Septin 7
Mostrando 1-12 de 12 artigos, teses e dissertações.
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1. Estudos estruturais e bioquímicos das septinas 7 e 9 humanas / Structural and biochemical studies of human septins 7 e 9
As proteínas pertencentes à família das septinas foram originalmente descobertas em 1971 em decorrencia de estudos genéticos em células mutantes. Essas proteínas encontradas em fungos e animais, mas não em plantas apresentam como principais características a presença de um domínio conservado de ligação aos nucleotídeos de guanina (GTP) e a forma
Publicado em: 2010
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2. Caracterização funcional e estrutural das septinas humanas 1, 6 e 8 / Functional and structural characterization of human septins 1, 6 and 8
Septins have a central domain which binds GTP (GTPase domain) and two other variable domains at their N- and C-termim Their principal characteristic is the ability to bind to other septins, thereby forming filaments. This is intimately related to their functions in cytokinesis, exocytosis, and apoptosis, among others. They are also directly or indirectly ass
Publicado em: 2010
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3. Estudos das interações da septina 4 humana / Study of Human Septin 4 interactions
Septinas são proteínas ligantes a GTP encontradas desde fungos até metazoários. A primeira função identificada para septinas foi o seu papel central na organização e dinâmica do septo de divisão de leveduras. Uma das características marcantes é que septinas se organizam em heterofilamentos de 7 a 9 nm de espessura que foram purificados de diverso
Publicado em: 2009
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4. Estudos estruturais da septina humana SEPT11 / STRUCTURAL STUDIES OF THE HUMAN SEPTIN SEPT11
Septinas são proteínas de ligação ao nucleotídeo de guanina (GTP). Foram inicialmente identificadas em fungos e atuam na fase final da divisão celular. Posteriormente, também verificaram que esta família de proteínas está presente em outros eucariotos com exceção de plantas. Septinas são purificadas de fungos Saccharomyces cerevisiae, Drosophila
Publicado em: 2008
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5. Bni5p, a Septin-Interacting Protein, Is Required for Normal Septin Function and Cytokinesis in Saccharomyces cerevisiae
In the budding yeast Saccharomyces cerevisiae, the Cdc3p, Cdc10p, Cdc11p, Cdc12p, and Sep7p/Shs1p septins assemble early in the cell cycle in a ring that marks the future cytokinetic site. The septins appear to be major structural components of a set of filaments at the mother-bud neck and function as a scaffold for recruiting proteins involved in cytokinesi
American Society for Microbiology.
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6. A Monitor for Bud Emergence in the Yeast Morphogenesis Checkpoint
Cell cycle transitions are subject to regulation by both external signals and internal checkpoints that monitor satisfactory progression of key cell cycle events. In budding yeast, the morphogenesis checkpoint arrests the cell cycle in response to perturbations that affect the actin cytoskeleton and bud formation. Herein, we identify a step in this check
The American Society for Cell Biology.
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7. Septin-Dependent Assembly of a Cell Cycle-Regulatory Module in Saccharomyces cerevisiae
Saccharomyces cerevisiae septin mutants have pleiotropic defects, which include the formation of abnormally elongated buds. This bud morphology results at least in part from a cell cycle delay imposed by the Cdc28p-inhibitory kinase Swe1p. Mutations in three other genes (GIN4, encoding a kinase related to the Schizosaccharomyces pombe mitotic inducer Nim1p;
American Society for Microbiology.
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8. Hsl7 Localizes to a Septin Ring and Serves as an Adapter in a Regulatory Pathway That Relieves Tyrosine Phosphorylation of Cdc28 Protein Kinase in Saccharomyces cerevisiae
Successful mitosis requires faithful DNA replication, spindle assembly, chromosome segregation, and cell division. In the budding yeast Saccharomyces cerevisiae, the G2-to-M transition requires activation of Clb-bound forms of the protein kinase, Cdc28. These complexes are held in an inactive state via phosphorylation of Tyr19 in the ATP-binding loop of Cdc2
American Society for Microbiology.
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9. MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25)
MLL (ALL1, Htrx, HRX), which is located on chromosome band 11q23, frequently is rearranged in patients with therapy-related acute myeloid leukemia who previously were treated with DNA topoisomerase II inhibitors. In this study, we have identified a fusion partner of MLL in a 10-year-old female who developed therapy-related acute myeloid leukemia 17 months af
The National Academy of Sciences.
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10. Dynamic Localization of the Swe1 Regulator Hsl7 During the Saccharomyces cerevisiae Cell Cycle
In Saccharomyces cerevisiae, entry into mitosis requires activation of the cyclin-dependent kinase Cdc28 in its cyclin B (Clb)-associated form. Clb-bound Cdc28 is susceptible to inhibitory tyrosine phosphorylation by Swe1 protein kinase. Swe1 is itself negatively regulated by Hsl1, a Nim1-related protein kinase, and by Hsl7, a presumptive protein-argini
The American Society for Cell Biology.
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11. A Bni4-Glc7 Phosphatase Complex That Recruits Chitin Synthase to the Site of Bud EmergenceV⃞
Bni4 is a scaffold protein in the yeast Saccharomyces cerevisiae that tethers chitin synthase III to the bud neck by interacting with septin neck filaments and with Chs4, a regulatory subunit of chitin synthase III. We show herein that Bni4 is also a limiting determinant for the targeting of the type 1 serine/threonine phosphatase (Glc7) to the bud neck. Yea
The American Society for Cell Biology.
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12. Genetic analysis of the bipolar pattern of bud site selection in the yeast Saccharomyces cerevisiae.
Previous analysis of the bipolar budding pattern of Saccharomyces cerevisiae has suggested that it depends on persistent positional signals that mark the region of the division site and the tip of the distal pole on a newborn daughter cell, as well as each previous division site on a mother cell. In an attempt to identify genes encoding components of these s