Steroidogenesis
Mostrando 1-12 de 152 artigos, teses e dissertações.
-
1. Classic and current concepts in adrenal steroidogenesis: a reappraisal
ABSTRACT Adrenal steroid biosynthesis and its related pathology are constant evolving disciplines. In this paper, we review classic and current concepts of adrenal steroidogenesis, plus control mechanisms of steroid pathways, distribution of unique enzymes and cofactors, and major steroid families. We highlight the presence of a “mineralocorticoid (MC) pat
Archives of Endocrinology and Metabolism. Publicado em: 2022
-
2. ARMC5 mutations are associated with high levels of proliferating cell nuclear antigen and the presence of the serotonin receptor 5HT4R in PMAH nodules
ABSTRACT Objective To analyze the morphological and functional characteristics of primary macronodular adrenal hyperplasia (PMAH) nodules carrying or not carrying ARMC5 mutations and the consequences of the presence of mutations in terms of the pattern of macronodule composition and functional state. Subjects and methods The analyses were performed by he
Arch. Endocrinol. Metab.. Publicado em: 2020-08
-
3. Effect of recombinant bovine somatotropin (rbST) treatment on follicular population and development in non-lactating dairy cows
Abstract The aim of this study was to evaluate the long-term effects of recombinant bovine somatotropin (rbST) on follicle population and ovulatory follicle development in non-lactating dairy cows. Twenty-one Jersey cows were allocated in rbST (n=11) or control (n=10) groups. On day -60, cows in rbST group received 500 mg of somatotropin (s.c. Lactotropin®,
Anim. Reprod.. Publicado em: 25/11/2019
-
4. New evidences on the regulation of SF-1 expression by POD1/TCF21 in adrenocortical tumor cells
OBJECTIVES: Transcription Factor 21 represses steroidogenic factor 1, a nuclear receptor required for gonadal development, sex determination and the regulation of adrenogonadal steroidogenesis. The aim of this study was to investigate whether silencing or overexpression of the gene Transcription Factor 21 could modulate the gene and protein expression of st
Clinics. Publicado em: 2017-06
-
5. Simultaneous Administration of Dexamethasone and Vitamin E Reversed Experimental Varicocele-induced Impact in testicular tissue in Rats; Correlation with Hsp70-2 Chaperone Expression
ABSTRACTPurpose:This study aimed to investigate the protective effects of isolated and co-administration of vitamin E (VitE) and dexamethasone (DEX) on varicocele (VCL)-induced damages in testicular tissue.Materials and Methods:Wistar rats were divided into five groups (n=6), including; control-sham, non-treated VCL-induced, VitE-treated VCL-induced (VitE, 1
Int. braz j urol.. Publicado em: 2015-08
-
6. Steroidogenesis-related gene expression in the rat ovary exposed to melatonin supplementation
OBJECTIVE: To analyze steroidogenesis-related gene expression in the rat ovary exposed to melatonin supplementation. METHODS: Thirty-two virgin adult female rats were randomized to two groups as follows: the control group GI received vehicle and the experimental group GII received melatonin supplementation (10 µg/night per animal) for 60 consecutive days.
