Semicarbazide
Mostrando 1-12 de 33 artigos, teses e dissertações.
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1. Efficient Synthesis and Antimicrobial Activities of Long Alkyl Chain Trifluoromethyl-1H-pyrazol-1-(thio)carboxamides and Trifluoromethyl-1H-pyrazol-1-yl-thiazoles
The synthesis of 3-alkyl-5-trifluoromethyl-1H- pyrazole-1-carboxamides, 3-alkyl-5-trifluoromethyl-1H-pyrazole-1-thiocarboxamides, and 2-(3-alkyl-5-trifluoromethyl-1H-pyrazol-1-yl)-thiazoles derivatives are reported. [3 + 2] cyclocondensations for a series of long alkyl chain 1,1,1-trifluoro-4-methoxyalk-3-en-2-ones and semicarbazide or thiosemicarbazide were
J. Braz. Chem. Soc.. Publicado em: 2021-04
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2. Efeitos do contaminante alimentar semicarbazida na morfologia testicular de ratos Wistar jovens
O objectivo do presente trabalho foi avaliar os efeitos da semicarbazida na morfologia testicular de ratos Wistar jovens. Os animais foram tratados durante 30 dias com hidrocloreto de semicarbazida incorporado na dieta, nas concentrações de 0, 3 e 6g/kg. Os resultados obtidos revelaram uma diminuição estatisticamente significativa no diâmetro dos túbul
Arquivo Brasileiro de Medicina Veterinária e Zootecnia. Publicado em: 2012-06
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3. Efeitos da semicarbazida no esqueleto de ratos Wistar em crescimento
The effects of semicarbazide hydrochloride on skeletal tissues were evaluated using Wistar rats. In the animals submitted to the administration of semicarbazide, radiological examination showed bone and articular alterations with growth plates enlargement. Histological exams showed irregular patterns and proliferation of chondrocytes and excessive accumulati
Arquivo Brasileiro de Medicina Veterinária e Zootecnia. Publicado em: 2012-04
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4. Correlation between total nitrite/nitrate concentrations and monoamine oxidase (types A and B) and semicarbazide-sensitive amine oxidase enzymatic activities in human mesenteric arteries from non-diabetic and type 2 diabetic patients
The aim of this study was to determine the correlation between total nitrite/nitrate concentrations (NOx) and the kinetic parameters of monoamine oxidase enzymes (MAO-A and MAO-B) and semicarbazide-sensitive amine oxidase (SSAO) in human mesenteric arteries. Arteries were from non-diabetic and type 2 diabetic patients with sigmoid or rectum carcinoma for who
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-01
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5. Gabaergic mechanisms of anterior and ventromedial hypothalamic nuclei in the expression of freezing in response to a light-conditioned stimulus
The amygdala, dorsal periaqueductal gray (dPAG), and medial hypothalamus have long been recognized to comprise a neural system responsible for the generation and elaboration of unconditioned fear in the brain. This neural substrate is well known to be under tonic inhibitory control exerted by γ-aminobutyric acid (GABA) mechanisms. Some evidence also suggest
Psychology & Neuroscience. Publicado em: 2011
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6. Involvement of GABAergic mechanisms of the dorsal periaqueductal gray and inferior colliculus on unconditioned fear
The fact that the dorsal periaqueductal gray (dPAG) and inferior colliculus (IC), together with superior colliculus, medial hypothalamus and amygdala, constitute the brain aversion system has been well-established. Stepwise increases in the intensity of electrical stimulation of dPAG or IC cause freezing and escape responses, which are followed by a freezing
Psychology & Neuroscience. Publicado em: 2009-06
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7. SÍNTESE E CARACTERIZAÇÃO ESTRUTURAL DE PIRAZOLINIL-TOLIL-SULFONAS TRIALOMETIL SUBSTITUÍDAS DE INTERESSE ANTIMICROBIANO. / SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF TRIHALOMETHYL SUBSTITUTED PYRAZOLYNIL-TOLYLSULFONES OF ANTIMICROBIAL INTEREST.
