Supersensitivity
Mostrando 1-12 de 89 artigos, teses e dissertações.
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1. EFEITOS DOS NEUROLÉPTICOS ATÍPICOS ZIPRASIDONA E AMISULPRIDA EM MODELOS ANIMAIS DE DISCINESIA TARDIA.
Tardive dyskinesia - the main side effect of long-term treatment with typical neuroleptics - has been related to nigrostriatal dopaminergic supersensitivity. Treatment with atypical neuroleptics is associated with a decreased risk for development of tardive dyskinesia. The aim of the present study was to verify the effects of several doses the atypical neuro
Publicado em: 2009
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2. Gentle handling temporarily increases c-Fos in the substantia nigra pars compacta
Dopaminergic neurotransmission is involved in the regulation of sleep. In particular, the nigrostriatal pathway is an important center of sleep regulation. We hypothesized that dopaminergic neurons located in substantia nigra pars compacta (SNpc) could be activated by gentle handling, a method to obtain sleep deprivation (SD). Adult male C57/BL6J mice (N = 5
Brazilian Journal of Medical and Biological Research. Publicado em: 30/09/2008
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3. Atherogenic effects of chronic stress on thoracic aorta rats / Efeitos aterogenicos do estresse cronico em aorta toracica de ratos
Metabolic and vascular complications can result in atherosclerosis, which constitutes a great problem of public health, associated to approximately half of the deaths related to the cardiovascular illnesses in the occidental world. Therefore to the establishment of guidelines for treatment and prevention of cardiovascular diseases, it is important to study r
Publicado em: 2008
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4. O papel do sistema dopaminérgico nigroestriatal na neurobiologia do sono / The role of the dopaminergic nigrostriatal system in the sleep neurobiology.
Dopamine (DA) is critically involved in regulating neural processes responsible for complex movements and emotions. Alterations in central dopaminergic neurotransmission have been implicated in important neurological and psychiatric disorders such as Parkinsons disease (PD) and schizophrenia. In addition, DA has recently been recognized as instrumental in th
Publicado em: 2008
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5. Resposta inotropica a catecolaminas em miocitos ventriculares isolados de ratos submetidos a choque nas patas / Inotropic esponsiveness to catecholamines in ventricular myocytes isolated from footshock-stressed rats
Supersensitivity to isoproterenol (ISO) chronotropic effect has been described in right atria from footshock-stressed rats, but information on inotropic responsiveness, particularly of the ventricles, is scarce. The goal of this study was to analyze the inotropic and pro-arrhythmic effect of catecholamines on left ventricular myocytes from footshockstressed
Publicado em: 2007
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6. Efeito da interrupÃÃo abrupta do tratamento crÃnico com brometo de ipratrÃpio na resposta contrÃtil de traquÃias isoladas de ratos / Effect of ipratropium bromide abrupt withdrawal, after chronic treatment, in contractile response of isolated rat tracheas
Visando estudar os efeitos da retirada abrupta apÃs o tratamento crÃnico com brometo de ipratrÃpio (BI) ratos machos pesando 200-250 g no inÃcio dos experimentos, foram introduzidos em uma caixa de acrÃlico e submetidos durante 7 minutos à inalaÃÃo de brometo de ipratrÃpio (600ÂM). Este procedimento se repetiu a cada quatro horas durante um perÃod
Publicado em: 2004
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7. Sawtooth waves during REM sleep after administration of haloperidol combined with total sleep deprivation in healthy young subjects
We sought to examine the possible participation of dopaminergic receptors in the phasic events that occur during rapid eye movement (REM) sleep, known as sawtooth waves (STW). These phasic phenomena of REM sleep exhibit a unique morphology and, although they represent a characteristic feature of REM sleep, little is known about the mechanisms which generate
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-05
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8. Acute buspirone abolishes the expression of behavioral dopaminergic supersensitivity in mice
Previous studies have shown that rats withdrawn from long-term treatment with dopamine receptor blockers exhibit dopaminergic supersensitivity, which can be behaviorally evaluated by enhanced general activity observed in an open-field. Recently, it has been reported that co-treatment with the non-benzodiazepine anxiolytic buspirone attenuates the development
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-02
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9. Influencia do ciclo estral sobre as alterações de sensibilidade adrenergica induzidas por estresse agudo
Stress may change the sensitivity to catecholamines of many tissues. The aim of this study was to evaluate the sensitivity to noradrenaline and adrenaline of the right atria from female rats submitted to acute stress during the different phases of the estrous cycle.Wistar female rats at proestrus, estrus, metestrus and diestrus were submitted to one 50 min-s
Publicado em: 2002
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10. Receptores de glicocorticoides e subtipos de adrenoceptores beta em atrio direito de ratos submetidos a estresse
Right atria of male or female rats sacrificed at diestrus and submitted to foot shock stress show supersensitivity to non-selective and selective Bz-adrenoceptor agonists. This supersensitivity was due to increased Bz-adrenoceptor protein level expression. This tissue also showed subsensitivity to non selective Bl-adrenoceptor agonist, but no changes in BI a
Publicado em: 2002
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11. Sensibilidade a agonistas [beta]-adrenergicos em atrio esquerdo isolado de ratos submetidos a estresse
Following foot shock stress white adipocytes and right atria from male and right atria from female rats sacrificed at diestrous, are supersensitive to the chronotropic effect of isoprenaline. Right atria from female rats are also subsensitive to noradrenaline. In the present study, we investigated whether the inotropic response to B-adrenergic agonists was a
Publicado em: 2002
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12. Estresse e sensibilidade as catecolaminas em atrio de cobaia
Considering that isolated tissues of stressed rats show alterations on sensitivity to catecholamines, the objectives of this work was to verify whether isolated tissues from guinea-pigs submitted to the same experimental protocols also show similar alterations. Our results show that the swimming or footshock stress induce sensitivity alterations of the chron
Publicado em: 2001