Clinics. Publicado em: 2015-02
-
7. EFEITO DA ASSOCIAÇÃO DO FATOR DE CRESCIMENTO E DIFERENCIAÇÃO 9 (GDF-9) E DO HORMÔNIO FOLÍCULO ESTIMULANTE (FSH) SOBRE O DESENVOLVIMENTO IN VITRO DE FOLÍCULOS PRÉ-ANTRAIS CAPRINOS EM CULTIVO IN SITU DE LONGA DURAÇÃO / EFFECT OF ASSOCIATION AND GROWTH FACTOR DIFFERENTIATION 9 (GDF-9) and hormone FOLLICLE STIMULATING (FSH) DEVELOPMENT OF IN VITRO PREANTRAL FOLLICLES GOATS IN FARMING IN SITU LONG
The aim of this study was to evaluate the effects of growth differentiation factor 9 (GDF-9) and follicle-stimulating hormone (FSH) on the in vitro survival, growth and steroidogenesis of caprine preantral follicles cultured for 16 days. Ovarian fragments were cultured in αMEM+ in the presence or absence of GDF-9 (200 ng/mL) and/or FSH (50 ng/mL) added
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/07/2012
-
8. EFEITO DA EXPOSIÇÃO PERINATAL AO HERBICIDA GLIFOSATO-ROUNDUP NA DIFERENCIAÇÃO SEXUAL E ENDOCRINOLOGIA REPRODUTIVA / nao
O Glifosato-Roundup é um herbicida amplamente utilizado e considerado um potente desregulador endócrino quando administrado para ratos Wistar na fase pré-púbere. Este trabalho teve como objetivo avaliar os efeitos causados por este herbicida na prole de fêmeas tratadas durante o período perinatal. Foram utilizados como modelos experimentais 38 ratos Wi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/09/2011
-
9. THE ROLE OF ANGIOTENSIN II ON FOLLICULAR DOMINANCE OF BOVINE / AÇÃO DA ANGIOTENSINA II NA REGULAÇÃO DA DOMINÂNCIA FOLICULAR EM BOVINOS
Os objetivos do presente trabalho foram determinar a concentração de angiotensina II (AngII) no fluido folicular, caracterizar a expressão dos genes do sistema renina-angiotensina (RAS) nas células foliculares e verificar o papel da AngII na onda folicular, utilizando um modelo in vivo de injeção intrafolicular e in vitro de cultivo de células da gran
Publicado em: 2010
-
10. REGULATION OF INDUCIBLE NITRIC OXIDE SYNTHASE EXPRESSION IN BOVINE GRANULOSA CELLS AND ITS INVOLVEMENT WITH FOLLICULAR DOMINANCE / REGULAÇÃO DA EXPRESSÃO DA ÓXIDO NÍTRICO SINTASE INDUZÍVEL EM CÉLULAS DA GRANULOSA BOVINA E O SEU ENVOLVIMENTO COM A DOMINÂNCIA FOLICULAR
O óxido nítrico (NO) é um importante regulador da atividade ovariana que é produzido a partir da ação de uma família de enzimas denominadas sintases do óxido nítrico (NOS). As isoformas induzível (iNOS) e endotelial (eNOS) estão presentes nos ovários de diversas espécies. Em vacas, embora a produção de NO já tenha sido detectada no fluído fo
Publicado em: 2009
-
11. Analise molecular do loco C4/CYP21 : impacto da variabilidade alelica provocada por recombinações sobre os metodos de avaliação de mutações / Molecular analysis of C4/CYP21 locus : influence of allelic variability caused by recombinations on current methods of mutation detection
Congenital adrenal hyperplasia is caused by deficiency of one of the five enzymes responsible for cortisol synthesis in the steroidogenesis. More than 90% of the cases occur due to deficiency of 21-hidroxilase (21-OH). The haploid human genome bears two copies in tandem of 21-OH coding gene, CYP21A2 and CYP21A1P. Although the two copies are approximately 98%
Publicado em: 2009
-
12. Expression of IGF-II, IGF-IR, SF-1 and DAX-1 genes in pediatric and adult adrenocortical tumors / Expressão dos genes IGF-II, IGF-IR, SF-1 e DAX-1 em tumores adrenocorticais de crianças e adultos
Introduction: The molecular pathogenesis of adrenocortical tumors is heterogeneous and incompletely understood. Insulin-like growth factor II (IGF-II) overexpression has been demonstrated in adult adrenocortical carcinomas. IGF-II exerts its mitogenic effects through interaction with IGF-I receptor (IGF-IR). In addition, steroidogenic factor 1 gene (SF-1) an
Publicado em: 2008