Sphingosine 1 Phosphate
Mostrando 1-12 de 69 artigos, teses e dissertações.
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1. Expression of Sphingosine-1-phosphate (S1P) on the cerebral vasospasm after subarachnoid hemorrhage in rabbits
PURPOSE: To demonstrate the relationship between of sphingosine-1-phosphate (S1P) expression and subarachnoid hemorrhage (SAH). METHODS: The basilar arteries from a "double-hemorrhage" rabbit model of SAH were used to investigate the relation between S1P expression and SAH. Various symptoms, including blood clots, basilar artery cross-sectional area, and S
Acta Cir. Bras.. Publicado em: 2015-10
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2. CULTIVO IN SITU DE FOLÍCULOS OVARIANOS PRÉ-ANTRAIS DE CABRAS COM ESFINGOSINA (S1P) E FATOR INIBIDOR DA LEUCEMIA (LIF). / CULTURE IN SITU OF OVARIAN PREANTRAL FOLLICLE WITH SPHINGOSINE 1-PHOSPHATE (S1P) AND LEUKEMIA INHIBITORY FACTOR (LIF)
The manipulation of oocytes enclosed in follicles Ovarian Pre-Antral, allows increasing the reproductive potential of females from the isolation and cultivation. The follicular viability can be affected negatively correlated with age, malnutrition, exposure to radio or chemotherapy and health conditions. The alternatives are to use these research for develop
Publicado em: 2011
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3. Heterogeneidade e mecanismos moleculares da atividade anti-apoptótica das subfrações de HDL em células endoteliais humanas / Heterogeneity and molecular mechanisms of anti-apoptotic activity of high-density lipoprotein (HDL) subfractions on endothelial cells
Introdução: A lipoproteína de baixa densidade (LDL) e suas formas oxidadas (LDLox) possuem múltiplas propriedades aterogênicas, atuando na deposição de colesterol, indução e manutenção da inflamação, disfunção endotelial, surgimento de células espumosas na parede arterial e conseqüente formação da placa de ateroma. Adicionalmente, LDLox in
Publicado em: 2007
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4. Sphingosine protects aging hearts from ischemia/reperfusion injury: Superiority to sphingosine 1-phosphate and ischemic pre- and post-conditioning
Aging hearts are known to have diminished capacity to be protected against reoxygenation ischemia/reperfusion (IR) injury provided by various cardioprotective regimens. In search of a more successful regimen, we have studied the response of aged hearts to preconditioning (PC) and postconditioning (POST) elicited by sphingosine or sphingosine 1-phosphate trea
Landes Bioscience.
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5. Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation
Sphingosine kinase 1 is an agonist-activated signalling enzyme that catalyses the formation of sphingosine 1-phosphate, a lipid second messenger that has been implicated in a number of agonist-driven cellular responses, including stimulation of cell proliferation, inhibition of apoptosis and expression of inflammatory molecules. Although agonist-induced sti
Oxford University Press.
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6. Early Activation of Sphingosine Kinase in Mast Cells and Recruitment to FcɛRI Are Mediated by Its Interaction with Lyn Kinase
Sphingosine kinase has been recognized as an essential signaling molecule that mediates the intracellular conversion of sphingosine to sphingosine-1-phosphate. In mast cells, induction of sphingosine kinase and generation of sphingosine-1-phosphate have been linked to the initial rise in Ca2+, released from internal stores, and to degranulation. These events
American Society for Microbiology.
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7. Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-β-stimulated collagen production by cardiac fibroblasts
Oxford University Press.
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8. Sphingosine: a mediator of acute renal tubular injury and subsequent cytoresistance.
The goal of this study was to determine whether sphingosine and ceramide, second messengers derived from sphingolipid breakdown, alter kidney proximal tubular cell viability and their adaptive responses to further damage. Adult human kidney proximal tubular (HK-2) cells were cultured for 0-20 hr in the presence or absence of sphingosine, sphingosine metaboli
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9. Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity[S]
Studies in skeletal muscle demonstrate that elevation of plasma FFAs increases the sphingolipid ceramide. We aimed to determine the impact of FFA oversupply on total sphingolipid profiles in a skeletal muscle model. C2C12 myotubes were treated with palmitate (PAL). Lipidomics analysis revealed pleiotropic effects of PAL on cell sphingolipids not limited to c
The American Society for Biochemistry and Molecular Biology.
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10. Sphingosine-1-phosphate and modulation of vascular tone
Sphingosine-1-phosphate (S1P) is a phosphorylated product of sphingosine, the core structure of the class of lipids termed sphingolipids. S1P is a naturally occurring lipid metabolite, and usually is present at a concentration of a few 100 nanomolar in human sera. S1P has been found to exert a diverse set of physiological and pathophysiological responses in
Oxford University Press.
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11. Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death
Sphingosine and sphingosine-1-phosphate (SPP) are interconvertible sphingolipid metabolites with opposing effects on cell growth and apoptosis. Based on sequence homology with LBP1, a lipid phosphohydrolase that regulates the levels of phosphorylated sphingoid bases in yeast, we report here the cloning, identification, and characterization of a mammalian SPP
The National Academy of Sciences.
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12. Regulation of immunity by lysosphingolipids and their G protein–coupled receptors
T and B lymphocytes, as well as endothelial cells, express distinctive profiles of G protein–coupled receptors for sphingosine 1–phosphate, which is a major regulator of T cell development, B and T cell recirculation, tissue homing patterns, and chemotactic responses to chemokines. The capacity of drugs that act on type 1 sphingosine 1–phosphate recept
American Society for Clinical Investigation.