Ribonucleosides
Mostrando 1-12 de 75 artigos, teses e dissertações.
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1. Estudos de Novas Metodologias Sintéticas para Heterocíclicos Quinolônicos, Triazólicos e Síntese de Catalisadores Quirais
In order to obtain quinolone nucleosides a new methodology based on construction of the heterocyclic ring at the carbohydrate moiety was devised. The carbohydrates: 1-methoxy-2,3-O-isopropylidene-α-D-ribofuranose (108), 1-methoxy-2,3-O-isopropylidene-5-O-methanesulfonyl-β-D-ribofuranose (109a) and 1-methoxy-2,3-O-isopropylidene-5-O-p-toluenesulfony
Publicado em: 2004
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2. Synthesis and evaluation of the biological activity of new desoxinucleosides quinolonics, ribonucleosides pyrimido[5,4-c]quinolinics and derived new quinolinics containing tryazolics substitues / Síntese e avaliação da atividade biológica de novos desoxinucleosídeos quinolônicos, ribonucleosídeos pirimido[5,4-c]quinolínicos e novos derivados quinolônicos contendo substituintes triazólicos
Neste trabalho foram sintetizados os heterociclos 3-carbetoxi-4(1H)-quinolona 98a-98o contendo substituintes flúor, cloro, bromo, iodo, metil, metoxi e nitro nas posições 6 ou 7, em rendimentos de 72 a 87%. Estes foram sililados com N,O-bis(trimetilsilil)trifluoracetamida (BSTFA) sendo posteriormente submetidos à reação de acoplamento com 1-O-acetil-2,
Publicado em: 2004
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3. Síntese de Novos Nucleosídeos Quinolônicos não Naturais como Potenciais Agentes Antivirais / Synthesis of New Quinolonics Nucleosides no Natural by Antivirals Potential Agents
The interesting biological activities of synthetic quinoline derivatives as antibacterial and antiviral agents urged many research groups to construct numerous analogues of such compounds. Since the discovery of acyclovir as a potent and selective antiherpes virus agent, considerable interest has been focused in the synthesis of novel acyclonucleoside analog
Publicado em: 2003
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4. An Efficient and Short Route for the Synthesis of Reverse Pyrrole Ribonucleosides
Neste trabalho estão descritas as sínteses dos ribonucleosídeos pirrólicos reversos 5-C-(4-acetil-5-metil-pirrol-1-il)-2,3-O-isopropilideno-5-desoxi- beta-D-ribofuranosídeo de metila (10), 5-C-(4-etoxicarbonil-5-metil-pirrol-1-il)-2,3-O-isopropilideno-5-desoxi- beta-D-ribofuranosídeo de metila (11), 5-C-(4-acetil-5-metil-pirrol-1-il)-5-desoxi-beta-D-ri
Journal of the Brazilian Chemical Society. Publicado em: 2002-06
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5. Selective 2'-benzoylation at the cis 2',3'-diols of protected ribonucleosides. New solid phase synthesis of RNA and DNA-RNA mixtures.
5'-0-(Dimethoxytrityl)-2'-0-(benzoyl or 3,4,5-trimethoxybenzoyl)-base protected ribonucleosides have been prepared by selective benzoylation of the 2'-hydroxyl group. The isomerization of the 2'-benzoates to the 3'-benzoates was studied. The protected ribonucleosides have been converted to either methylphosphochloridites or methylphosphoamidites and used to
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6. 2′-O-Methylation of Adenosine, Guanosine, Uridine, and Cytidine in RNA of Isolated Rat Liver Nuclei
Nuclei isolated from rat liver, when incubated with methyl-labeled S-adenosylmethionine, incorporated label into 2′-O-methyladenosine, 2′-O-methylguanosine, 2′-O-methyluridine, and 2′-O-methylcytidine of endogenous nuclear RNA. Addition of ribosomal RNA from wheat germ to the reaction markedly stimulated 2′-O-methylation of total RNA. The relative
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7. The chemical synthesis of oligoribonucleotides VII. A comparison of condensing agents in the coupling of silylated ribonucleosides.
The t-butyldimethylsilyl group is shown to be an ideal protecting group for the 2T-hydroxyl function of ribonucleosides during the synthesis of ribonucleotides using any of nine commonly used condensing agents. The phosphite coupling procedure compares favorably with all of the widely used condensing agents and provides a most convenient route to the key int
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8. Intracellular lymphocyte activation and carrier-mediated transport of C8-substituted guanine ribonucleosides.
The studies described in this report constitute evidence substantiating that certain exogenous nucleoside derivatives can activate lymphocytes by acting intracellularly. These molecules, the C8-substituted guanine ribonucleosides, have recently been demonstrated to exert potent immunostimulatory and immunoregulatory activities both in vitro and in vivo. The
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9. Cytokinin-Active Ribonucleosides in Phaseolus RNA: I. IDENTIFICATION IN tRNA FROM ETIOLATED PHASEOLUS VULGARIS L. SEEDLINGS 1
The cytokinin-active ribonucleosides present in tRNA from etiolated Phaseolus vulgaris L. seedlings have been isolated and identified as cis-ribosylzeatin, 2-methylthio-ribosylzeatin, and N6-(Δ2-isopentenyl)-adenosine. The structures of the compounds were established on the basis of their chromatographic properties and the mass spectra of their permethylate
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10. In Vitro Activities of Benzimidazole d- and l-Ribonucleosides against Herpesviruses
Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), varicella-zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr virus (EBV), human herpesvirus 6 (HHV-6), and human herpesvirus 8 (HHV-8) are responsible for a number of clinical manifestations in both normal and immunocompromised individuals. The parent benzimidazole ribonucleosides evaluated in this s
American Society for Microbiology.
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11. 15N NMR spectra of wyosine and related ribonucleosides.
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12. ANTIBODIES SPECIFIC FOR RIBONUCLEOSIDES AND RIBONUCLEOTIDES AND THEIR REACTION WITH DNA*