Rhenium 188
Mostrando 1-8 de 8 artigos, teses e dissertações.
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1. Estudo comparativo da marcação do anticorpo anti-CD20 com 188Re / Comparative studies of antibody anti-CD20 labeled with 188Re
A Medicina Nuclear é uma modalidade de particular importância em oncologia e a investigação de novos radiofármacos direcionados a tumores, seja para diagnóstico e/ou terapia, é uma área de interesse para os pesquisadores. Rituximab (RTX) é um anticorpo monoclonal (AcM) quimérico (IgG 1) que se liga especificamente ao antígeno CD20 com alta afinida
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/02/2010
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2. Technetium and rhenium: coordination chemistry and nuclear medical applications
Compostos de coordenação do elemento radioativo tecnécio são empregados para diagnóstico em medicina nuclear, sendo vários complexos do nuclídeo emissor de radiação gama 99mTc usados rotineiramente na obtenção de imagens de órgãos. As tendências modernas da química radiofarmacêutica concentram-se na marcação de moléculas biologicamente ati
Journal of the Brazilian Chemical Society. Publicado em: 2006-12
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3. Estudos de marcação do etidronato com 188Re proveniente de diferentes geradores de 188W/ 188Re / Studies of HEDP labelled with 188Re from different generators of 188W / 188Re.
The widespread interest in 188Re for therapeutic applications, is due to its attractive 16,9 hours half-life, emission of a βֿ particle with maximum energy of 2.12 MeV and gama-ray of 155 keV suitable for imaging. This work presents the radiollabeling of HEDP (etidronate) with 188Re eluted from alumina-based 188W/188Re generators and tungstate-bas
Publicado em: 2006
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4. Liquid kit for preparation of 188rhenium-etidronate
O objetivo desse trabalho é a preparação de um kit líquido para a radiomarcação do 188Re-HEDP (hidroxietilideno - difosfonato). O 188Re foi obtido por meio do gerador 188W/188Re em alumina. Este trabalho reporta a experiência do preparo de um kit frio armazenado por até duas semanas. Os parâmetros estudados para obter melhores rendimentos de marcaç
Brazilian Archives of Biology and Technology. Publicado em: 2005-10
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5. Physico-chemical characterisation and biological evaluation of 188-Rhenium colloids for radiosynovectomy
BioMed Central.
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6. Design and characterization of α-melanotropin peptide analogs cyclized through rhenium and technetium metal coordination
α-Melanocyte stimulating hormone (α-MSH) analogs, cyclized through site-specific rhenium (Re) and technetium (Tc) metal coordination, were structurally characterized and analyzed for their abilities to bind α-MSH receptors present on melanoma cells and in tumor-bearing mice. Results from receptor-binding assays conducted with B16 F1 murine melanoma cells
The National Academy of Sciences.
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7. Ionizing radiation delivered by specific antibody is therapeutic against a fungal infection
There is an urgent need for new antimicrobial therapies to combat drug resistance, new pathogens, and the relative inefficacy of current therapy in compromised hosts. Ionizing radiation can kill microorganisms quickly and efficiently, but this modality has not been exploited as a therapeutic antimicrobial strategy. We have developed methods to target ionizin
National Academy of Sciences.
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8. Dead cells in melanoma tumors provide abundant antigen for targeted delivery of ionizing radiation by a mAb to melanin
Melanoma is a cancer with a rising incidence, and metastatic disease is almost always lethal. We investigated the feasibility of targeting melanin, an intracellular melanocyte pigment, to deliver cytotoxic radiation to human melanoma cells in vivo by using a melanin-binding mAb (6D2). Nude mice bearing MNT1 pigmented human melanoma tumors were treated with m
National Academy of Sciences.