Structure Activity Relationships Biochemistry
Mostrando 1-6 de 6 artigos, teses e dissertações.
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1. Structure-activity study of combretastin and derivatives / Estudo estrutura-atividade da combretastina e derivados
Combretastatin, a stilbene isolated in 80 s, has been widely studied by the pharmaceutical industry due to its promising anticarcinogenic action. As an antineoplastic agent it acts interrupting the polymerization-depolymerization cycle of the microtubules, an important cellular component to motility, strutuctural maintenance and cellular mitosis. Its main fe
Publicado em: 2007
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2. Sínteses química e enzimática de peptídeos: princípios básicos e aplicações
This review begins with a brief discussion of the biological importance and chemical features of peptides. A description of the existing synthetic methods follows with emphasis on the basic aspects of the chemical and enzymatic syntheses. Techniques used to purify and characterize the synthesized peptides are also discussed. Finally, a few applications of th
Química Nova. Publicado em: 2004-10
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3. Study of structure-activity in polycyclic aromatic hidrocarbons / Estudo da atividade carcinogenica dos hidrocarbonetos policiclicos aromaticos atraves de descritores quanticos
Neste trabalho apresentamos estudos de estrutura-atividade realizados para 81 hidrocarbonetos policíclicos aromáticos (PAHs) tentando identificar compostos carcinogênicos. Em particular, empregamos uma nova metodologia desenvolvida para tratar o problema da correlação estrutura geométrica com atividade biológica, denominada Metodologia de Índices Ele
Publicado em: 2003
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4. Enhancement of the cleavage rates of DNA-armed hammerhead ribozymes by various divalent metal ions.
In order to characterize structure-function relationships, the kinetic behavior of chimeric RNA/DNA ribozyme was compared with that of all RNA ribozyme. Determined kcat values were proven to represent the chemical-cleavage step and not the product-dissociation step. In agreement with the finding by Dahm and Uhlenbeck [Biochemistry 30, 9464-9469 (1991)], vari
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5. Design and synthesis of a CD4 beta-turn mimetic that inhibits human immunodeficiency virus envelope glycoprotein gp120 binding and infection of human lymphocytes.
Poor bioavailability, rapid degradation, antigenicity, and high cost often limit the use of proteinaceous pharmaceuticals. One goal of structural biochemistry is the reduction of complex molecules to small functional units that are amenable to high-resolution structural analysis and rapid modification. The dissection of complex proteins into small synthetic
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6. Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase)
A mammalian cytosolic FAD-dependent enzyme that catalyzes the reduction of quinones by N-ribosyl- and N-alkyldihydronicotinamides, but not by NADH, NADPH, or NMNH (reduced nicotinamide mononucleotide), was isolated from bovine kidney more than 30 years ago [S. Liao, J. T. Dulaney and H. G. Williams-Ashman (1962) J. Biol. Chem. 237, 2981–2987]. This enzyme
The National Academy of Sciences of the USA.