Specific Proliferative Response
Mostrando 1-12 de 366 artigos, teses e dissertações.
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1. An experimental protocol for the establishment of dogs with long-term cellular immune reactions to Leishmania antigens
Domestic dogs are considered to be the main reservoirs of zoonotic visceral leishmaniasis. In this work, we evaluated a protocol to induce Leishmania infantum/Leishmania chagasi-specific cellular and humoral immune responses in dogs, which consisted of two injections of Leishmania promastigote lysate followed by a subcutaneous inoculation of viable promastig
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-03
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2. Immunodiagnosis potential of M. tuberculosis CFP-10 for active tuberculosis / Anáilise do potencial diagnóstico do anígeno CFP-10 expresso pelo M. tuberculosis.
The use of specific antigens of M. tuberculosis is extremely important for early diagnosis of tuberculosis and to control the spread of mycobacteria in the population. The CFP-10 is an antigen that is present in M. tuberculosis, but is absent in M. bovis of BCG and environmental mycobacteria. So, the objective of this study was to determine whether the immun
Publicado em: 2010
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3. Humoral and cellular immune responses to Blomia tropicalis and concanavalin A-binding fractions in atopic patients
Blomia tropicalis, Dermatophagoides pteronyssinus and D. farinae are prevalent house dust mites. Concanavalin A-binding components derived from B. tropicalis (Bt-ConA extract) are highly immunogenic in allergic diseases. The aim of the present study was to evaluate the humoral and cellular immune responses to B. tropicalis in mite-sensitized patients. A tota
Brazilian Journal of Medical and Biological Research. Publicado em: 2008-09
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4. Analysis of T-and B-cell memory after untreated and drug treated blood-stage Plasmodium chabaudi AS malaria. / Análise dos compartimentos de linfócitos T e B de memória em animais tratados e não tratados com cloroquina durante a infecção pelo Plasmodium chabaudi AS.
One of the main characteristics of malaria is the intense policlonal activation of splenic T and B lymphocytes induced by the parasite and the consequent elimination, through apoptosis, of part of these cells. However, the limited exposure to the bloodstage malaria seems to induce a prominent cellular immunity, associated with the protection of T lymphocytes
Publicado em: 2008
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5. Molecular aspects involved in the apoptosis of mononuclear cells of patients with paracoccidioidomycosis. / Aspectos moleculares envolvidos na apoptose de células mononucleares em pacientes com paracoccidioidomicose.
The T-cell hypoproliferative reactivity observed in the immune response to P. brasiliensis antigens of patients with active paracoccidioidomycosis probably contributes to the failure of the host in controlling the infection, leading to a disseminated disease. It is, however, largely reversible with treatment in most patients. The mechanisms leading to this h
Publicado em: 2008
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6. Resposta imune humoral e celular a Blomia tropicalis e sua fração ligante de Concanavalina A em pacientes atópicos
Blomia tropicalis (Bt), Dermatophagoides pteronyssinus (Dp) and D. farinae (Df) are the prevalent house dust mites (HDMs). Concanavalin A-binding components derived from B. tropicalis (Bt-ConA extract) have shown to be highly immunogenic in allergic diseases. This study aimed to evaluate the humoral and cellular immune responses to B. tropicalis in sensitize
Publicado em: 2007
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7. Resposta imune humoral e celular a Blomia tropicalis e sua fraÃÃo ligante de Concanavalina A em pacientes atÃpicos
Blomia tropicalis (Bt), Dermatophagoides pteronyssinus (Dp) and D. farinae (Df) are the prevalent house dust mites (HDMs). Concanavalin A-binding components derived from B. tropicalis (Bt-ConA extract) have shown to be highly immunogenic in allergic diseases. This study aimed to evaluate the humoral and cellular immune responses to B. tropicalis in sensitize
Publicado em: 2007
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8. Cissampelos sympodialis Eichl. (Menispermaceae) inhibits anaphylactic shock reaction in murine allergic model
The murine model of OVA-induced immediate allergic reaction was used to evaluate the effectiveness of intraperitoneal sub-acute treatment with the leaf hydroalcoholic extract of Cissampelos sympodialis (AFL) in the anaphylactic shock reaction, IgE production and the background proliferative response. BALB/c mice treated with AFL ranging from 200 to 400 mg/kg
Revista Brasileira de Farmacognosia. Publicado em: 2005-12
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9. Atrofia timica na paracoccidioidomicose experimental : influencia da virulencia fungica, da linhagem murina e de citocinas pro-inflamatorias / Thymic atrophy during experimental paracoccidioidomycosis : influence of fungal virulence, murine strain and pro-inflammatory cytokines
Thymus is the site of T cells maturation that orchestrates specific immune response following antigen recognition. In spite of this, it can be a target during many infectious diseases. Paracoccidioides brasiliensis, the etiological agent of paracoccidioidomycosis, is able to invade the thymus inducing atrophy in experimental models. In this study, it was ana
Publicado em: 2005
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10. Efeito citotóxico causado por emulsão lipídica contendo 7-cetocolesterol (OxLE) em cultura de células tumorais / Cytotoxic effects caused by 7-ketocholesterol-containing emulsion (OXLE) in tumor cells in culture
Oxysterols are oxygenated derivatives of cholesterol that may be formed by autoxidation or by action of specific enzymes. They exhibit a number of biologic activities including inhibition of cellular proliferation and cytotoxicity. Among oxysterols, 7-ketocholesterol (7-KC), that differs form cholesterol by a functional ketone group at C7, is known to induce
Publicado em: 2004
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11. Study of the safety, immunogenicity and efficacy of attenuated and killed Leishmania (Leishmania) major vaccines in a rhesus monkey (Macaca mulatta) model of the human disease
We have compared the efficacy of two Leishmania (Leishmania) major vaccines, one genetically attenuated (DHFR-TS deficient organisms), the other inactivated [autoclaved promastigotes (ALM) with bacillus Calmete-Guérin (BCG)], in protecting rhesus macaques (Macaca mulatta) against infection with virulent L. (L.) major. Positive antigen-specific recall prolif
Memórias do Instituto Oswaldo Cruz. Publicado em: 2002-10
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12. Extracts of Ascaris suum egg and adult worm share similar immunosuppressive properties
Adult Ascaris suum body extract (Asc) prepared from male and female worms (with stored eggs) down-regulates the specific immune response of DBA/2 mice to ovalbumin (OA) and preferentially stimulates a Th2 response to its own components, which is responsible for the suppression of the OA-specific Th1 response. Here, we investigated the participation of solubl
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-01