The present research describes the use of b-alcoxyvynil trihalomethyl ketones [CX3C(O)CR2CR1R, where X= Cl, F; R= OMe, OEt; R1: H, Me, Ph, 4-MePh, 4-MeOPh, 4-BrPh, 4-ClPh, 4-FPh; R2= H, Ph] in the regiospecific synthesis of 16 new 3(4)-alkyl(aryl) substituted 5-trihalomethyl-5-hydroxy-4,5-dihydro-1H-1-tosylpyrazoles. These pyrazolines were obtained from the
Publicado em: 2006
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8. β-Alkoxyvinyl Halomethyl Ketones: Synthesis and application in obtaining of haloaryl enaminones, bis-haloarylenaminones, and 5-dichloromethyl-3-methyl-1H-pyrazoles. / β-Alcoxivinil Halometil Cetonas: Síntese e Aplicação na Obtenção de Haloaril enaminonas, Bis-haloarilenaminonas e 5- Diclorometil-3-metil-1H-pirazóis.
The synthesis of a series of β-enamines compounds [R2C(O)CH=C(R1)NR3R4, where R2 = CF3, CCl3, CHCl2; R3/R4 = H/Ph, H/4-F-C6H4, H/CH2Ph, H/CH2CH2OH, Me/Ph, Me/n-Bu, Et/ Et, -(CH2)4-, Me/Me] from the reaction of β-alkoxyvinyl halomethyl ketones with amines in solvent free conditions is reported. This reactional conditions showed the improvement in yi
Publicado em: 2005
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9. SYNTHESIS, REACTIVITY AND ANTIMICROBIAL ACTIVITY OF α-CHLORO β-ENAMINO ESTERS USING K-10 AND MICROWAVE IRRADIATION / SÍNTESE, REATIVIDADE E ATIVIDADE ANTIMICROBIANA DE β-ENAMINO ÉSTERES α-CLORADOS UTILIZANDO K-10 E IRRADIAÇÃO DE MICROONDAS
Enamino carbonylic compounds are important synthetic intermediates used in the synthesis of heterocycles and natural products. Our group of research has been dedicating much of our efforts to the development and implementation of simple and efficient methodologies to obtain β-enamino carbonylic compounds, mainly due to their functionality and ability to
Publicado em: 2005
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10. Neural organization of the mesencephalic system responsible for the freezing behavior. / Organização do sistema neural mesencefálico responsável pela resposta de congelamento.
Freezing to a context previously associated to footshock is attenuated by ventrolateral periaqueductal gray (vlPAG) lesion. Moreover, electrical stimulation or microinfusion of compounds that interfere with GABA neurotransmission in the dorsolateral periaqueductal gray (dlPAG) provoke freezing and escape. The present study examined the possibility of this fr
Publicado em: 2003
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11. Alterações da aorta em ratas portadoras de neoplasia
Cancer cachexia is a systemic disorder composed by physical wasting features and metabolic disturbance. Although skeletal muscle and fat tissue are the most affected structures, atrophy of heart, spleen, liver and kidney has also been described. Clinical and experimental data about alterations due to cachexia of the pre-existing host vessels are rare. The pu
Publicado em: 2000
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12. 13C High-Resolution Nuclear Magnetic Resonance Studies of Enzyme-Substrate Reactions at Equilibrium. Substrate Strain Studies of Chymotrypsin-N-Acetyltyrosine Semicarbazide Complexes
N-Acetyl-L-tyrosine semicarbazide is hydrolyzed by chymotrypsin (EC 3.4.21.1) to N-acetyl-L-tyrosine and semicarbazide. If a high concentration of semicarbazide is present, the equilibrium for the reaction can be shifted from hydrolysis to synthesis. Using N-acetyl-L-[13C]tyrosine enriched at the carboxyl carbon and high concentrations of semicarbazide hydro