Spontaneously Hypertensive Rat
Mostrando 1-12 de 72 artigos, teses e dissertações.
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1. Is the Wistar Rat a more Suitable Normotensive Control for SHR to Test Blood Pressure and Cardiac Structure and Function?
Abstract Background: There are divergences in the literature regarding the experimental model (Wistar-WIS or Wistar Kyoto-WKY) to be used as a Spontaneously Hypertensive Rat (SHR) control. The characterization of these models in terms of cardiovascular parameters provides researchers with important tools at the time of selection and application in scientifi
International Journal of Cardiovascular Sciences. Publicado em: 2022
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2. Cerebral perfusion evaluation in animal models of hypertension using arterial spin labeling / Avaliação da perfusão sanguínea cerebral em modelos animais de hipertensão utilizando Arterial Spin Labeling
A hipertensão arterial é uma doença que aflinge mais de um quarto da população adulta mundial e mais da metade da população idosa. Ela é o principal fator de risco para doenças cerebrovasculares e o segundo fator de risco, após idade, para os acidentes vasculares cerebrais (AVC) hemorrágico e isquêmico. É também a principal causa de declínio c
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/09/2011
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3. Morphometric analysis of the phrenic nerve in male and female Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR)
Ventilatory differences between rat strains and genders have been described but the morphology of the phrenic nerve has not been investigated in spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats. A descriptive and morphometric study of the phrenic nerves of male (N = 8) and female (N = 9) SHR, and male (N = 5) and female (N = 6) WKY i
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-06
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4. Efeito do treinamento físico de natação sobre a resposta vasomotora arterial em ratos espontaneamente hipertensos: papel das espécies reativas de oxigênio e de nitrogênio / Effect of swimming training on the arterial vasomotor function in spontaneously hypertensive rats (SHR): role of reactive oxygen and nitrogen species
Estudos demonstram o envolvimento do superóxido vascular (O-2) na hipertensão arterial, associado à menor vasodilatação, decorrente da redução na biodisponibilidade de óxido nitrico (NO). O treinamento físico (TF) aeróbio tem sido mostrado eficiente em diminuir a pressão arterial em hipertensos, associado a melhora da função endotelial. Entretan
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/12/2010
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5. Ovariectomy does not affect the cardiac sympathovagal balance of female SHR but estradiol does
The low incidence of cardiovascular diseases, including hypertension, in premenopausal women has led to the conclusion that ovarian hormones may have a protective effect on the cardiovascular system. We evaluated the effects of ovariectomy and/or estradiol on sympathovagal balance and heart rate variability (HRV) in female spontaneously hypertensive rats (SH
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-10
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6. Structural properties of lipid reconstructs and lipid composition of normotensive and hypertensive rat vascular smooth muscle cell membranes
Multiple cell membrane alterations have been reported to be the cause of various forms of hypertension. The present study focuses on the lipid portion of the membranes, characterizing the microviscosity of membranes reconstituted with lipids extracted from the aorta and mesenteric arteries of spontaneously hypertensive (SHR) and normotensive control rat stra
Brazilian Journal of Medical and Biological Research. Publicado em: 31/07/2009
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7. In vitro and in vivo assessment of the antihypertensive activity of comercial hydrolysates from various protein sources. / Avaliação in vitro e in vivo da atividade anti-hipertensiva de hidrolisados comerciais de diversas fontes proteicas.
Angiotensin converting enzyme (ACE) inhibitory peptides present in foods have motivated the interest of many researchers, since there is evidence that the ingestion of these peptides, could aid in the prevention and in the non-medication treatment of hypertension. The anti-hypertensive activity of the peptides has been mainly assessed in relation to their ca
Publicado em: 2006
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8. Comparison of voluntary ethanol intake by two pairs of rat lines used as genetic models of anxiety
The relationship between anxiety-related behaviors and voluntary ethanol intake was examined in two pairs of rat lines by the oral ethanol self-administration procedure. Floripa high (H) and low (L) rats selectively bred for contrasting anxiety responses in the open-field test, and two inbred strains, spontaneously hypertensive rats (SHR) and Lewis rats whic
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-10
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9. Myocardial contractility of the isovolumetrically beating isolated rat heart
Several indexes of myocardial contractility have been proposed to assess ventricular function in the isovolumetrically beating isolated heart. However, the conclusions reached on the basis of these indexes may be influenced by ventricular geometry rather than contractility itself. The objective of the present study was to assess the performance of widely use
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-10
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10. Imidazoline receptors in the heart: a novel target and a novel mechanism of action that involves atrial natriuretic peptides
Chronic stimulation of sympathetic nervous activity contributes to the development and maintenance of hypertension, leading to left ventricular hypertrophy (LVH), arrhythmias and cardiac death. Moxonidine, an imidazoline antihypertensive compound that preferentially activates imidazoline receptors in brainstem rostroventrolateral medulla, suppresses sympathe
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-08
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11. Food restriction induces in vivo ventricular dysfunction in spontaneously hypertensive rats without impairment of in vitro myocardial contractility
Cardiac structures, function, and myocardial contractility are affected by food restriction (FR). There are few experiments associating undernutrition with hypertension. The aim of the present study was to analyze the effects of FR on the cardiac response to hypertension in a genetic model of hypertension, the spontaneously hypertensive rat (SHR). Five-month
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-04
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12. Atividades e expressão de peptidases em ratos tratados cronicamente com L-NAME, um inibidor da biossintese de oxido nitrico, e em ratos espontaneamente hipertensos
Peptidases play an important role in modulating the activity of endogenous peptides in normal and pathological situations. In this work, we investigated the activity and expression of four peptidases (aminopeptidase M - APM, dipeptidyl peptidase IV - DPP IV, metalloendopeptidase 24.15 - MEP 24.15 and neutral endopeptidase 24.11 - NEP 24.11) in rat tissues (a
Publicado em: 2004