptases. Unlike many retrotransposons, they lack long terminal repeats. The mechanism by which LINE-like elements move within the genomes of their hosts r
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6. Copia-, Gypsy- and Line-like Retrotransposon Fragments in the Mitochondrial Genome of Arabidopsis Thaliana
Several retrotransposon fragments are integrated in the mitochondrial genome of Arabidopsis thaliana. These insertions are derived from all three classes of nuclear retrotransposons, the Ty1/copia-, Ty3/gypsy- and non-LTR/LINE-families. Members of the Ty3/gypsy group of elements have not yet been identified in the nuclear genome of Arabidopsis. The varying d
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7. A potential role for RNA interference in controlling the activity of the human LINE-1 retrotransposon
Long interspersed nuclear elements (LINE-1 or L1) comprise 17% of the human genome, although only 80–100 L1s are considered retrotransposition-competent (RC-L1). Despite their small number, RC-L1s are still potential hazards to genome integrity through insertional mutagenesis, unequal recombination and chromosome rearrangements. In this study, we provide s
Oxford University Press.
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8. SLACS retrotransposon from Trypanosoma brucei gambiense is similar to mammalian LINEs.
We have characterized a retrotransposon in Trypanosoma brucei gambiense uniquely associated with the spliced-leader (SL) RNA gene cluster (Spliced Leader Associated Conserved Sequence, SLACS). There are nine copies of SLACS and DNA sequence analysis of one shows the hallmarks of Line-1 like elements. SLACS has generated a 49 bp target DNA duplication at its
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9. Precise excision of the retrotransposon gypsy from the forked and cut loci in a genetically unstable D. melanogaster strain.
The genetically unstable Mutator Strain of D. melanogaster is characterised by a high frequency of spontaneous mutations and their reversions. Three forked mutants were obtained independently and several reversions arose spontaneously with frequency of 10(-3)-10(-4). The sites of integration and excision of the gypsy retrotransposon were analysed by Southern
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10. The Insertional History of an Active Family of L1 Retrotransposons in Humans
As humans contain a currently active L1 (LINE-1) non-LTR retrotransposon family (Ta-1), the human genome database likely provides only a partial picture of Ta-1-generated diversity. We used a non-biased method to clone Ta-1 retrotransposon-containing loci from representatives of four ethnic populations. We obtained 277 distinct Ta-1 loci and identified an ad
Cold Spring Harbor Laboratory Press.
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11. Silencing of Retrotransposons in Arabidopsis and Reactivation by the ddm1 Mutation
Gene silencing associated with repeated DNA sequences has been reported for many eukaryotes, including plants. However, its biological significance remains to be determined. One important function that has been proposed is the suppression of transposons. Here, we address transposon suppression by examining the behavior of the tobacco retrotransposon Tto1 and
American Society of Plant Physiologists.
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12. Targeted Nuclear Import of Open Reading Frame 1 Protein Is Required for In Vivo Retrotransposition of a Telomere-Specific Non-Long Terminal Repeat Retrotransposon, SART1
Non-long terminal repeat (non-LTR) retrotransposons, most of which carry two open reading frames (ORFs), are abundant mobile elements that are distributed widely among eukaryotes. ORF2 encodes enzymatic domains, such as reverse transcriptase, that are conserved in all retroelements, but the functional roles of ORF1 in vivo are little understood. We show with
American Society for Microbiology.