Sphingomyelinases D
Mostrando 1-3 de 3 artigos, teses e dissertações.
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1. Estudo do potencial neutralizante do soro equino anti-Esfingomielinases D recombinantes, sobre as ações tóxicas dos venenos das aranhas Loxosceles. / Study of the neutralization potential of the anti-recombinant Sphingomyelinases D serum, on the toxic effects of Loxosceles spider venoms.
Os envenenamentos por aranhas das espécies L. laeta, L. intermedia e L. gaucho, podem causar dermonecrose e efeitos sistêmicos. O principal componente tóxico do veneno destas apresenta atividade de esfingomielinase D (SMase D). O objetivo do presente estudo foi comparar o potencial neutralizante do novo soro anti-SMases D recombinantes e do soro anti-Arac
Publicado em: 2007
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2. Fas-induced apoptosis of T cells occurs independently of ceramide generation
The Fas receptor is one of a number of important physiological inducers of programmed cell death (apoptosis). Current models for regulation of this process involve rapid conversion of sphingomyelin to ceramide by cellular sphingomyelinases. Induced changes in cellular levels of such sphingosine-based ceramides are normally extrapolated from measurements of s
The National Academy of Sciences of the USA.
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3. Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal.
The early signals generated following cross-linking of Fas/APO-1, a transmembrane receptor whose engagement by ligand results in apoptosis induction, were investigated in human HuT78 lymphoma cells. Fas/APO-1 cross-linking by mAbs resulted in membrane sphingomyelin hydrolysis and ceramide generation by the action of both neutral and acidic sphingomyelinases.