Rotavirus Vaccines
Mostrando 1-12 de 47 artigos, teses e dissertações.
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1. Molecular characterization of group A rotavirus before and after the introduction of vaccines in Brazil
ABSTRACTINTRODUCTION:In this study, the molecular characteristics of group A rotavirus (RVA) were compared in samples obtained before and after RVA vaccine-introduction in Brazil.METHODS:Eighty samples were screened for the presence of RVA. Positive samples were molecularly analyzed.RESULTS:RVA positivity was 16.9%, with a predominance of G2P[4]. Periods: pr
Rev. Soc. Bras. Med. Trop.. Publicado em: 2015-10
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2. Inhibition of rotavirus ECwt infection in ICR suckling mice by N-acetylcysteine, peroxisome proliferator-activated receptor gamma agonists and cyclooxygenase-2 inhibitors
Live attenuated vaccines have recently been introduced for preventing rotavirus disease in children. However, alternative strategies for prevention and treatment of rotavirus infection are needed mainly in developing countries where low vaccine coverage occurs. In the present work, N-acetylcysteine (NAC), ascorbic acid (AA), some nonsteroidal anti-inflammato
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-09
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3. Avaliações econômicas de programas de vacinação: as estimativas de custos em intervenções preventivas / Economic evaluations of vaccination programmes: cost estimates of preventive interventions
Esta tese representa o aprofundamento do estudo das estimativas de custos, componente integrante e determinante das avaliações econômicas, enquanto parte do projeto de pesquisa Estudos de custo-efetividade da incorporação de novas vacinas à rotina do Programa Nacional de Imunizações: Rotavírus, Varicela, Pneumocócica conjugada, Meningocócica C con
Publicado em: 2009
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4. Caracterização molecular dos genes de VP1, VP2, VP3, VP4 e VP7 de amostras de rotavírus a genótipo GP5[8] circulando no Brasil entre 1985 e 2005 / Molecular characterization of genes VP1, VP2, VP3, VP4 and VP7 of rotavirus samples from the genotype GP5 [8] circulating in Brazil between 1985 and 2005
Nas décadas de 80 e início de 90 os rotavírus A (RV-A) de genótipo G5, comum em suínos, equinos e bovinos eram detectados com frequência em amostras fecais de crianças brasileiras. Após 1996, deixou de circular em caráter endêmico, tornando-se apenas esporadicamente detectado, enquanto o genótipo G9 começou a ser detectado com frequência. Esta s
Publicado em: 2009
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5. Molecular characterization of group A rotavirus isolates obtained from hospitalized children in Salvador, Bahia, Brazil
Rotavirus is a major cause of infectious diarrhea in infants and young children. The objective of this study was to characterize the genotypes of Human Rotavirus found in children hospitalized with acute diarrhea in the Pediatric Hospital Prof. Hosannah de Oliveira of the UFBA in Salvador, Bahia, Brazil, during the years of 1999, 2000 and 2002. Fecal samples
Brazilian Journal of Infectious Diseases. Publicado em: 2007-02
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6. Caracterização dos genótipos de rotavírus humano isolados de crianças hospitalizadas com quadros diarréicos em Salvador, Bahia. / Genotype characterization of human rotavirus isolated from children hospitalized with diarrheal episodes in Salvador -Bahia.
Human Rotaviruses are the most important etiologic agents of acute diarrhea in infants and young children worldwide, being responsible in developing countries for a large number of pediatric hospitalizations and a high impact on infant mortality. Our aim was to characterize the genotypes of human Rotavirus found in children hospitalized with acute diarrhea i
Publicado em: 2004
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7. Rotavirus vaccines: an overview.
Rotavirus vaccine development has focused on the delivery of live attenuated rotavirus strains by the oral route. The initial "Jennerian" approach involving bovine (RIT4237, WC3) or rhesus (RRV) rotavirus vaccine candidates showed that these vaccines were safe, well tolerated, and immunogenic but induced highly variable rates of protection against rotavirus
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8. Protective Immunity Induced by Oral Immunization with a Rotavirus DNA Vaccine Encapsulated in Microparticles
DNA vaccines are usually given by intramuscular injection or by gene gun delivery of DNA-coated particles into the epidermis. Induction of mucosal immunity by targeting DNA vaccines to mucosal surfaces may offer advantages, and an oral vaccine could be effective for controlling infections of the gut mucosa. In a murine model, we obtained protective immune re
American Society for Microbiology.
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9. Magnitude of Serum and Intestinal Antibody Responses Induced by Sequential Replicating and Nonreplicating Rotavirus Vaccines in Gnotobiotic Pigs and Correlation with Protection
A sequential mucosal prime-boost vaccine regimen of oral attenuated (Att) human rotavirus (HRV) priming followed by intranasal (i.n.) boosting with rotavirus protein VP2 and VP6 rotavirus-like particles (2/6-VLPs) has previously been shown to be effective for induction of intestinal antibody-secreting cell (ASC) responses and protection in gnotobiotic pigs.
American Society for Microbiology.
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10. Bovine rotavirus serotypes and their significance for immunization.
Neutralization assays on calf fecal rotavirus with antisera to two previously described bovine rotavirus serotypes allowed the isolation of four rotaviruses belonging to a distinct third serotype. In a survey of 85 calf isolates, 80 rotaviruses belonged to serotype 1 (91%), 1 belonged to serotype 2 (1%), and 4 belonged to serotype 3 (5%). Serotypes 1 and 2 w
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11. Comparison of immunoglobulin A (IgA), IgG, and IgM enzyme-linked immunosorbent assays, plaque reduction neutralization assay, and complement fixation in detecting seroresponses to rotavirus vaccine candidates.
In a phase 1 study to evaluate human-rhesus rotavirus reassortant vaccines, 116 infants 1 to 5 months of age received one of the following five preparations: the serotype 1 reassortant, the serotype 2 reassortant, rhesus rotavirus (serotype 3), a bivalent preparation (serotypes 1 and 3), or a placebo. Seroresponses to the different vaccines were measured by
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12. Immunodominance of the VP4 neutralization protein of rotavirus in protective natural infections of young children.
Natural infection by very similar strains of rotavirus during the 1988-1989 rotavirus season in Cincinnati, Ohio, provided complete protection of young children against subsequent rotavirus illnesses for a period of at least 2 years. Using this limited strain variability, we characterized the association between the titers of antibody to either the VP4 or th