Skeletal Muscle Transplantation
Mostrando 1-12 de 21 artigos, teses e dissertações.
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1. Efeito da terapia com células-tronco musculares e células-tronco mesenquimais na regeneração do músculo esquelético: modulação por ácido oléico. / Effect of muscle stem cells and mesenchymal stem cells transplantation on skeletal muscle regeneration: modulatory effect of oleic acid.
O objetivo do presente trabalho foi investigar alterações na composição de ácidos graxos durante a diferenciação de células-tronco musculares (CTmusc) e seu possível envolvimento na miogênese. Aumento no conteúdo de ácido oléico foi observado. Quando as CTmusc foram tratadas com esse ácido graxo, a miogênese foi acelerada através da estimula�
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/06/2012
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2. O uso de células-tronco adultas em modelos experimentais de crises convulsivas. / The use of adult stem cells in experimental models of seizures.
In Brazil, it is estimated that epilepsy affects from 2% of the population, about three million people at different ages and social classes. The use of antiepileptic drugs is the most common form of seizure control, although about 50- 70% of patients with epilepsy are refractory to medication. Because of difficulties in finding effective treatments, it is cr
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/05/2010
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3. Avaliação do padrão de degeneração e regeneração muscular em diferentes modelos murinos para distrofias musculares progressivas / Study of degeneration and regeneration pathways, in mice models for muscular dystrophies
The muscular dystrophies are a heterogeneous group of genetic diseases characterized by progressive and irreversible degeneration of skeletal muscles. Muscle weakness is the consequence of an imbalance between successive cycles of degeneration and regeneration, with further replacement of the degraded muscle fibers by adipose and connective tissues. Several
Publicado em: 2009
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4. Efeito da utilização de plasma rico em plaquetas na osteointegração dos enxertos ósseos homólogos criopreservados: estudo histomorfométrico em coelhos / Effects of platelet rich plasma in osteointegration of cryopreserved homologous bone grafts: histomorphometric study in rabbits
Bone loss, in some segments of the muscle-skeleton system, are of great concern in the fields of Orthopedics and Traumatology. There are several options of treatment by means of bone grafts and growth factors. In this study we evaluate the effect of platelet rich plasma (PRP) in the initial phase of osteointegration of cryopreserved (- 80 °C) homologous bon
Publicado em: 2007
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5. Transplanted hematopoietic stem cells demonstrate impaired sarcoglycan expression after engraftment into cardiac and skeletal muscle
Pluripotent bone marrow–derived side population (BM-SP) stem cells have been shown to repopulate the hematopoietic system and to contribute to skeletal and cardiac muscle regeneration after transplantation. We tested BM-SP cells for their ability to regenerate heart and skeletal muscle using a model of cardiomyopathy and muscular dystrophy that lacks δ-sa
American Society for Clinical Investigation.
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6. Genetic correction of dystrophin deficiency and skeletal muscle remodeling in adult MDX mouse via transplantation of retroviral producer cells.
Duchenne muscular dystrophy (DMD) is an X-linked, lethal disease caused by mutations of the dystrophin gene. No effective therapy is available, but dystrophin gene transfer to skeletal muscle has been proposed as a treatment for DMD. We have developed a strategy for efficient in vivo gene transfer of dystrophin cDNA into regenerating skeletal muscle. Retrovi
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7. Long-term persistence of donor nuclei in a Duchenne muscular dystrophy patient receiving bone marrow transplantation
Duchenne muscular dystrophy (DMD) is a severe progressive muscle-wasting disorder caused by mutations in the dystrophin gene. Studies have shown that bone marrow cells transplanted into lethally irradiated mdx mice, the mouse model of DMD, can become part of skeletal muscle myofibers. Whether human marrow cells also have this ability is unknown. Here we repo
American Society for Clinical Investigation.
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8. Islet transplantation under the kidney capsule fully corrects the impaired skeletal muscle glucose transport system of streptozocin diabetic rats.
Chronic insulin therapy improves but does not restore impaired insulin-mediated muscle glucose uptake in human diabetes or muscle glucose uptake, transport, and transporter translocation in streptozocin diabetic rats. To determine whether this inability is due to inadequate insulin replacement, we studied fasted streptozocin-induced diabetic Lewis rats eithe
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9. Spontaneous and evoked intracellular calcium transients in donor-derived myocytes following intracardiac myoblast transplantation
Skeletal myoblast transplantation is a potential treatment for congestive heart failure. To study the functional activity of both donor and host myocytes following transplantation, skeletal myoblasts expressing an enhanced green fluorescent protein (EGFP) transgene were transplanted into hearts of nontransgenic recipients, and changes in intracellular calciu
American Society for Clinical Investigation.
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10. Skeletal myoblast transplantation for repair of myocardial necrosis.
Myocardial infarcts heal by scarring because myocardium cannot regenerate. To determine if skeletal myoblasts could establish new contractile tissue, hearts of adult inbred rats were injured by freeze-thaw, and 3-4.5 x 10(6) neonatal skeletal muscle cells were transplanted immediately thereafter. At 1 d the graft cells were proliferating and did not express
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11. Adhesion and incorporation of lacZ-transduced endothelial cells into the intact capillary wall in the rat.
Use of the capillary bed of skeletal muscle as an in vivo recipient site to transplant autologous endothelial cells that have undergone gene transfer ex vivo has considerable potential as a technique of somatic gene therapy. Here we document a previously unrecognized capacity of endothelial cells to adhere and incorporate spontaneously into confluent endothe
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12. Systemic delivery of human microdystrophin to regenerating mouse dystrophic muscle by muscle progenitor cells
Cell-based therapy for Duchenne muscular dystrophy patients and mdx mice has proven to be a safe but ineffective form of treatment. Recently, a group of cells called muscle side population (SP) cells have been isolated based on their ability to efflux the DNA-binding dye Hoechst. To understand the potential of skeletal muscle SP cells to serve as precursors
National Academy of Sciences.