Shikimate Pathway
Mostrando 1-12 de 60 artigos, teses e dissertações.
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1. Biosynthetic Insights into p-Hydroxybenzoic Acid-Derived Benzopyrans in Piper gaudichaudianum
Piper gaudichaudianum Kunth (Piperaceae) accumulates gaudichaudianic acid, a prenylated benzopyran, as its major component. Interestingly, this trypanocidal compound occurs as a racemic mixture. Herein, transcriptomic investigations of Piper gaudichaudianum using the RNA-seq approach are reported, and from the analysis of the transcripts expressed it was pos
J. Braz. Chem. Soc.. Publicado em: 2018-05
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2. Biossíntese de vitamina E nos estágios intraeritrocitários de P. falciparum. / Vitamin E biosynthesis in intraerythrocytic stages of Plasmodium falciparum.
The study of isoprenoid biosynthesis in Plasmodium falciparum by 2C-methyl-D-erythritol-4-phosphate pathway (MEP) it is presented as a therapeutic target once that it is absent in humans. It was found in intraerythrocytic stages of P. falciparum the biosynthesis of isoprenoids by the MEP pathway. The shikimate and MEP pathways are the precursors of biosynthe
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/02/2011
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3. Bioassay for detection of transgenic soybean seeds tolerant to glyphosate.
Glyphosate is a systemic, nonselective, postemergence herbicide that inhibits growth of both weeds and crop plants. Once inside the plant, glyphosate interferes with biosynthesis of aromatic amino acids phenylalanine, tyrosine, and tryptophan, by inhibiting the activity of 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS), a key enzyme of the shikimate pat
Pesquisa Agropecuária Brasileira. Publicado em: 2011
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4. The Mycobacterium tuberculosis Rv2540c DNA sequence encodes a bifunctional chorismate synthase
Background: The emergence of multi- and extensively-drug resistant Mycobacterium tuberculosis strains has created an urgent need for new agents to treat tuberculosis (TB). The enzymes of shikimate pathway are attractive targets to the development of antitubercular agents because it is essential for M. tuberculosis and is absent from humans. Chorismate syntha
Publicado em: 2010
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5. O estudo da enzima deidroquinato sintase de Mycobacterium tuberculosis H37Rv como alvo para o desenvolvimento de fármacos antituberculose
Apesar da incidência per capita da tuberculose (TB) ter se mantido estável em 2005, o número de novos casos que surgem a cada ano continua a aumentar no mundo todo. De acordo com a Organização Mundial de Saúde, foram estimados 9,4 milhões de novos casos de TB em 2008, dos quais 1,4 milhões eram HIV - positivos, e com 1,8 milhões de mortes - o equiva
Publicado em: 2010
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6. Estudo Teórico de Mecanismos para a Etapa de Eliminação da Síntese do 5-Enolpiruvilchiquimato-3-Fosfato (EPSP) catalisada pela EPSP Sintase de Oryza sativa.
In the sixth step of the shikimate pathway, catalyzed by 5-enolpyruvylshikimate-3- phosphate synthase (EPSPS), phosphoenolpyruvyl (PEP) reacts with shikimate-3-phosphate (S3P) to produce 5-enolpyruvylshikimate-3-phosphate (EPSP) and inorganic phosphate. Because the shikimate pathway is absent in animals, but is essential for plants and microrganisms, EPSPS i
Publicado em: 2008
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7. Antioxidant enzymes response to glyhosate herbicide application in transgenic and nottrangenic soybean "varieties" / Resposta de enzimas antioxidantes à aplicação do herbicida glifosato em variedades de soja transgênica e não transgênica
Herbicides are applied in cultures with the objective to eliminate weeds, but the effects over the plants sometimes are not perceptible or are not widely considered. Plants under stress conditions can react to the elicitor with oxidative manifestations where reactive oxygen species (ROS) are generating. Glyphosate acts as a competitive inhibitor of enolpiruv
Publicado em: 2007
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8. Targeting the Shikimate Pathway in the Malaria Parasite Plasmodium falciparum
The shikimate pathway presents an attractive target for malaria chemotherapy. Three shikimic acid analogs exhibited different effects on Plasmodium falciparum growth. (6R)-6-Fluoro-shikimate and (6S)-6-fluoro-shikimate inhibited growth (50% inhibitory concentrations, 1.5 × 10−5 and 2.7 × 10−4 M, respectively), whereas 2-fluoro-shikimate had no effect.
American Society for Microbiology.
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9. Temporally distinct accumulation of transcripts encoding enzymes of the prechorismate pathway in elicitor-treated, cultured tomato cells.
The accumulation of phenylalanine-derived phenolic compounds is a well-known element of a plant's defense in response to pathogen attack. Phenylalanine, as well as the other two aromatic amino acids, tyrosine and tryptophan, is synthesized by way of the shikimate pathway. The first seven steps of the shikimate pathway (the prechorismate pathway) are common f
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10. The Site of the Inhibition of the Shikimate Pathway by Glyphosate: II. INTERFERENCE OF GLYPHOSATE WITH CHORISMATE FORMATION IN VIVO AND IN VITRO1
In the presence of the nonselective herbicide glyphosate (N-[phosphonomethyl]glycine), buckwheat (Fagopyrum esculentum Moench) hypocotyls and cultured cells of Galium mollugo L. accumulate an organic acid, which was identified as shikimate by mass-spectroscopy of its methyl ester. After growth in 0.5 millimolar glyphosate for 10 days, G. mollugo cells contai
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11. The Site of the Inhibition of the Shikimate Pathway by Glyphosate: I. INHIBITION BY GLYPHOSATE OF PHENYLPROPANOID SYNTHESIS IN BUCKWHEAT (FAGOPYRUM ESCULENTUM MOENCH) 1, 2
The nonselective herbicide glyphosate (n-[phosphonomethyl]glycine) inhibited the light-induced accumulation of phenylpropanoid substances (chlorogenic acid, procyanidin, rutin, anthocyanin) in etiolated buckwheat hypocotyls 90% at 1 millimolar. Structurally related compounds, such as n,n-bis[phosphonomethyl]glycine, aminomethylphosphonate, methylglycine, and
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12. The Shikimate Pathway: Early Steps in the Biosynthesis of Aromatic Compounds.