Skeletogenesis
Mostrando 1-12 de 16 artigos, teses e dissertações.
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1. Skeletogenesis of the cranium of the embryos of Caiman yacare (DAUDIN, 1802) (CROCODYLIA, ALLIGATORIDAE) / Desenvolvimento do esqueleto em embriões de Caiman yacare (Daudin 1802) (Crocodylia, Alligatoridae)
O crânio representa uma estrutura única para os vertebrados, e sua anatomia atual é o resultado de milhares de anos de evolução, sendo assim o foco principal de estudos morfológicos e sistemáticos. Diante a importância de seu estudo pormenorizado, objetivou-se esclarecer os processos de formação do crânio em embriões de Caiman yacare. Coletaram-s
Publicado em: 2010
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2. HOX gene analysis in the osteogenic differentiation of human mesenchymal stem cells
Human bone marrow-derived mesenchymal stem cells (hMSCs) have the capacity to differentiate into osteoblasts during osteogenesis. Several studies attempted to identify osteogenesis-related genes in hMSCs. Although HOX genes are known to play a pivotal role in skeletogenesis, their function in the osteogenesis of hMSCs has not yet been investigated in deta
Genetics and Molecular Biology. Publicado em: 19/11/2008
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3. Biologia celular da esqueletogênese e processos de mineralização em Holothuroidea (Echinodermata) / Cellular biology of skeletogenesis and mineralization processes in Holothuroidea (Echinodermata)
Biomineralização é o processo em que organismos precipitam materiais sólidos para a formação de estruturas esqueléticas. Nos Echinodermata o esqueleto é composto por CaCO3, com uma organização e morfologia variável entre as classes do filo. Nos Echinoidea, onde o processo de calcificação tem sido mais estudado, os sítios de formação do esquel
Publicado em: 2008
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4. Current Advances in Skeletogenesis
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5. Mammalian Twisted Gastrulation Is Essential for Skeleto-Lymphogenesis
Dorsoventral patterning depends on the local concentrations of the morphogens. Twisted gastrulation (TSG) regulates the extracellular availability of a mesoderm inducer, bone morphogenetic protein 4 (BMP-4). However, TSG function in vivo is still unclear. We isolated a TSG cDNA as a secreted molecule from the mouse aorta-gonad-mesonephros region. Here we sho
American Society for Microbiology.
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6. The integumentary skeleton of tetrapods: origin, evolution, and development
Although often overlooked, the integument of many tetrapods is reinforced by a morphologically and structurally diverse assemblage of skeletal elements. These elements are widely understood to be derivatives of the once all-encompassing dermal skeleton of stem-gnathostomes but most details of their evolution and development remain confused and uncertain. Her
Blackwell Science Inc.
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7. Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development
Vertebrate skeletogenesis requires a well-coordinated transition from chondrogenesis to osteogenesis. Hypertrophic chondrocytes in the growth plate play a pivotal role in this transition. Parathyroid hormone–related peptide (PTHrP), synthesized in the periarticular growth plate, regulates the site at which hypertrophy occurs. By comparing PTH/PTHrP recepto
American Society for Clinical Investigation.
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8. β1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis
β1 integrins are highly expressed on chondrocytes, where they mediate adhesion to cartilage matrix proteins. To assess the functions of β1 integrin during skeletogenesis, we inactivated the β1 integrin gene in chondrocytes. We show here that these mutant mice develop a chondrodysplasia of various severity. β1-deficient chondrocytes had an abnormal shape
Cold Spring Harbor Laboratory Press.
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9. Abnormal ambient glucose levels inhibit proteoglycan core protein gene expression and reduce proteoglycan accumulation during chondrogenesis: possible mechanism for teratogenic effects of maternal diabetes.
Using a tissue culture system based on a nearly pure population of avian precartilage mesenchymal cells, we have found that ambient glucose levels as little as 50% lower, or 100% higher, than normally present in embryonic sera are deleterious to cartilage development, as measured by the accumulation of highly sulfated proteoglycan and the corresponding carti
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10. Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities
Pax genes have been shown to play important roles in mammalian development and organogenesis. Pax9, a member of this transcription factor family, is expressed in somites, pharyngeal pouches, mesenchyme involved in craniofacial, tooth, and limb development, as well as other sites during mouse embryogenesis. To analyze its function in vivo, we generated Pax9 d
Cold Spring Harbor Laboratory Press.
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11. Developmental gene regulatory network architecture across 500 million years of echinoderm evolution
Evolutionary change in morphological features must depend on architectural reorganization of developmental gene regulatory networks (GRNs), just as true conservation of morphological features must imply retention of ancestral developmental GRN features. Key elements of the provisional GRN for embryonic endomesoderm development in the sea urchin are here comp
National Academy of Sciences.
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12. Stimulatory G protein directly regulates hypertrophic differentiation of growth plate cartilage in vivo
Stimulatory heterotrimeric G protein (Gs) transduces signals from various cell-surface receptors to adenylyl cyclases, which generate cAMP. The α subunit of Gs (Gsα) is encoded by GNAS (Gnas in mice), and heterozygous Gsα inactivating mutations lead to Albright hereditary osteodystrophy. The in vivo role of Gsα in skeletogenesis is largely unknown, becau
National Academy of Sciences.