Stress Signaling
Mostrando 1-12 de 818 artigos, teses e dissertações.
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1. RhoA/ROCK-1 Signaling Pathway and Oxidative Stress in Coronary Artery Disease Patients
Abstract Introduction: Coronary artery disease (CAD) is an ischemic condition that occurs as a result of partial or complete interruption of blood flow by narrowing or complete blockage of the vessels supplying the heart, which are called coronary arteries. Our objective in this study is to investigate the RhoA/Rho-associated kinase (ROCK)-1 signaling pathw
Brazilian Journal of Cardiovascular Surgery. Publicado em: 2022
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2. Obesity care: more urgent than ever
ABSTRACT Deleterious effects of free fatty acids, FFAs, on insulin sensitivity are observed in vivo studies in humans. Mechanisms include impaired insulin signaling, oxidative stress, inflammation, and mitochondrial dysfunction, but the effects on insulin secretion are less well known. Our aim was to review the relationship of increased FFAs with insulin res
Arch. Endocrinol. Metab.. Publicado em: 2021-02
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3. Effect of free fatty acids on insulin secretion, insulin sensitivity and incretin effect – a narrative review
ABSTRACT Deleterious effects of free fatty acids, FFAs, on insulin sensitivity are observed in vivo studies in humans. Mechanisms include impaired insulin signaling, oxidative stress, inflammation, and mitochondrial dysfunction, but the effects on insulin secretion are less well known. Our aim was to review the relationship of increased FFAs with insulin res
Arch. Endocrinol. Metab.. Publicado em: 2021-02
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4. Role of FAK signaling in chagasic cardiac hypertrophy
Abstract Cardiac hypertrophy and dysfunction are a significant complication of chronic Chagas disease, with heart failure, stroke, and sudden death related to disease progression. Thus, understanding the signaling pathways involved in the chagasic cardiac hypertrophy may provide potential targets for pharmacological therapy. Herein, we investigated the impli
Braz J Infect Dis. Publicado em: 2020-10
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5. Paralisia facial como complicação neurológica da SARS-CoV-2
Abstract Cardiac hypertrophy and dysfunction are a significant complication of chronic Chagas disease, with heart failure, stroke, and sudden death related to disease progression. Thus, understanding the signaling pathways involved in the chagasic cardiac hypertrophy may provide potential targets for pharmacological therapy. Herein, we investigated the impli
Arq. Neuro-Psiquiatr.. Publicado em: 2020-10
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6. Corticotropin-releasing factor receptor signaling and modulation: implications for stress response and resilience
Abstract Introduction In addition to their role in regulation of the hypothalamic-pituitary-adrenal-axis, corticotropin-releasing factor (CRF) and its related peptides, the urocortins, are important mediators of physiological and pathophysiological processes of the central nervous, cardiovascular, gastrointestinal, immune, endocrine, reproductive, and skin
Trends Psychiatry Psychother.. Publicado em: 2020-06
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7. Effects of growth hormone in the central nervous system
ABSTRACT Growth hormone (GH) is best known for its effect stimulating tissue and somatic growth through the regulation of cell division, regeneration and proliferation. However, GH-responsive neurons are spread over the entire central nervous system, suggesting that they have important roles in the brain. The objective of the present review is to summarize a
Arch. Endocrinol. Metab.. Publicado em: 10/01/2020
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8. From yeast to humans: Understanding the biology of DNA Damage Response (DDR) kinases
Abstract The DNA Damage Response (DDR) is a complex network of biological processes that protect cells from accumulating aberrant DNA structures, thereby maintaining genomic stability and, as a consequence, preventing the development of cancer and other diseases. The DDR pathway is coordinated by a signaling cascade mediated by the PI3K-like kinases (PIKK) A
Genet. Mol. Biol.. Publicado em: 13/12/2019
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9. DNA repair genes in astrocytoma tumorigenesis, progression and therapy resistance
Abstract Glioblastoma (GBM) is the most common and malignant type of primary brain tumor, showing rapid development and resistance to therapies. On average, patients survive 14.6 months after diagnosis and less than 5% survive five years or more. Several pieces of evidence have suggested that the DNA damage signaling and repair activities are directly correl
Genet. Mol. Biol.. Publicado em: 13/12/2019
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10. Sustainable production of bioactive alkaloids in Psychotria L. of southern Brazil: propagation and elicitation strategies
ABSTRACT Psychotria is the largest genus in Rubiaceae. South American species of the genus are promising sources of natural products, mostly due to bioactive monoterpene indole alkaloids they accumulate. These alkaloids can have analgesic, antimutagenic, and antioxidant activities in different experimental models, among other pharmacological properties of in
Acta Bot. Bras.. Publicado em: 07/10/2019
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11. Potential of hydrogen (pH) differentially modulates cadmium stress response in abscisic acid-deficient sitiens tomato mutant
ABSTRACT Uptake of nutrients and cadmium (Cd) are dependent upon many factors, including plant species, ions concentration and pH. Tolerance to Cd-induced oxidative stress can be modulated by phytohormones such as abscisic acid (ABA), which induce the production of reactive oxygen species, activating proteins and enzymes involved in stress response and possi
Bragantia. Publicado em: 05/08/2019
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12. Inhibitory effect of Astragalus polysaccharide on osteoporosis in ovariectomized rats by regulating FoxO3a /Wnt signaling pathway
Abstract Purpose: To investigate inhibitory effect of Astragalus polysaccharide (APS) on osteoporosis in ovariectomized rats by regulating FoxO3a/Wnt2 signaling pathway. Methods: Postmenopausal osteoporosis (PMOP) animal model was developed by excising the bilateral ovaries of rats. The model rats were administered with APS (200 mg/kg, 400 mg/kg, 800 mg/
Acta Cir. Bras.. Publicado em: 03/06/2019