Saporin
Mostrando 1-11 de 11 artigos, teses e dissertações.
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1. Effects of septal cholinergic lesion on rat exploratory behavior in an open-field
The medial septum participates in the modulation of exploratory behavior triggered by novelty. Also, selective lesions of the cholinergic component of the septohippocampal system alter the habituation of rats to an elevated plus-maze without modifying anxiety indices. We investigated the effects of the intraseptal injection of the cholinergic immunotoxin 192
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-02
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2. Efeitos da lesão colinérgica específica do núcleo septal medial no comportamento exploratório de ratos no labirinto em cruz elevado em um paradigma teste-reteste. / Effects of specific cholinergic lesion on the medial septal nucleus on the rat exploratory behavior in the elevated plus-maze in a test-retest paradigm.
O presente estudo investigou o efeito da lesão imunotóxica colinérgica específica do núcleo septal medial sobre o comportamento exploratório de ratos no labirinto em cruz elevado, em um paradigma teste-reteste, com analise minuto a minuto da primeira sessão. Uma análise bioquímica detectou uma diminuição da atividade da acetilcolinesterase no hipo
Publicado em: 1999
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3. Elimination of smooth muscle cells in experimental restenosis: targeting of fibroblast growth factor receptors.
Factors in plasma and platelets do not fully account for the proliferation of smooth muscle cells in vascular injury, implying that additional factors are involved. Recently, we and others have observed that vascular injury regulates basic fibroblast growth factor, suggesting a further role for this pleiotropic factor. We report here that injury of rat arter
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4. Lesions of the nucleus basalis magnocellularis induced by 192 IgG-saporin block memory enhancement with posttraining norepinephrine in the basolateral amygdala
Extensive evidence indicates that drugs and stress hormones act in the basolateral amygdala (BLA) to modulate memory consolidation. The BLA projects to the nucleus basalis magnocellularis (NBM), which sends broad cholinergic projections to the neocortex. NBM-cortex projections have been implicated in learning, memory storage, and plasticity. The current stud
The National Academy of Sciences.
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5. Cholinergic Modulation of Visual Attention and Working Memory: Dissociable Effects of Basal Forebrain 192-IgG-saporin Lesions and Intraprefrontal Infusions of Scopolamine
Two experiments examined the effects of reductions in cortical cholinergic function on performance of a novel task that allowed for the simultaneous assessment of attention to a visual stimulus and memory for that stimulus over a variable delay within the same test session. In the first experiment, infusions of the muscarinic receptor antagonist scopolamine
Cold Spring Harbor Laboratory Press.
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6. T-cell reconstitution without T-cell immunopathology in two models of T-cell-mediated tissue destruction
Antigen-specific T cells play a pivotal role in adaptive immune responses. However, they also contribute to the progression of a variety of diseases including autoimmune disorders, graft rejection and graft-versus-host disease (GVHD). Non-specific immune-ablation treatments compromise the ability of the host to respond to infection, whereas the selective rem
Blackwell Science Inc.
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7. Modification of ribosomal RNA by ribosome-inactivating proteins from plants.
We have surveyed 14 different toxic and nontoxic ribosome-inactivating proteins from plants for the ability to act on the RNA of the eucaryotic 60 S ribosomal subunit. All of these proteins act to introduce a specific modification into 26-28 S RNA which renders the RNA sensitive to cleavage by aniline. Sequence analysis of the 5'-termini of the fragments pro
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8. Acetylcholine in the orbitofrontal cortex is necessary for the acquisition of a socially transmitted food preference
The social transmission of food preference task (STFP) has been used to examine the involvement of the hippocampus in learning and memory for a natural odor-odor association. However, cortical involvement in STFP has not been extensively studied. The orbitofrontal cortex (OFC) is important in odor-guided learning, and cholinergic depletion of the entire neoc
Cold Spring Harbor Laboratory Press.
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9. Cognitive changes and modified processing of amyloid precursor protein in the cortical and hippocampal system after cholinergic synapse loss and muscarinic receptor activation
A number of in vitro studies have shown that activation of muscarinic receptors by cholinergic agonists stimulates the nonamyloidogenic, α-secretase-processing pathway of amyloid precursor protein (APP). To determine whether increased cholinergic neurotransmission can modify the APP processing in vivo, we administered a muscarinic receptor agonist (RS86) to
The National Academy of Sciences.
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10. Targeted ablation of cardiac sympathetic neurons reduces resting, reflex and exercise-induced sympathetic activation in conscious rats
Cholera toxin B subunit conjugated to saporin (SAP, a ribosomal inactivating protein that binds to and inactivates ribosomes) was injected in both stellate ganglia to evaluate the physiological response to targeted ablation of cardiac sympathetic neurons. Resting cardiac sympathetic activity (cardiac sympathetic tonus), exercise-induced sympathetic activity
American Physiological Society.
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11. Neural stem cells and cholinergic neurons: Regulation by immunolesion and treatment with mitogens, retinoic acid, and nerve growth factor
Degenerative diseases represent a severe problem because of the very limited repair capability of the nervous system. To test the potential of using stem cells in the adult central nervous system as “brain-marrow” for repair purposes, several issues need to be clarified. We are exploring the possibility of influencing, in vivo, proliferation, migrat
National Academy of Sciences.